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Topic Review
Nanocarriers in Enhanced Antifungal Delivery
Fungal infections are an extremely serious health problem, particularly in patients with compromised immune systems. Most antifungal agents have low aqueous solubility, which may hamper their bioavailability. Their complexation with cyclodextrins (CDs) could increase the solubility of antifungals, facilitating their antifungal efficacy. Nanoparticulate systems are promising carriers for antifungal delivery due to their ability to overcome the drawbacks of conventional dosage forms. CD-based nanocarriers could form beneficial combinations of CDs and nanoparticulate platforms. These systems have synergistic or additive effects regarding improved drug loading, enhanced chemical stability, and enhanced drug permeation through membranes, thereby increasing the bioavailability of drugs. 
  • 666
  • 08 Dec 2022
Topic Review
Nano-Gels in Skin Cancer
Nano-gels, a dual combination of hydrogels and nanoparticles, have demonstrated significant promise as a targeted drug delivery system in the treatment of cancer, attributing to excellent drug loading capacity. Skin disorders, the 4th foremost source of non-fatal diseases, are frequently the outward manifestation of more serious systemic illnesses, such as HIV, and neglected tropical diseases, such as elephantiasis and other ailments causing lymphedema.
  • 471
  • 27 Apr 2023
Topic Review
Nano-Formulations for Pulmonary Delivery
With the development of nanotechnology and confronting the problems of traditional pharmaceutical formulations in treating lung diseases, inhalable nano-formulations have attracted interest. Inhalable nano-formulations for treating lung diseases allow for precise pulmonary drug delivery, overcoming physiological barriers, improving aerosol lung deposition rates, and increasing drug bioavailability. They are expected to solve the difficulties faced in treating lung diseases. 
  • 125
  • 07 Feb 2024
Topic Review
Nano-Drug Delivery Systems Targeting Colorectal Cancer
Colorectal cancer (CRC) is a usual digestive tract malignancy and the third main cause of cancer death around the world, with a high occurrence rate and mortality rate. Conventional therapies for CRC have certain side effects and restrictions. However, the exciting thing is that with the rapid development of nanotechnology, nanoparticles have gradually become more valuable drug delivery systems than traditional therapies because of their capacity to control drug release and target CRC. This also promotes the application of nano-drug targeted delivery systems in the therapy of CRC.
  • 808
  • 24 May 2022
Topic Review
Nano and Microemulsions for Depression and Anxiety Treatment
Most drugs used for the treatment of depression, anxiety and related disorders have low absorption, high metabolism, low brain targeting and/or low water solubility, which can make it hard to formulate them at high strength and can also lead to decreased bioavailability. Incorporating these drugs into nanometric emulsions can solve these issues. Nanometric emulsions were able to increase drug strength up to 20,270-fold (compared to aqueous solubility). The formulations showed droplet size, polydispersity index, zeta potential, viscosity, osmolality, pH, in vitro drug release and ex vivo drug permeation as adequate for the intended effect and administration route.
  • 556
  • 23 Dec 2022
Topic Review
NaDES Application in Cosmetic and Pharmaceutical Fields
Natural deep eutectic solvents (NaDES) represent a new generation of green, non-flammable solvents, useful as an efficient alternative to the well-known ionic liquids. They can be easily prepared and exhibit unexpected solubilizing power for lipophilic molecules, although those of a hydrophilic nature are mostly used. For their unique properties, they can be recommend for different cosmetic and pharmaceutical applications, ranging from sustainable extraction, obtaining ready-to-use ingredients, to the development of biocompatible drug delivery responsive systems. 
  • 141
  • 01 Feb 2024
Topic Review
Myeloid Differentiation 88 (MyD88)
Myeloid differentiation 88 (MyD88) is a well-established inflammatory adaptor protein.
  • 258
  • 05 May 2021
Topic Review
Mycotoxins
Mycotoxins are secondary metabolites produced by fungal species that commonly have a toxic effect on human and animal health. Different foodstuff can be contaminated and are considered the major source of human exposure to mycotoxins, but occupational and environmental exposure can also significantly contribute to this problem.
  • 781
  • 19 Feb 2021
Topic Review
MUTYH Gene
The MUTYH gene is located on the short arm of chromosome 1 (1p34.1) and encodes instructions for the MYH glycosylase enzyme.
  • 629
  • 02 Feb 2021
Topic Review
Mushrooms as Therapeutic Adjuvant of Cancer Therapies
Mushrooms may act as a potentiator of host defense mechanisms and decrease adverse events in patients with cancer undergoing conventional therapies. 
  • 345
  • 21 Feb 2022
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