Submitted Successfully!
To reward your contribution, here is a gift for you: A free trial for our video production service.
Thank you for your contribution! You can also upload a video entry or images related to this topic.
Version Summary Created by Modification Content Size Created at Operation
1 -- 3823 2023-02-12 15:35:23 |
2 format correct Meta information modification 3823 2023-02-13 06:15:30 | |
3 format correct -1 word(s) 3822 2023-02-13 06:17:18 |

Video Upload Options

Do you have a full video?

Confirm

Are you sure to Delete?
Cite
If you have any further questions, please contact Encyclopedia Editorial Office.
Pareek, A.;  Pant, M.;  Gupta, M.M.;  Kashania, P.;  Ratan, Y.;  Jain, V.;  Pareek, A.;  Chuturgoon, A.A. Ethnomedicinal Properties and Pharmacological Uses of Moringa oleifera. Encyclopedia. Available online: https://encyclopedia.pub/entry/41130 (accessed on 21 June 2024).
Pareek A,  Pant M,  Gupta MM,  Kashania P,  Ratan Y,  Jain V, et al. Ethnomedicinal Properties and Pharmacological Uses of Moringa oleifera. Encyclopedia. Available at: https://encyclopedia.pub/entry/41130. Accessed June 21, 2024.
Pareek, Ashutosh, Malvika Pant, Madan Mohan Gupta, Pushpa Kashania, Yashumati Ratan, Vivek Jain, Aaushi Pareek, Anil A. Chuturgoon. "Ethnomedicinal Properties and Pharmacological Uses of Moringa oleifera" Encyclopedia, https://encyclopedia.pub/entry/41130 (accessed June 21, 2024).
Pareek, A.,  Pant, M.,  Gupta, M.M.,  Kashania, P.,  Ratan, Y.,  Jain, V.,  Pareek, A., & Chuturgoon, A.A. (2023, February 12). Ethnomedicinal Properties and Pharmacological Uses of Moringa oleifera. In Encyclopedia. https://encyclopedia.pub/entry/41130
Pareek, Ashutosh, et al. "Ethnomedicinal Properties and Pharmacological Uses of Moringa oleifera." Encyclopedia. Web. 12 February, 2023.
Ethnomedicinal Properties and Pharmacological Uses of Moringa oleifera
Edit

Moringa oleifera (M. oleifera), the “miracle tree”, thrives globally in almost all tropical and subtropical regions, but it is believed to be native to Afghanistan, Bangladesh, India, and Pakistan. The Moringa family comprises 13 species (M. oleifera, M. arborea, M. rivae, M. ruspoliana, M. drouhardii, M. hildebrandtii, M. concanensis, M. borziana, M. longituba, M. pygmaea, M. ovalifolia, M. peregrina, M. stenopetala), of which M. oleifera has become well known for its use in nutrition, biogas production, fertilizer, etc. Moringa has the unique property of tolerating drought. Studies have shown that M. oleifera is among the cheapest and most reliable alternatives for good nutrition. Nearly all parts of the tree are used for their essential nutrients. M. oleifera leaves have a high content of beta-carotene, minerals, calcium, and potassium. Dried leaves have an oleic acid content of about 70%, which makes them suitable for making moisturizers. The powdered leaves are used to make many beverages, of which “Zija” is the most popular in India. The bark of the tree is considered very useful in the treatment of different disorders such as ulcers, toothache, and hypertension. Roots, however, are found to have a role in the treatment of toothache, helminthiasis, and paralysis. The flowers are used to treat ulcers, enlarged spleen, and to produce aphrodisiac substances. The tree is believed to have incredible properties in treating malnutrition in infants and lactating mothers. 

Moringa oleifera compound seeds Ethanomedicinal uses

1. Ethnomedicinal/Traditional Properties

People worldwide have included M. oleifera in their diet since ancient times because of its vital therapeutic values (Table 1). Various medicines made from the plant are said to have ethnomedicinal properties for curing diseases and have been used for centuries. Approximately every part (leaf, pod, bark, gum, flower, seed, seed oil, and root) of this plant has been used to treat one disease or another [1]. Uses of M. oleifera are observed in pathological alterations such as antihypertensive [2], anti-anxiety [3], anti-diarrheal [4], and as a diuretic [5]. Moringa is also used to treat dysentery [6] and colitis [7]. A poultice made from Moringa leaves is a quick remedy for inflammatory conditions such as glandular inflammation, headache, and bronchitis [8]. The pods treat hepatitis and relieve joint pain [9]. The roots are conventionally used to treat kidney stones [10], liver diseases [11], inflammation [12], ulcers [13], and pain associated with the ear and tooth [14]. The bark of the stem is used to treat wounds and skin infections [15]. Indians use the gum extracted from this plant to treat fever, and it is also used to induce abortions [16]. The seeds of the plant act as a laxative and are used in the treatment of tumors, prostate, and bladder problems [17]. The seeds show promise for the treatment of arthritis by altering oxidative stress and reducing inflammation [18]. Preparations from the plant leaves benefit nursing mothers and malnourished infants and improve the general health of the population. The leaves have been useful for patients suffering from insomnia [19] and treating wounds [20]. Moringa is used incredibly extensively in the cosmetic industry nowadays, and in ancient Egyptian history, it was similarly used for preparing dermal ointments [21].

2. Pharmacological Uses

Recent pharmacological studies have revealed that different extracts of M. oleifera exhibit different pharmacological activities, such as antimicrobial [27], antifungal [28], anti-inflammatory [29], antioxidant [30], anticancer [31], fertility [32], wound healing [27], and other pharmacological activities mentioned below (Table 2).
Table 2. Phytoconstituents of Moringa and their relevant therapeutic effects.

2.1. Antimicrobial and Antifungal Activity

M. oleifera ethanolic root extract contains a compound N-benzylethyl thioformate (an aglycone of deoxyniazimincin) responsible for the antimicrobial and antifungal effect toward an extensive array of microbes and fungi [28]. M. oleifera methanolic leaf extract may exert inhibition of urinary tract infections caused by Gram-negative and Gram-positive bacteria such as Klebsiella pneumoniae, Staphylococcus aureus, Escherichia coli, and Staphylococcus saprophyticus [53].
The inhibitory effect of extracts from leaves, seeds, and stems of M. oleifera has been specified in various fungal strains such as Aspergillus flavus, Aspergillus terreus, Aspergillus nidulans, Rhizoctonia solani, Aspergillus niger, Aspergillus oryzae, Fusarium solani, Penicillium sclerotigenum, Cladosporium cladosporioides, Trichophyton mentagrophytes, Penicillium species, Pullarium species [28]. M. oleifera seeds have active components 4-(alpha-L-rhamanosyloxy) benzyl isothiocyanates, which are believed to be responsible for their antimicrobial activity [54]. The juice of Moringa leaves also showed potential against human pathogenic bacteria [27]. The methanolic leaf extract has nearly 99% inhibition against Botrytis cinerea (a necrotrophic plant fungus) [55].
The fruit of M. oleifera contains alkaloids, flavonoids, and steroids, which have an inhibitory effect against the culture of Candida albicans by either denaturing the protein or inhibiting the germination of spores through the steroid ring they contain [56].
Strong inhibitory effects of moringa seed kernel extract were observed for Bacillus cereus, Staphylococcus aureus, Mucor species, and Aspergillus species. However, it was less effective against P. aeruginosa and E. coli. This indicated that, except for E. coli and P. aeruginosa, moringa seed kernel extract might be utilized to treat infections caused by these species [57]. A recent study has been conducted, which states that only apolar extract obtained from seeds of M. oleifera showed anti-microbial activity against Gram-positive bacteria [58].

2.2. Anti-Inflammatory Activity

A significant anti-inflammatory effect was observed in different parts of M. oleifera (leaf, pods, flowers, and roots). It was observed that the isolated compound (4-[2-o-Acetyl-alpha -l-rahamnoslyloxy) benzyl] thiocynate from Moringa possessed nitric oxide inhibitory activity and was subsequently found to be effective in Raw264.7 cell lines [59]. A compound derived from M. oleifera roots, known as aurnatiamide acetate and 1,3-dibenzylurea, inhibited TNF-α production [60]. Active compounds such as tannins, phenols, alkaloids, flavanoids, carotenoids β-sitosterol, vanillin, and moringin have anti-inflammatory properties [16]. The M. oleifera fruit extract blocked nuclear factor kappa B (NF κB) translocation, and the chloroform extract was found to be cytotoxic at high concentrations (500–1000 µg/mL) [61]. M. oleifera leaves extract was used in mice for treating atopic dermatitis in human keratinocytes and was found to be effective in reducing the expression of mannose receptor mRNA, thymic stromal lymphopoietin, and retinoic acid-related orphan receptor γT in ear tissues (Figure 1) [62].
Figure 1. M. oleifera, as an oxidative and inflammatory marker, inhibits IKBα phosphorylation, thereby preventing NFKB (nuclear factor kappa B) inhibition. It prevents the nuclear translocation and dimerization of IkBα and NFKB, thereby inhibiting the formation of inflammatory proteins such as TNFα(tumor necrosis factor), COX-2(cyclooxygenase-2), IL6(interleukin -6), and iNos(inducible nitric oxide synthase) and thereby reducing the inflammation and curing other disorders like obesity, arthritis, cancer, diabetes, and ulcer.

2.3. Oxidative Stress

The results of M. oleifera were observed in methotrexate-induced mice. The study aimed to look into a probable palliative effect of M. oleifera extract on mice. The mice received the extract one week before administering methotrexate injection, and this treatment was continued for 12 days. The result showed that pretreatment with an extract of M. oleifera on mice poisoned with methotrexate could protect them from oxidative stress [63].
The antioxidant activity of ethanolic extract M. oleifera stems exhibited a protective effect against epidermal oxidative stress injury induced by H2O2 in keratinocytes. The result displayed that the stems showed antioxidant potential, and, therefore, can be used as an excellent and preventive source in animal epidermal oxidative stress injury [64].
The research investigated the antioxidant potential of Moringa leaves against diclofenac sodium-induced liver toxicity in animals. The researchers concluded that the extract was significantly effective against diclofenac-induced liver toxicity and, therefore, can be considered liver protective [65].

2.4. Anti-Oxidant Activity

Bioactive compounds such as glycosylates [66], isothiocyanates [46], thiocarbamates [67], flavonoids [68], and certain other compounds from Moringa pods have been investigated for reactive oxygen spices. The aqueous extract has been shown to be a potent free radical scavenger against free radicles [29]. Previous studies suggest that the antioxidant potential might be due to kaempferol, which is mainly found in plant leaves [27]. The synergistic outcome of Moringa was observed with piperine and curcumin on oxidative stress induced by beryllium toxicity in Wistar rats [69]. The alcoholic extract of the plant reduced glucose-induced cataractogenesis in isolated goat eye lenses by controlling GSH levels [70]. Myricetin, derived from the Moringa seed extract, has proved to be a better antioxidant than BHT (butylated hydroxytoluene) and alpha-tocopherol. M. oleifera leaf extract and compounds, such as isoquercetin, astragalin, and crypto-chlorogenic acid, help lower ROS in HEK-293 cells [71]. Moringa is also helpful in reducing plasma monoaldehyde (MDA) levels in fasting plasma glucose (FPG) concentration in healthy volunteers compared to the individuals fed with warm water. A dose-dependent upsurge in GSH and reduced MDA levels were observed with alcoholic extract of the plant without toxic effect till 100 mg/kg (Figure 1) [30].

2.5. Anti-Cancer Activity

Several parts of moringa (fruits, leaves, flowers, stems) have been shown to be beneficial against cancer, a deadly disease. The isolated compounds thiocarbamate and isothiocyanate from moringa act as inhibitors of tumor cells [31][72]. The dichloromethane fraction was found to be cytotoxic for MCF7 breast cancer cells [73]. Niazimincin has been projected as an effective chemopreventive agent in chemical carcinogenesis [28]. Alcoholic and hydro-methanolic extracts of fruits and leaves have shown significant tumor growth retardation in the melanoma mouse model [16]. Soluble cold distilled water from Moringa inhibited tumor cell growth and reduced ROS (reactive oxygen species) in cancer cells [29]. A recent study based on computational modelling suggests that M. oleifera contains rutin with the highest binding affinity with BRAC-1 (Breast Cancer Gene-1) [33].

2.6. Fertility and Anti-Fertility Activity

Adding to the list of beneficial effects of Moringa, the various parts of the plant possess fertility and abortion-inducing properties. The aqueous extract at a 200 and 400 mg/kg dose has been found to be more abortifacient and anti-fertility effects [28]. Recent studies on hot and cold extracts of leaves of M. oleifera propose that ingestion of Moringa before, after, and during pregnancy may lead to adverse fetal developmental outcomes by causing rigorous contraction of the uterine wall [74].

2.7. Hepatoprotective Activity

Among the numerous flavonoids (quercetin, kaempferol, isoquercetin, rhamnetin, etc.,) present in Moringa, quercetin in Moringa flowers is thought to be accountable for the hepatoprotective effect [28]. Methanolic extract at low dose showed changes in hepato-renal and hematological profile with significant changes in serum aminotransferase concentration, plasma cholesterol level, alkaline phosphate, bilirubin, and serum LPO levels. However, the higher dose of the extract altered total bilirubin, blood urea nitrogen, and non-protein nitrogen levels and decreased the clotting time [27]. Liver injuries induced by acetaminophen in Sprague-Dawley rats, where the standard drug taken was silymarin, Moringa showed similar hepatoprotective properties in these rats by dropping the levels of AST, ALT, and ALP [75]. The seeds were also found to be effective against carbon tetrachloride-induced liver fibrosis, as evidenced by a reduction in serum aminotransferase activity and globulin levels [76]. Treatment with this plant extract for about 21 days regularly as diet significantly reduced liver injury, and this effect was found due to alkaloid, quercetin, kaempferol, flavonoids, ascorbic acid, and benzyl glucosinolates in this plant [16].

2.8. Cardiovascular Activity

The freeze-dried aqueous and alcoholic extract of M. oleifera showed cardioprotective activity in animals induced with myocardial infarction by isoproterenol [77]. Chronic treatment of M. oleifera was effective on isoproterenol-induced hemodynamics and improved the levels of enzymes such as SOD, catalase, lactase dehydrogenase, glutathione peroxidase, and creatine kinase [77]. Butanolic extract has been proven to be a rich antioxidant source in rats with cardiac necrosis induced with isoproterenol. Moreover, it was found to significantly reduce inflammatory levels and myocardial necrosis due to the presence of the compound N-α-rhamnopyranosyl vincosamide [78]. Moringa leaves significantly lowered cholesterol levels by showing a protective effect on hypertensive rats. The active constituents believed to be responsible for this activity were identified as niazirmin A, niazirimin B, and niazimincin [16].

2.9. Anti-Ulcer/Gastroprotective Activity

Bisphenols and flavonoids found in moringa leaves showed a reduced level of ulcer index, duodenal ulcer, and stress ulcer in the ibuprofen-induced gastric ulcer model [16]. Moringa extract was shown to significantly reduce free radicals and neutralize the acidic behavior of gastric juice and have a protective effect on the development of gastric ulcer [79]. The presence of flavonoids in the plant has been shown to have a protective effect on ulcer formation by increasing capillary resistance and improving microcirculation, resulting in less cell injury [80].

2.10. Analgesic/Antipyretic Activity

Moringa leaf extract shows analgesic activity in almost all tree parts in central and peripheral animal models [16]. Multiple factions of alcoholic extracts such as petroleum ether, n-butanol, ethyl acetate, and dimethyl ether were found to have potent analgesic activity compared to standard aspirin [81]. At a dosage of 30–300 mg/kg, the polar and non-polar extract of leaves showed a remarkable drop in prostaglandin and bradykinin levels compared to the seed and root extract in a nociceptive study of formalin-induced paw edema [81]. The ether and ethyl acetate fractions of the seeds were studied in a hyperpyrexia model [82], keeping paracetamol as standard 200 mg/kg, and the extract proved to have the best antipyretic activity among all [29].

2.11. Neuropharmacological Activity

Previous results have proved that leaves extract reestablishes levels of monoamine in the brain and is very helpful in Alzheimer’s disease, while the in vitro activity of the ethanolic extract of the leaves showed an anticonvulsant effect on dopamine and norepinephrine levels, locomotor activity, and serotonin (5HT) in the brain in penicillin-induced convulsions [83][84]. The methanolic root extract in mice induced by pentobarbital sodium and diazepam has remarkable sedative effects on the CNS by improving sleep duration [19]. The toluene acetate fraction of the methanolic extract proved its potency as a possible nootropic agent [82]. The leaves have shown good anticonvulsant activity in a phenyl tetrazoline and maximal electric shock-induced model using male albino mice [83]. The aqueous extract of the roots blocked the epileptic seizures induced by penicillin in adult albino rats [84]. The ethanolic leaves extract exhibited anxiolytic properties, which were confirmed in behavioral experiments using the actophotometer and the rotarod device, respectively (Figure 2) [16].
Figure 2. The various phytoconstituents present in M oleifera are responsible for numerous neuroprotective effects. M. oleifera is responsible for upregulating synaptic activity, cholinergic activity, dopaminergic activity, signaling of NrF2 (Nuclear factor erythroid 2-related factor 2), and simultaneously decreasing beta-amyloid toxicity and phosphorylation of tau proteins.

2.12. Neuropathic Pain

The broad spectrum of phytoconstituents of the leaves extract of Moringa has led researchers to develop a herbal alternative for treating chronic neuropathic pain caused by constriction. The need to limit conventional analgesics for this disease. Diabetic rats inflicted with neuropathic pain caused by chronic constriction were used for the study. Tests conducted before and after treatment with moringa leaves showed that they significantly altered the neuropathic pain condition in diabetic rats. It suggests that the drop in oxidative stress might be the underlying mechanism in treating neuropathic pain and thus could be used as an effective novel source for the same [85].
A research team explored the bio-guided fractions of Moringa seed extract on a diabetes-induced neuropathic pain model. After conducting various oxidative and other experimental studies on induced and treated rats, the team concluded that the extract-treated rats exhibited reasonable glycemic control and antinociceptive properties and proved to be a powerful neuroprotective agent with a high margin of safety (Figure 5) [86].

2.13. Wound Healing Effect

A significant effect in studies on wound healing after incision or excision was demonstrated for ethyl acetate, and water extract of M. oleifera leaves at a 300 mg/kg dose [27]. Studies reported that in preclinical studies, leaves, seeds, and dried pulp extracts have shown effective enhancement of wound closure, granuloma rupture strength, and reduction of skin rupture strength in the scar area [87]. Leaf extracts have shown promising results in diabetic animals by improving the downregulation of inflammatory markers and increasing the vascular endothelial growth factor level in the injured tissue [16]. Compounds present in aqueous extract have shown a considerable effect on diabetic foot ulcers by downregulating the levels of various inflammatory markers [87]. The researcher conducted an in vitro assay to select the standardized extract with the highest potency, which was then converted into a film for wound healing. The result showed that the aqueous extract had the maximum cell proliferation and migration properties among the different extracts [88].

2.14. Immunomodulatory Activity

Methanolic extract of the plant contains active constituents such as isothiocyanate and glycoside cyanide, which exhibit immunostimulatory activity and effectively enhance immunity. The recent research suggests that various bioactive compounds have been used to treat various immune-related disorders such as cancer, hypertension, and diabetes, thereby enhancing host immunity [89].

2.15. Hematological Activity

M. oleifera has demonstrated its significant benefits in hematological activities. A randomized, double-blind study suggests that aqueous leaf extract effectively improves women’s low hemoglobin levels (8–12 g/dL) [90]. Another study showed that M. oleifera leaves, when taken for 14 days by healthy volunteers, significantly improved platelet counts [16].

2.16. Anti-Obesity Activity

In a study, oral treatment with leaf powder of M. oleifera for a duration of nearly 49 days was found to significantly reduce body mass index (BMI) in rats suffering from hypercholesterolemia [91]. The mechanistic approach behind this was the downregulation of mRNA expression of the hormones resistin and leptin and the concomitant increase in regulation of the gene adiponectin in rats [16]. A recent study revealed the mechanistic approach for the anti-obesity effect of M. oleifera. The plant significantly improved lipid profile by reducing body weight. It also regulated adipogenesis-related genes, increased glucose tolerance, and decreased levels of hormones such as vaspin, leptin, and resistin (Figure 3) [92].
Figure 3. M. oleifera as a promising anti-obesity agent. Various in-vitro findings suggest that supplements of M. oleifera cause direct inhibition of pancreatic lipase, thus reducing the conversion of triglycerides into simple. Moringa has fat storage regulation by upregulation of lipolysis-associated protein and down-regulating the expression of protein related to fat storage. It is also effective in the improvement of antioxidant levels. Besides these, Moringa is also responsible for increasing ghrelin levels and decreasing leptin, producing a feeling of satiety.

2.17. Anti-Allergic Activity

The ethanolic seeds extract reduced histamine release and also suppressed the anaphylaxis induced by anti-immunoglobulin G. The mechanism underlying this effect may be the membrane-stabilizing potential of mast cells in an oval albumin sensitization model [16].

2.18. Anti-Diabetic Activity

Moringa leaves showed excellent results in the glucose tolerance of Wistar and Goto-Kakizaki rats and also lowered blood glucose levels. The aqueous extract showed an antidiabetic effect in rats by controlling blood glucose levels, protein, sugar, and hemoglobin [29]. The leaves of the plant were found to lower glucose levels within three hours of intake, but not more than the standard drug glibenclamide. Moringa seeds, when administered orally, contain insulin-like proteins that have antigenic epitopes such as insulin and exhibit antihyperglycemic activity [93]. Leaf extracts of the plant also have antidiabetic activity as they increased CAT and MDA levels, reduced FPG levels, hemoglobin levels, LDL-C, and VLDL-C in type 2 diabetic patients and, most importantly, increased insulin levels in healthy subjects [94]. The seed extract of the plant reduced LPO levels and amplified the antioxidant effect in mice induced with streptozotocin, the seed extract was also able to reduce IgG, IgA, and IL -6 parameters and pancreatic β-cell activity, and it was suggested that the bioactive compound responsible for this effect were quercetin, kaempferol, glucomoringin, chlorogenic acid, and isothiocyanates [95].

2.19. Diuretic Activity

The alcoholic and aqueous root extract of M. oleifera significantly affects calcium oxalate urolithiasis in male rats. This reduction was observed due to the decrease in the retention level of oxalates, calcium and phosphates as well as serum urea nitrogen, creatinine, and uric acid [5].

2.20. Angiotensin Converting Enzyme (ACE) Activity

Compounds such as niazimin-A, niazicin-A, and niaziminin-B are stated to be present in the M. oleifera plant extract. These compounds were found to have potent antihypertensive activity when targeted to (ACE), an important enzyme of the renin-angiotensin system. The researchers observed this activity by protein–ligand docking and found that the compounds have a high affinity for the angiotensin-converting enzyme compared with captopril and enalapril (standard drug) [96]. The angiotensin enzyme rennin plays a prominent role in regulating blood pressure and leading to diseases such as hypertension, kidney disease, and other cardiovascular diseases. The study found that the role of M. oleifera with two other plants (Azadirachta indica and Hibiscus sabdariffa) inhibited the enzyme with percentage inhibition (71.8%, 74%, and 73.4%) compared to standard drugs (captopril and enalapril). The compound responsible for this activity of Moringa was termed β-sitosterol [97].

2.21. Anti-Venom Effect

The leaves of the plant extract have been shown to be effective against the venom of Naja Nigricollis (a snake species) in rats. This snake’s venom contains potent neurotoxins that cause the degradation of phospholipids at the plasma membrane, affecting the normal neurotransmission process and causing hemolysis and hemorrhage. The results showed that Moringa extract effectively cured acute anemia, and a remarkable increase in micronucleated polychromatic erythrocytes was observed in rats treated with M. oleifera [98].

2.22. Cytotoxicity Effect

The cytotoxic potential of M. oleifera on human mesenchymal myeloma cell lines is observed in methanolic extract. The results of the extracts showed a higher ID50 value than other extracts. The researchers also found that the alkaloids and flavonoids contained in the plant showed some similarity to vincristine and vinblastine by random experiments. Therefore, the plant can be recommended for the herbal treatment of myeloma patients [31].
It was found that the ethanolic leaves extract of M. oleifera contains active constituents that can alleviate cyclophosphamide-induced testicular toxicity by promoting genes associated with the functional integrity of spermatozoa and enlargement of DNA in spermatogonia. Therefore, the administration of the extract not only improved blood and intestinal hormone levels but also modulated the expression of genes responsible for Sertoli and spermatogonial cells [99].

References

  1. Stohs, S.J.; Hartman, M.J. Review of the Safety and Efficacy of Moringa oleifera. Phytother. Res. 2015, 29, 796–804.
  2. Aekthammarat, D.; Pannangpetch, P.; Tangsucharit, P. Moringa oleifera leaf extract lowers high blood pressure by alleviating vascular dysfunction and decreasing oxidative stress in L-NAME hypertensive rats. Phytomedicine 2019, 54, 9–16.
  3. Bhat, S.K.; Joy, A.E. Antianxiety effect of ethanolic extract of leaves of Moringa oleifera in Swiss albino mice. Arch. Med. Health Sci. 2014, 2, 5–7.
  4. Misra, A.; Srivastava, S.; Srivastava, M. Evaluation of antidiarrheal potential of Moringa oleifera (Lam.) leaves. J. Pharmacogn. Phytochem. 2014, 2, 43–46.
  5. Tahkur, R.S.; Soren, G.; Pathapati, R.M.; Buchineni, M. Diuretic activity of Moringa oleifera leaves extract in swiss albino rats. J. Pharm. Innov. 2016, 5, 8–10.
  6. Woldeyohannes, M.G.; Eshete, G.T.; Abiye, A.A.; Hailu, A.E.; Huluka, S.A.; Tadesse, W.T. Antidiarrheal and Antisecretory Effect of 80% Hydromethanolic Leaf Extract of Moringa stenopetala Baker f. in Mice. Biochem. Res. Int. 2022, 2022, 2090–2247.
  7. Zhang, Y.; Peng, L.; Li, W.; Dai, T.; Nie, L.; Xie, J.; Ai, Y.; Li, L.; Tian, Y.; Sheng, J. Polyphenol Extract of Moringa oleifera Leaves Alleviates Colonic Inflammation in Dextran Sulfate Sodium-Treated Mice. Evid. Based Complement. Altern. Med. 2020, 2020, 6295402.
  8. Posmontier, B. The medicinal qualities of Moringa oleifera. Holist. Nurs. Pr. 2011, 25, 80–87.
  9. Gopalakrishnan, L.; Doriya, K.; Kumar, D.S. Moringa oleifera: A review on nutritive importance and its medicinal application. Food Sci. Hum. Wellness 2016, 5, 49–56.
  10. Karadi, R.V.; Gadge, N.B.; Alagawadi, K.R.; Savadi, R.V. Effect of Moringa oleifera Lam. root-wood on ethylene glycol induced urolithiasis in rats. J. Ethnopharmacol. 2006, 105, 306–311.
  11. Ghasi, S.; Nwobodo, E.; Ofili, J.O. Hypocholesterolemic effects of crude extract of leaf of Moringa oleifera Lam in high-fat diet fed wistar rats. J. Ethnopharmacol. 2000, 69, 21–25.
  12. Paliwal, R.; Sharma, V.; Pracheta. A Review on Horse Radish Tree (Moringa oleifera): A Multipurpose Tree with High Economic and Commercial Importance. Asian J. Biotechnol. 2011, 3, 317–328.
  13. Debnath, S.; Guha, D. Role of Moringa oleifera on enterochromaffin cell count and serotonin content of experimental ulcer model. Indian J. Exp. Biol. 2007, 45, 726–731.
  14. Mahajan, S.G.; Mali, R.G.; Mehta, A.A. Protective Effect of Ethanolic Extract of Seeds of Moringa oleifera Lam. Against Inflammation Associated with Development of Arthritis in Rats. J. Immunotoxicol. 2007, 4, 39–47.
  15. Rathi, B.S.; Bodhankar, S.L.; Baheti, A.M. Evaluation of aqueous leaves extract of Moringa oleifera Linn for wound healing in albino rats. Indian J. Exp. Biol. 2006, 44, 898–901.
  16. Bhattacharya, A.; Tiwari, P.; Sahu, P.K.; Kumar, S. A review of the phytochemical and pharmacological characteristics of Moringa oleifera. J. Pharm. Bioallied Sci. 2018, 10, 181–191.
  17. Pandey, A.; Pandey, R.D.; Tripathi, P.; Gupta, P.P.; Haider, J.; Bhatt, S.; Singh, A.V. Moringa oleifera Lam. (Sahijan)—A plant with a plethora of diverse therapeutic benefits: An Updated Retrospection. Int. J. Med. Aromat. 2012, 1, 1–8.
  18. Meireles, D.; Gomes, J.; Lopes, L. A review of properties, nutritional and pharmaceutical applications of Moringa oleifera: Integrative approach on conventional and traditional Asian medicine. Adv. Tradit. Med. 2020, 20, 495–515.
  19. Liu, W.L.; Wu, B.F.; Shang, J.H.; Wang, X.F.; Zhao, Y.L.; Huang, A.X. Moringa oleifera seed ethanol extract and its active component kaempferol potentiate pentobarbital-induced sleeping behaviours in mice via a GABAergic mechanism. Pharm. Biol. 2022, 60, 810–824.
  20. Gothai, S.; Arulselvan, P.; Tan, W.S.; Fakurazi, S. Wound healing properties of ethyl acetate fraction of Moringa oleifera in normal human dermal fibroblasts. J. Intercult. Ethnopharmacol. 2016, 5, 1–6.
  21. Toma, A.; Deyno, S. Phytochemistry and pharmacological activities of Moringa oleifera. Indian, J. Pharmacol. 2014, 4, 222–231.
  22. Tripathi, B. Charaka Samhita, of Agnivesa, 3rd ed.; Chaukambha Surbharati Prakashan: Varanasi, India, 1994; pp. 15–20.
  23. Gupta, K.A. Astanga Hridaya, 13th ed.; Chaukambha Sanskrit Sansthan: Varanasi, India, 2000; pp. 5–17.
  24. Sharma, H.R. Kashyap Samhita, 3rd ed.; Chaukhambha Sanskrit Sansthan: Varanasi, India, 2010; pp. 2–4.
  25. Srikanthmurthy, K.R. SharangadharaSamhita, 12th ed.; Master Kheladi Lal and Sons: Benaras City, India, 1933; pp. 14–20.
  26. Laksmipati, V.S. Yogaratnakara, 7th ed.; Chaukambha Sanskrit Sansthan: Varanasi, India, 1999; pp. 1–5.
  27. Mishra, G.; Singh, P.; Verma, R.; Kumar, S.; Srivastav, S.; Jha, K.K.; Khosa, R.L. Traditional uses, phytochemistry and pharmacological properties of Moringa oleifera plant: An overview. Der Pharmacia Lett. 2011, 3, 141–164.
  28. Upadhyay, P.; Yadav, M.K.; Mishra, S.; Sharma, P.; Purohit, S. Moringa oleifera: A review of the medical evidence for its nutritional and pharmacological properties. Int. J. Res. Pharm. Sci. 2015, 5, 12–16.
  29. Singh, A.; Navneet. Ethnomedicinal, pharmacological and antimicrobial aspects of Moringa oleifera lam.: A review. J. Phytopharmacol. 2018, 7, 45–50.
  30. Banik, S.; Biswas, S.; Karmakar, S. Extraction, purification, and activity of protease from the leaves of Moringa oleifera. F1000Research 2018, 7, 1151.
  31. Parvathy, M.V.S.; Umamaheshwari, A. Cytotoxic Effect of Moringa oleifera Leaf Extracts on Human Multiple Myeloma Cell Lines. Trends Medical Res. 2007, 2, 44–50.
  32. Venkatesh, N.; Devi, K.G.; Venkateswarlu, G.; Sudhakar, A.M.S. effect of hydroalcoholic extract of Moringa oleifera leaves on fertility hormone and sperm quality of male albino rats. Int. J. Curr. Med. Pharm. Res. 2019, 1, 83–87.
  33. Balogun, T.A.; Buliamimu, K.D.; Chukwudozie, O.S.; Tiamiyu, Z.A.; Idowu, T.J. Anticancer Potential of Moringa oleifera on BRCA-1 Gene: Systems Biology. Bioinform. Biol. Insights. 2021, 15, 11779322211010703.
  34. Alam, P.; Elkholy, S.F.; Mahfouz, S.A.; Alam, P.; Sharaf-Eldin, M.A. HPLC based estimation and extraction of rutin, quercetin and gallic acid in Moringa oleifera plants grown in Saudi Arabia. J. Chem. Pharm. 2016, 8, 1243–1246.
  35. Singh, B.N.; Singh, B.R.; Singh, R.L. Oxidative DNA damage protective activity, antioxidant and anti-quorum sensing potentials of Moringa oleifera. Food Chem. Toxicol. 2009, 47, 1109–1116.
  36. Ndong, M.; Uehara, M.; Katsumata, S.; Suzuki, K. Effects of oral administration of Moringa oleifera Lam on glucose tol-erance in Goto-Kakizaki and Wistar rats. J. Clin. Biochem. Nutri. 2007, 40, 229–233.
  37. Zhang, M.; Hettiarachchy, S.N.; Horax, R.; Kannan, A.; Praisoody, M.D.A.; Muhundan, A.; Mallangi, C.R. Phytochemicals, antioxidant and antimicrobial activity of Hibiscus sabdariffa, Centella asiatica, Moringa oleifera and Murraya koenigii leaves. J. Med. Plants Res. 2011, 5, 6672–6680.
  38. Leone, A.; Spada, A.; Battezzati, A.; Schiraldi, A.; Aristil, J.; Bertoli, S. Cultivation, genetic, ethnopharmacology, phytochemistry and pharmacology of Moringa oleifera leaves: An overview. Int. J. Mol. Sci. 2015, 16, 12791–12835.
  39. Sharifi-Rad, J.; Quispe, C.; Castillo, C.M.S.; Caroca, R.; Lazo-Vélez, M.A.; Antonyak, H.; Polishchuk, A.; Lysiuk, R.; Oliinyk, P.; Masi, L.D.; et al. Phytochemicals for the Prevention and Treatment of Oxidative Stress-Induced Diseases. World J. Gastrointest. Endosc. 2022, 22, 1–9.
  40. Zduńska, K.; Dana, A.; Kolodziejczak, A.; Rotsztejn, H. Antioxidant Properties of Ferulic Acid and Its Possible Application. Skin Pharmacol. Physiol. 2018, 31, 332–336.
  41. Chung, T.W.; Moon, S.K.; Chang, Y.C.; Ko, J.H.; Lee, Y.C.; Cho, G.; Kim, S.H.; Kim, J.G.; Kim, C.H. Novel and therapeutic effect of caffeic acid and caffeic acid phenyl ester on hepatocarcinoma cells: Complete regression of hepatoma growth and metastasis by dual mechanism. FASEB J. 2004, 18, 1670–1681.
  42. Pandi, A.; Kalappan, V.M. Pharmacological and therapeutic applications of Sinapic acid—An updated review. Mol. Biol. Rep. 2021, 48, 3733–3745.
  43. Alhakmani, F.; Kumar, S.; Khan, S.A. Estimation of total phenolic content, in-vitro antioxidant and anti-inflammatory activity of flowers of Moringa oleifera. Asian Pac. J. Trop. Biomed. 2013, 3, 623–627.
  44. Bennour, N.; Mighri, H.; Eljani, H.; Zammouri, T.; Akrout, A. Effect of Solvent Evaporation Method on Phenolic Compounds and the Antioxidant Activity of Moringa oleifera Cultivated in Southern Tunisia. S. Afr. J. Bot. 2020, 129, 181–190.
  45. Riaz, A.; Rasul, A.; Hussain, G.; Zahoor, M.K.; Jabeen, F.; Subhani, Z.; Younis, T.; Ali, M.; Sarfraz, I.; Selamoglu, Z. Astragalin: A Bioactive Phytochemical with Potential Therapeutic Activities. Adv. Pharmacol. Sci. 2018, 2018, 9794625.
  46. Borgonovo, G.; De Petrocellis, L.; Schiano Moriello, A.; Bertoli, S.; Leone, A.; Battezzati, A.; Mazzini, S.; Bassoli, A. Moringin, A Stable Isothiocyanate from Moringa oleifera, activates the Somatosensory and Pain Receptor TRPA1 Channel In Vitro. Molecules 2020, 25, 976.
  47. Liao, P.-C.; Lai, M.-H.; Hsu, K.-P.; Kuo, Y.-H.; Chen, J.; Tsai, M.-C.; Li, C.-X.; Yin, X.-J.; Jeyashoke, N.; Chao, L.K.-P. Identification of β-Sitosterol as in Vitro Anti-Inflammatory Constituent in Moringa oleifera. J. Agric. Food Chem. 2018, 66, 10748–10759.
  48. Sari, K.; Sirajuddin, S.; Maddeppungeng, M.; Hadju, V.; Saleh, A.; Hastuti, H. Moringa oleifera Intake during Pregnancy and Breastfeeding toward Docosahexaenoic Acid and Arachidonic Acid Levels in Breast Milk. Open Access Maced. J. Med. Sci. 2020, 8, 757–761.
  49. Snehal, M.; Parag, G.; Jyotsna, W.; Satyanarayan, N.N. Intensified synthesis of structured lipids from oleic acid rich moringa oil in the presence of supercritical CO2. Food Bioprod. Process. 2020, 112, 86–95.
  50. Kaur, G.; Invally, M.; Sanzagiri, R.; Buttar, H.S. Evaluation of the antidepressant activity of Moringa oleifera alone and in combination with fluoxetine. J. Ayurveda Integr. Med. 2015, 6, 273–279.
  51. Korbecki, J.; Bajdak-Rusinek, K. The effect of palmitic acid on inflammatory response in macrophages: An overview of molecular mechanisms. Inflamm. Res. 2019, 68, 915–932.
  52. Rue, E.A.; Rush, M.D.; Van Breemen, R.B. Procyanidins: A comprehensive review encompassing structure elucidation via mass spectrometry. Phytochem. Rev. 2018, 17, 1–16.
  53. Maurya, S.K.; Singh, A.K. Clinical Efficacy of Moringa oleifera Lam. Stems Bark in Urinary Tract Infections. Int. Sch. Res. Not. 2014, 2014, 906843.
  54. Padla, E.P.; Solis, L.T.; Levida, R.M.; Shen, C.C.; Ragasa, C.Y. Antimicrobial isothiocyanates from the seeds of Moringa oleifera Lam. Z. Für Nat. C 2012, 67, 557–564.
  55. Ahmadua, T.; Ahmad, K.; Ismail, S.I.; Rashed, O.; Asib, N.; Omar, D. Antifungal efficacy of moringa oliefera leaves and seed extract against Botrytis cinerea causing graymold disease of tomato. Braz. J. Biol. 2020, 81, 1007–1022.
  56. Moodley, J.S.; Krishna, S.B.N.; Pillay, K. Green synthesis of silver nanoparticles from Moringa oleifera leaf extracts and its antimicrobial potential. Adv. Nat. Sci. Nanosci. Nanotechnol. 2018, 9, 1–10.
  57. Dinesha, B.L.; Nidoni, U.; Ramachandra., C.T.; Naik, N.; Sankalpa, K.B. Effect of extraction methods on physicochemical, nutritional, antinutritional, antioxidant and antimicrobial activity of Moringa (Moringa oleifera Lam.) seed kernel oil. J. Appl. Nat. Sci. 2018, 10, 287–295.
  58. Anzano, A.; De Falco, B.; Ammar, M.; Ricciardelli, A.; Grauso, L.; Sabbah, M.; Capparelli, R.; Lanzotti, V. Chemical Analysis and Antimicrobial Activity of Moringa oleifera Lam. Leaves and Seeds. Molecules 2022, 27, 8920.
  59. Tan, W.S.; Arulselvan, P.; Karthivashan, G.; Fakurazi, S. Moringa oleifera Flower Extract Suppresses the Activation of Inflammatory Mediators in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages via NF-κB Pathway. Mediators Inflamm. 2015, 2015, 720171.
  60. Cuellar-Núñez, M.L.; Gonzalez de Mejia, E.; Loarca-Piña, G. Moringa oleifera leaves alleviated inflammation through downregulation of IL- 2, IL- 6, and TNF- α in a colitis associated colorectal cancer model. Int. Food Res. J. 2021, 144, 110318.
  61. Abdel-Daim, M.M.; Khalil, S.R.; Awad, A.; Abu Zeid, E.H.; El-Aziz, R.A.; El-Serehy, H.A. Ethanolic Extract of Moringa oleifera Leaves Influences NF-κB Signaling Pathway to Restore Kidney Tissue from Cobalt-Mediated Oxidative Injury and Inflammation in Rats. Nutrients 2020, 12, 1031.
  62. Choi, E.J.; Debnath, T.; Tang, Y.; Ryu, Y.B.; Moon, S.H.; Kim, E.K. Topical application of Moringa oleifera leaf extract ameliorates experimentally induced atopic dermatitis by the regulation of Th1/Th2/Th17 balance. Biomed. Pharmacother. 2016, 84, 870–877.
  63. Soliman, M.M.; Al-Osaimi, S.H.; Hassan Mohamed, E.; Aldharani, A.; Alkhedaide, A.; Althobaiti, F.; Mohamed, W.A. Protective effects of Moringa oleifera Leaf Extract against Methotrexate-Induced Oxidative Stress and Apoptosis on Mouse Spleen. Evid. -Based Complement. Altern. Med. 2020, 2020, 6738474.
  64. Zhou, Y.; Yang, W.; Li, Z.; Luo, D.; Li, W.; Zhang, Y.; Wang, X.; Fang, M.; Chen, Q.; Jin, X. Moringa oleifera stem extract protect skin keratinocytes against oxidative stress injury by enhancement of antioxidant defense systems and activation of PPARα. Biomed. Pharmacother. 2018, 107, 44–53.
  65. El-Hadary, A.E.; Ramadan, M.F. Antioxidant traits and protective impact of Moringa oleifera leaf extract against diclofenac sodium-induced liver toxicity in rats. J. Food Biochem. 2019, 43, e12704.
  66. Nunthanawanich, P.; Sompong, W.; Sirikwanpong, S.; Mäkynen, K.; Adisakwattana, S.; Dahlan, W.; Ngamukote, S. Moringa oleifera aqueous leaf extract inhibits reducing monosaccharide-induced protein glycation and oxidation of bovine serum albumin. Springer Plus. 2016, 5, 1098.
  67. Albuquerque Costa, R.; de Sousa, O.V.; Hofer, E.; Mafezoli, J.; Barbosa, F.G.; Vieira, R. Thiocarbamates from Moringa oleifera Seeds Bioactive against Virulent and Multidrug-Resistant Vibrio Species. BioMed Res. Int. 2017, 2017, 7963747.
  68. Vergara-Jimenez, M.; Almatrafi, M.M.; Fernandez, M.L. Bioactive Components in Moringa oleifera Leaves Protect against Chronic Disease. Antioxidant 2017, 6, 91.
  69. Agrawal, N.D.; Nirala, S.K.; Shukla, S.; Mathur, R. Co-administration of adjuvants along with Moringa oleifera attenuates beryllium-induced oxidative stress and histopathological alterations in rats. Pharm. Biol. 2015, 53, 1465–1473.
  70. Sasikala, V.; Rooban, B.N.; Priya, S.G.; Sahasranamam, V.; Abraham, A. Moringa oleifera prevents selenite-induced cataractogenesis in rat pups. J. Ocul. Pharmacol. Ther. 2010, 26, 441–447.
  71. Vongsak, B.; Mangmool, S.; Gritsanapan, W. Antioxidant Activity and Induction of mRNA Expressions of Antioxidant Enzymes in HEK-293 Cells of Moringa oleifera Leaf Extract. Planta Med. 2015, 81, 1084–1089.
  72. Guevara, A.P.; Vargas, C.; Sakurai, H.; Fujiwara, Y.; Hashimoto, K.; Maoka, T.; Kozuka, M.; Ito, Y.; Tokuda, H.; Nishino, H. An antitumor promoter from Moringa oleifera Lam. Mutat. Res. 1999, 440, 181–188.
  73. Mohd Fisall, U.F.; Ismail, N.Z.; Adebayo, I.A.; Arsad, H. Dichloromethane fraction of Moringa oleifera leaf methanolic extract selectively inhibits breast cancer cells (MCF7) by induction of apoptosis via upregulation of Bax, p53 and caspase 8 expressions. Mol. Biol. Rep. 2021, 48, 4465–4475.
  74. Attah, A.F.; Moody, J.O.; Sonibare, M.A.; Salahdeen, H.H.; Akindele, O.O.; Nnamani, P.O.; Diyaolu, O.A.; Raji, Y. Aqueous extract of Moringa oleifera leaf used in Nigerian ethnomedicine alters conception and some pregnancy outcomes in Wistar rat. S. Afr. J. Bot. 2020, 129, 255–262.
  75. Sharifudin, S.A.; Fakurazi, S.; Hidayat, M.T.; Hairuszah, I.; Aris, M.; Moklas, M.; Arulselvan, P. Therapeutic potential of Moringa oleifera extracts against acetaminophen-induced hepatotoxicity in rats. Pharm. Biol. 2013, 51, 279–288.
  76. Hamza, A.A. Ameliorative effects of Moringa oleifera Lam seed extract on liver fibrosis in rats. Food Chem. Toxicol. 2010, 48, 345–355.
  77. Nandave, M.; Ojha, S.K.; Joshi, S.; Kumari, S.; Arya, D.S. Moringa oleifera leaf extract prevents isoproterenol-induced myocardial damage in rats: Evidence for an antioxidant, antiperoxidative, and cardioprotective intervention. J. Med. Food. 2009, 12, 47–55.
  78. Panda, S.; Kar, A.; Sharma, P.; Sharma, A. Cardioprotective potential of N,alpha-L-rhamnopyranosyl vincosamide, an indole alkaloid, isolated from the leaves of Moringa oleifera in isoproterenol induced cardiotoxic rats: In vivo and in vitro studies. Bioorganic Med. Chem. Lett. 2012, 23, 959–962.
  79. Ijioma, S.N.; Nwaogazi, E.N.; Nwankwo, A.A.; Oshilonya, H.; Ekeleme, C.M.; Oshilonya, L.U. Histological exhibition of the gastroprotective effect of Moringa oleifera leaf extract. Comp. Clin. Pathol. 2018, 27, 327–332.
  80. Mallya, R.; Chatterjee, P.K.; Vinodini, N.A.; Chatterjee, P.; Mithra, P. Moringa oleifera Leaf Extract: Beneficial Effects on Cadmium Induced Toxicities—A review. J. Clin. Diagn. Res. 2017, 11, CE01.
  81. Martínez-Gonzálezb, C.L.; Martíneza, L.; Martínez-Ortizb, E.J.; González-Trujanoa, M.E.; Déciga-Camposc, M.; Ventura-Martínezd, R.; Díaz-Revale, I. Moringa oleifera, a species with potential analgesic and anti-inflammatory activities. Biomed. Pharmacother. 2017, 87, 482–488.
  82. Mohan, M.; Kaul, N.; Punekar, A.; Girnar, R.; Junnare, P.; Patil, L. Nootropic activity of Moringa oleifera leaves. J. Nat. Remedies 2005, 5, 59–62.
  83. Amrutia, J.N.; Lala, M.; Srinivasa, U.; Shabaraya, A.R.; Semuel, M.R. Anticonvulsant activity of Moringa oleifera leaf. Int. Res. J. Pharm. 2011, 2, 160–162.
  84. Ray, K.; Guha, D. Effect of Moringa oleifera root extract on penicillin-induced epileptic rats. Biog. Amines 2005, 19, 223–231.
  85. Khongrum, J.; Wattanathorn, J.; Muchimapura, S.; Thukhum-mee, W.; Thipkaew, C.; Wannanon, P.; Tong-Un, T. Moringa oleifera Leaves Extract Attenuates Neuropathic Pain Induced by Chronic Constriction Injury. Am. J. Appl. Sci. 2012, 9, 1182–1187.
  86. Raafat, K.; Hdaib, F. Neuroprotective Effects of Moringa oleifera: Bio-guided GC-MS Identification of Active Compounds in Diabetic Neuropathic Pain Model. Chin. J. Integr. Med. 2017. Online ahead of print.
  87. Muhammad, A.A.; Arulselvan, P.; Cheah, P.S.; Abas, F.; Fakurazi, S. Evaluation of wound healing properties of bioactive aqueous fraction from Moringa oleifera Lam on experimentally induced diabetic animal model. Drug Des. Devel. Ther. 2016, 10, 1715–1730.
  88. Awodele, O.; Oreagba, I.A.; Odoma, S.; Jaime, A.; Da Silva, T.; Osunkalu, V.O. Toxicological evaluation of the aqueous leaf extract of Moringa oleifera Lam. (Moringaceae). J. Ethnopharmacol. 2012, 139, 330–336.
  89. Mehwish, H.M.; Rajoka, M.S.; Xiong, Y.; Zheng, K.; Xiao, H.; Liu, Z.; Zhu, Q.; He, Z. Moringa oleifera—A Functional Food and Its Potential Immunomodulatory Effects. Food Rev. Int. 2020, 38, 1533–1552.
  90. Suzana, D.; Suyatna, F.D.; Andrajati, R.; Sari, S.P.; Mun’im, A. Effect of Moringa oleifera leaves extract against hematology and blood biochemical value of patients with iron deficiency anaemia. J. Young Pharm. 2017, 9, 79–84.
  91. Bais, S.; Singh, G.S.; Sharma, R. Anti-obesity and hypolipidemic activity of Moringa oleifera leaves against high fat diet-induced obesity in rats. Adv Biol. 2014, 2014, 162914.
  92. Redha, A.A.; Perna, S.; Riva, A.; Petrangolini, G.; Peroni, G.; Nichetti, M.; Iannello, G.; Naso, M.; Faliva, M.A.; Rondanelli, M. Novel insights on anti-obesity potential of the miracle tree, Moringa oleifera: A systematic review. J. Funct. Foods 2021, 84, 104600.
  93. Al-maliki, A.; El Rabey, H.A. The Antidiabetic Effect of Low Doses of Moringa oleifera Lam. Seeds on Streptozotocin Induced Diabetes and Diabetic Nephropathy in Male Rats. Biomed Res. Int. 2015, 2015, 381040.
  94. Villarruel-López, A.; López-de la Mora, D.A.; Vázquez-Paulino, O.D.; Puebla-Mora, A.G.; Torres-Vitela, M.R.; Guerrero-Quiroz, L.A.; Nuño, K. Effect of Moringa oleifera consumption on diabetic rats. BMC Complement. Altern. Med. 2018, 18, 120–127.
  95. Azad, S.B.; Ansari, P.; Azam, S.; Hossain, S.M.; Shahid, M.I.; Hasan, M.; Hannan, J. Anti-hyperglycaemic activity of Moringa oleifera is partly mediated by carbohydrase inhibition and glucose-fibre binding. Biosci. Rep. 2017, 37, BSR20170059.
  96. Khan, H.; Jaiswal, V.; Kulshreshtha, S.; Khan, A. Potential Angiotensin Converting Enzyme Inhibitors from Moringa oleifera. Recent Patents Biotechnol. 2019, 13, 239–248.
  97. Khan, H.; Hussain, T.; Kataria, M.; Seth, A.; Malik, M.; Dash, A.; Chand, S.; Khan, M. Role of selective Bioactive Compounds as an Angiotensin Converting Enzyme Inhibitor. Res. Sq. 2020, 7, 1–25.
  98. Adeyi, A.O.; Ajisebiola, S.B.; Adeyi, E.O.; Alimba, C.G.; Okorie, U.G. Antivenom activity of Moringa oleifera leave against pathophysiological alterations, somatic mutation and biological activities of Naja nigricollis venom. Sci. Afr. 2020, 8, 68–76.
  99. Nayak, G.; Rao, A.; Mullick, P.; Mutalik, S.; Kalthur, S.G.; Adiga, S.K.; Kalthur, G. Ethanolic extract of Moringa oleifera leaves alleviate cyclophosphamide induced testicular toxicity by improving endocrine function and modulating cell specific gene expression in mouse testis. J Ethnopharmacol. 2020, 259, 112922.
More
Information
Contributors MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : , , , , , , ,
View Times: 774
Revisions: 3 times (View History)
Update Date: 13 Feb 2023
1000/1000
Video Production Service