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All Topic Review Biography
Topic Review
Natural Product Treat Lung Diseases
As a traditional source for modern pharmaceutical discovery and potential drug leads, natural products have played an integral role in treating patients due to their unique structural, chemical, and biological diversity. A wide range of natural products can be considered promising anti-COVID-19 or anti-lung cancer agents have gained widespread attention, including natural products as monotherapy for the treatment of SARS-CoV-2 (ginkgolic acid, shiraiachrome A, resveratrol, and baicalein) or lung cancer (daurisoline, graveospene A, deguelin, and erianin) or in combination with FDA-approved anti-SARS-CoV-2 agents (cepharanthine plus nelfinavir, linoleic acid plus remdesivir) and anti-lung cancer agents (curcumin and cisplatin, celastrol and gefitinib).
  • 445
  • 28 Jun 2021
Topic Review
Phytochemistry, Medicinal Uses and Pharmacological Activities of Parkia
Parkia is a genus of flowering plants belonging to the family Fabaceae (subfamily, Mimosoideae) with pan-tropical distribution. The word Parkia was named after the Scottish explorer Mungo Park, who drowned in the Niger River, Nigeria in January 1805. The genus Parkia (Fabaceae, Subfamily, Mimosoideae) comprises about 34 species of mostly evergreen trees widely distributed across neotropics, Asia, and Africa. 
  • 445
  • 10 Feb 2023
Topic Review
Multi-Drug-Resistant Bacterial Infections
Antimicrobial resistance (AMR) remains one of the top public health issues of global concern. Among the most important strategies for AMR control there is the correct and appropriate use of antibiotics, including those available for the treatment of AMR pathogens.
  • 444
  • 15 Jun 2021
Topic Review
Biomarkers Derived from the Molecular Profiling of TNBC
Triple-negative breast cancer (TNBC), the most aggressive and heterogenous type of cancer, lacks the expression of hormones like estrogen, progesterone, and human epidermal growth receptor-2, making chemotherapy the only treatment regimen against TNBC. To overcome the problem faced during chemotherapy, and to address the heterogeneity of TNBC, targeted therapy emerged based on the molecular profiling of TNBC. Several biomarkers are used as targets for the precision therapy in TNBC, including EGFR, VGFR, TP53, interleukins, insulin-like growth factor binding proteins, c-MET, androgen receptor, BRCA1, glucocorticoid, PTEN, ALDH1, etc.
  • 444
  • 16 Aug 2023
Topic Review
Antioxidant Activities of Natural Polysaccharides and their Derivatives
Natural polysaccharides are a type of natural biomacromolecule found in plants, fungi, algae, animals, and bacteria. Due to their nontoxic, stable, biodegradable, biocompatibility, and excellent antioxidant activity, natural polysaccharides contribute to the potential value in treating or preventing disease caused by oxidative stress. Polysaccharides can reduce the damage to the cell structure, regulate the signal pathways related to antioxidation, improve the intracellular antioxidant enzyme system, reduce the substances that easily produce reactive oxygen species (ROS), and protect the body tissue from ROS-induced damage through free radical scavenging activity and immunomodulatory activity. Natural polysaccharides play an irreplaceable therapeutic role and have received more and more attention. Publications related to natural polysaccharides are also increasing.
  • 443
  • 27 Dec 2022
Topic Review
Bisphenol A and Obesity
Lines of evidence have shown the embryogenic and transgenerational impact of bisphenol A (BPA), an endocrine-disrupting chemical, on immune-metabolic alterations, inflammation, and oxidative stress, while BPA toxic effects in adult obese mice are still overlooked. Here, we evaluate BPA’s worsening effect on several hepatic maladaptive processes associated to high-fat diet (HFD)-induced obesity in mice. After 12 weeks HFD feeding, C57Bl/6J male mice were exposed daily to BPA (50 μg/kg per os) along with HFD for 3 weeks. Glucose tolerance and lipid metabolism were examined in serum and/or liver. Hepatic oxidative damage (reactive oxygen species, malondialdehyde, antioxidant enzymes), and mitochondrial respiratory capacity were evaluated. Moreover, liver damage progression and inflammatory/immune response were determined by histological and molecular analysis. BPA amplified HFD-induced alteration of key factors involved in glucose and lipid metabolism, liver triglycerides accumulation, and worsened mitochondrial dysfunction by increasing oxidative stress and reducing antioxidant defense. The exacerbation by BPA of hepatic immune-metabolic dysfunction induced by HFD was shown by increased toll-like receptor-4 and its downstream pathways (i.e., NF-kB and NLRP3 inflammasome) amplifying inflammatory cytokine transcription and promoting fibrosis progression.
  • 441
  • 17 Dec 2020
Topic Review
Soy Isoflavones
After consumption of soy isoflavones, a study revealed statistically insignificant reduction in fasting glucose, insulin, HbA1c, and HOMA-IR (changes in glucose metabolism). The observed ability of both extracted isoflavone and soy protein with isoflavones to modulate the lipid profile suggests benefits in preventing cardiovascular events in diabetic subjects.
  • 439
  • 21 Jun 2021
Topic Review
COVID-19, Respiratory Diseases & Drug-Drug Interactions
The absence of COVID-19-targeted treatments has led scientist to exploit available scientific evidence for potential efficient drugs that may block biological pathways of SARS-CoV-2 and several molecules have been emerged as promising pharmacological agents. Then again, due to the criticality of the disease, it is important for healthcare providers in COVID-19 clinics to recognize potential drug-drug interactions (DDIs) that may lead to adverse drug reactions (ADRs) and additional burdens in patients' health status from the administration of these agents.
  • 439
  • 17 Dec 2021
Topic Review
Pharmacological Effects and Clinical Prospects of Cepharanthine
Cepharanthine is an active ingredient separated and extracted from Stephania cepharantha Hayata, a Menispermaceae plant. As a bisbenzylisoquinoline alkaloid, cepharanthine has various pharmacological properties, including antioxidant, anti-inflammatory, immunomodulatory, antitumoral, and antiviral effects. Following the emergence of coronavirus disease 2019 (COVID-19), cepharanthine has been found to have excellent anti-COVID-19 activity.
  • 439
  • 23 Dec 2022
Topic Review
Novel Psychoactive Substances
Novel psychoactive substances (NPS) represent a severe health risk for drug users. The molecular mechanisms underlying the action of NPS are more complex than expected, with a wide range of overlap among activated receptors and neurotransmitter systems.
  • 437
  • 21 May 2021
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