Topic Review
Ethnomedicinal Properties and Pharmacological Uses of Moringa oleifera
Moringa oleifera (M. oleifera), the “miracle tree”, thrives globally in almost all tropical and subtropical regions, but it is believed to be native to Afghanistan, Bangladesh, India, and Pakistan. The Moringa family comprises 13 species (M. oleifera, M. arborea, M. rivae, M. ruspoliana, M. drouhardii, M. hildebrandtii, M. concanensis, M. borziana, M. longituba, M. pygmaea, M. ovalifolia, M. peregrina, M. stenopetala), of which M. oleifera has become well known for its use in nutrition, biogas production, fertilizer, etc. Moringa has the unique property of tolerating drought. Studies have shown that M. oleifera is among the cheapest and most reliable alternatives for good nutrition. Nearly all parts of the tree are used for their essential nutrients. M. oleifera leaves have a high content of beta-carotene, minerals, calcium, and potassium. Dried leaves have an oleic acid content of about 70%, which makes them suitable for making moisturizers. The powdered leaves are used to make many beverages, of which “Zija” is the most popular in India. The bark of the tree is considered very useful in the treatment of different disorders such as ulcers, toothache, and hypertension. Roots, however, are found to have a role in the treatment of toothache, helminthiasis, and paralysis. The flowers are used to treat ulcers, enlarged spleen, and to produce aphrodisiac substances. The tree is believed to have incredible properties in treating malnutrition in infants and lactating mothers. 
  • 802
  • 13 Feb 2023
Topic Review
Artemisia absinthium L.
Artemisia absinthium – wormwood (Asteraceae) – is a very important species in the history of medicine, formerly described in medieval Europe as “the most important master against all exhaustions”. It is a species known as a medicinal plant in Europe and also in West Asia and North America. The raw material obtained from this species is Artemisiae herba and Artemisiae absinthium aetheroleum. The main substances responsible for the biological activity of the herb are: the essential oil, bitter sesquiterpenoid lactones, flavonoids, another bitterness-imparting compounds, azulenes, phenolic acids, tannins and lignans. In the official European medicine, the species is used in both allopathy and homeopathy. In the traditional Asian and European medicine, it has been used as an effective agent in gastrointestinal ailments and also in the treatment of helminthiasis, anaemia, insomnia, bladder diseases, difficult-to-heal wounds, and fever. Today, numerous other directions of biological activity of the components of this species have been demonstrated and confirmed by scientific research, antiprotozoal, antibacterial, antifungal, anti-ulcer, hepatoprotective, anti-inflammatory, immunostimulatory, cytotoxic, analgesic, neuroprotective, antidepressant, procognitive, neurotrophic, and cell membrane stabilizing activities. A. absinthium is also making a successful career as a cosmetic plant. In addition, the importance of this species as a spice plant and valuable additive in the alcohol industry (famous absinthe and vermouth-type wines) has not decreased. The species has also become an object of biotechnological research.
  • 802
  • 27 Jan 2022
Topic Review
The Genus Porophyllum
The genus Porophyllum (family Asteraceae) is native to the western hemisphere, growing in tropical and subtropical North and South America. Mexico is an important center of diversification of the genus. Plants belong of genus Porophyllum have been used in Mexican traditional medicine to treat kidney and intestinal diseases, parasitic, bacterial, and fungal infections and anti-inflammatory and anti-nociceptive activities.
  • 803
  • 28 Sep 2021
Topic Review
Beta-Blockers and Cancer
Cancer is one of the leading causes of death worldwide. After diagnosis, cancer treatment may involve radiotherapy, chemotherapy, and surgery. Several of the approaches used to treat cancer also attack normal cells and, thus, there is the need for more effective treatments that decrease the toxicity to normal cells and increase the success rates of treatment. The use of beta-blockers in cancer has been studied for their antagonist action on the adrenergic system through inhibition of beta-adrenergic receptors. Besides regulating processes such as blood pressure, heart rate, and airway strength or reactivity, beta-blockers block mechanisms that trigger tumorigenesis, angiogenesis, and tumor metastasis.
  • 800
  • 28 May 2021
Topic Review
New Discovered Molecules of COVID-19
New molecules/drugs are discovered by humans for the therapeutic management of new diseases or to address existing health challenges. New molecules/drugs require extensive clinical investigations, followed by approval from drug regulatory agencies for marketing.
  • 801
  • 13 Feb 2023
Topic Review
Thymoquinone in Cancers Therapy
To date, natural products are widely used as pharmaceutical agents for many human diseases and cancers. One of the most popular natural products that have been studied for anticancer properties is thymoquinone (TQ). As a bioactive compound of Nigella sativa, TQ has shown anticancer activities through the inhibition of cell proliferation, migration, and invasion. The anticancer efficacy of TQ is being investigated in several human cancers such as pancreatic cancer, breast cancer, colon cancer, hepatic cancer, cervical cancer, and leukemia.
  • 799
  • 07 May 2021
Topic Review
Environmental DNA/RNA and Exposomics
Records of eDNA/eRNA exposome may reflect the early appearance, persistence, and presence of biotic and/or abiotic-exposure-mediated modifications in these nucleic acid molecules. Functional genome- and epigenome-wide mapping of eDNA offer great promise to help elucidate the human exposome. Assessment of longitudinal exposure to physical, biological, and chemical agents present in the environment through eDNA/eRNA may enable the building of an integrative causal dynamic stochastic model to estimate environmental causes of human health deficits. Development and validation of monitoring of eDNA/eRNA exposome should seriously be considered to introduce into safety and risk assessment and as surrogates of chronic exposure to environmental stressors.
  • 798
  • 17 Jul 2020
Topic Review
Microbial Biosurfactants
Surface-active molecules also known as surfactants are chemicals that have key impacts on several aspects of our daily products and life. Most of these chemical surfactants originate from petrochemical of oleochemical sources and are ingredients of household laundry cleaning agents, cosmetics, pharmaceutical, environmental cleaning products, petroleum, and agro-food processing industry. Worldwide use of these compounds has been steadily increasing during the past few decades and will be further increasing in the future.  Most such chemical surfactants  however, have negative effects on the environment, a fact that led to the search for alternatives with less impact and the shift towards a more sustainable environmental friendly biological surfactants (biosurfactants) which was mainly driven by the sustainability agenda by many international players in the field. Most these biosurfactants are produced by microorganisms (bacteria and fungi) and the advantages they bring include much lower toxicity, relative stability at high temperature and in adverse environments in addition to being readily biodegradable when, discharged into the environment. Many chemical surfactants included in cosmetic and pharmaceutical compounds have been reported to have the potential to cause detrimental effects such as allergic reactions and skin irritations to the human skin which encouraged the search for a more suitable replacements  with less or no negative effects on skin health. As biosurfactants were known to exhibit skin compatibility, protection and surface moisturizing effects which are key components for an effective skincare routine in addition to lower toxicity. Interest therefore in biosurfactants that have antimicrobial, skin surface moisturizing and low toxicity properties which would make them suitable substitutes for chemical surfactants in current cosmetic and personal skincare and pharmaceutical formulations has been steadily increasing. 
  • 800
  • 24 Mar 2023
Topic Review
Spatiotemporal Release of Anticancer Drugs
To overcome cancer, various chemotherapeutic studies are in progress; among these, studies on nano-formulated combinatorial drugs (NFCDs) are being actively pursued. NFCDs function via a fusion technology that includes a drug delivery system using nanoparticles as a carrier and a combinatorial drug therapy using two or more drugs. It not only includes the advantages of these two technologies, such as ensuring stability of drugs, selectively transporting drugs to cancer cells, and synergistic effects of two or more drugs, but also has the additional benefit of enabling the spatiotemporal and controlled release of drugs. This spatial and temporal drug release from NFCDs depends on the application of nanotechnology and the composition of the combination drug. 
  • 796
  • 05 Apr 2021
Topic Review
The Renin-Angiotensin-Aldosterone System
The renin-angiotensin-aldosterone system (RAAS) is comprised of two main branches, with ACE2 representing a crucial component of the protective part of the complex. The ACE2/Ang (1-7) axis is well represented in the testis, heart, brain, kidney, and intestine. Infection with the novel SARS-CoV-2 virus determines downregulation of ACE2 and interrupts the equilibrium between ACE and ACE2 in these organs.
  • 795
  • 30 Sep 2022
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