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Topic Review
Kidney Tubular Damage Secondary to Deferasirox
Deferasirox is a first-line therapy for iron overload that can sometimes cause kidney damage. A proximal tubulopathy pattern may be observed on treatment with deferasirox. Since deferasirox-associated kidney damage is dose-dependent, physicians should prescribe the lowest efficacious dose. 
  • 389
  • 12 Jan 2022
Topic Review
Magnetic nanoparticles: coating and applications
Magnetic nanoparticles (MNPs) have great potential in material science, drug delivery, magnetic resonance imaging, and therapeutic applications. Indeed, a number of iron oxide nanoparticles have been withdrawn due to their poor clinical performance and/or toxicity issues. MNPs have successfully been converted into water-soluble, stable, bio-accessible systems using the proprietary various coating strategy. Herein, we summarize the data of applications and coating strategies of MNPs.
  • 858
  • 11 Jan 2022
Topic Review
Classes of Translational Readthrough-Inducing Drugs
Translational Readthrough-Inducing Drugs (TRIDs) can affect various biomolecular targets, leading to different types of readthrough.
  • 559
  • 11 Jan 2022
Topic Review
Mangiferin
Mangiferin is a naturally occurring C-glucosylxantone that has substantial potential for the treatment of various diseases. It possesses antioxidant, anti-infection, anti-cancer, anti-diabetic, cardiovascular, neuroprotective properties and it also increases immunity.
  • 1.7K
  • 10 Jan 2022
Topic Review
Anti-inflammatory Effect of Essential Oil from Z. striolatum
Zingiber striolatum Diels (Z. striolatum), a widely popular vegetable in China, is famous for its medicinal and nutritional values. However, the anti-inflammatory effects of essential oil from Z. striolatum (EOZS) remain unclear. This research unveils the antioxidant capability and potential molecular mechanism of EOZS in regulating inflammatory response, and suggests the application of EOZS as a natural antioxidant and anti-inflammatory agent in the pharmaceutical and functional food industries. 
  • 520
  • 06 Jan 2022
Topic Review
MRNA Therapies
Currently, mRNA appears as a very promising and innovative therapeutic approach for diseases associated with functional loss of proteins, through the administration of a synthetic mRNA, which promotes the reestablishment of protein levels and restores its function. Moreover, mRNA can create new cellular functions, for example for passive immunization, allowing to stimulate the immune system, through the translation of antigenic mRNA for specific cell recognition (e.g., cancer cells) or antibody production. The fact that a relatively small amount of encoded antigen, from a synthetic mRNA, can be sufficient to obtain robust signs of efficacy, is one of the main advantages of using this biomolecule in immunotherapy. However, the global success of such mRNA-based treatments depends on a high number of these biomolecules and an effective in vivo delivery to target cells involved in a given disease. After proving that in vivo mRNA administration is possible and viable, the concept of using mRNA as a therapeutic basis was readily accepted and used in a variety of diseases, including diabetes, HIV infection, anemia, hemophilia, myocardial infarction, cancer, asthma, metabolic disorders, fibrosis, skeletal degeneration and neurological disorders, such as Friedreich’s ataxia and Alzheimer’s disease.
  • 494
  • 04 Jan 2022
Topic Review
Glucosamine and Chondroitin for Osteoarthritis
Glucosamine is a water-soluble amino monosaccharide available in two forms (glucosamine sulphate and glucosamine hydrochloride), which is a normal constituent of glycosaminoglycans (GAGs) in cartilage matrix and in the synovial fluid and consequently present in high quantities in articular cartilage. It is a constituent of keratan sulphate. Chondroitin is a major component of the extracellular matrix of articular cartilage, which played an important role in creating considerable osmotic pressure. In this way, it could provide cartilage with resistance and elasticity to resist tensile stresses during loading conditions.
  • 408
  • 31 Dec 2021
Topic Review
Clinical Considerations of Benzodiazepines
Benzodiazepines (BZDs) are among one of the most widely prescribed drug classes in the United States. BZDs are a class of psychoactive drugs known for their depressant effect on the central nervous system (CNS). They quickly diffuse through the blood–brain barrier to affect the inhibitory neurotransmitter GABA and exert sedative effects. One of the debilitating side effects of BZDs is their addictive potential. The dependence on BZDs generally leads to withdrawal symptoms, requiring careful tapering of the medication when prescribed. Regular use of BZDs has been shown to cause severe, harmful psychological and physical dependence, leading to withdrawal symptoms similar to that of alcohol withdrawal.
  • 475
  • 23 Dec 2021
Topic Review
Drug Interaction of Sorafenib and Morphine
A combination of the tyrosine kinase inhibitor—sorafenib—and the opioid analgesic—morphine—can be found in the treatment of cancer patients. Since both are substrates of P-glycoprotein (P-gp), and sorafenib is also an inhibitor of P-gp, their co-administration may affect their pharmacokinetics, and thus the safety and efficacy of cancer therapy. 
  • 396
  • 23 Dec 2021
Topic Review
Bacterial Ghosts-Based Vaccine
Bacterial ghosts (BGs) are empty bacterial envelopes of Gram-negative bacteria produced by controlled expressions of cloned gene E, forming a lysis tunnel structure within the envelope of the living bacteria.
  • 742
  • 22 Dec 2021
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