Topic Review
Green Tea Catechin EGCG-Sensing Receptor
The body is equipped with a “food factor-sensing system” that senses food factors, such as polyphenols, sulfur-containing compounds, and vitamins, taken into the body, and plays an essential role in manifesting their physiological effects. For example, (−)-epigallocatechin-3-O-gallate (EGCG), the representative catechin in green tea (Camellia sinensi L.), exerts various effects, including anti-cancer, anti-inflammatory, and anti-allergic effects, when sensed by the cell surficial protein 67-kDa laminin receptor (67LR). 
  • 38
  • 19 Aug 2022
Topic Review
Golden Syrian Hamster Models for Cancer Research
The golden Syrian hamster (Mesocricetus auratus) has long been a valuable rodent model of human diseases, especially infectious and metabolic diseases. Hamsters have also been valuable models of several chemically induced cancers such as the DMBA-induced oral cheek pouch cancer model.
  • 11
  • 19 Aug 2022
Topic Review
Targeted Therapy for HER2-Positive Breast Cancer
The development of several antiHuman Epidermal Growth Factor Receptor 2 (HER2) treatments over the last few years has improved the landscape of HER2-positive breast cancer. Despite this, relapse is still the main issue in HER2-positive breast cancer. The reasons for therapeutic failure lie in the heterogeneity of the disease itself, as well as in the drug resistance mechanisms.
  • 25
  • 19 Aug 2022
Topic Review
Efficacy of Auto-CAR T Cell Therapy in Lymphoma
While more than half of non-Hodgkin lymphomas (NHL) can be cured with modern frontline chemoimmunotherapy regimens, outcomes of relapsed and/or refractory (r/r) disease in subsequent lines remain poor, particularly if considered ineligible for hematopoietic stem cell transplantation. Hence, r/r NHLs represent a population with a high unmet medical need. This therapeutic gap has been partially filled by adoptive immunotherapy. CD19-directed autologous chimeric antigen receptor (auto-CAR) T cells have been transformative in the treatment of patients with r/r B cell malignancies.
  • 11
  • 19 Aug 2022
Topic Review
CFTR and Gastrointestinal Cancers
Cystic Fibrosis (CF) is a disease caused by mutations in the CFTR gene that severely affects the lungs as well as extra-pulmonary tissues, including the gastrointestinal (GI) tract. CFTR dysfunction resulting from either mutations or the downregulation of its expression has been shown to promote carcinogenesis. An example is the enhanced risk for several types of cancer in patients with CF, especially cancers of the GI tract. CFTR also acts as a tumor suppressor in diverse sporadic epithelial cancers in many tissues, primarily due to the silencing of CFTR expression via multiple mechanisms, but especially due to epigenetic regulation. cystic fibrosis; CFTR; gastrointestinal cancers; tumor suppressor gene
  • 7
  • 18 Aug 2022
Topic Review
Anesthetics and Long Term Cancer Outcomes
Anesthetics are chemical factors with the potential to induce epigenetic effects. With regard to the nervous system, for example, this is supported by the fact that anesthetics are neurotoxins sharing many molecular mechanisms of action with alcohol and cocaine.
  • 11
  • 18 Aug 2022
Topic Review
Cyclin-Dependent Kinases Pathway Dysregulation in Soft Tissue Sarcoma
Soft tissue sarcomas (STSs) are rare malignant conditions with more than 70 subtypes that are difficult to treat, especially in advanced or metastatic states. Next-generation sequencing technologies have provided comprehensive information and developed personalized medicine for treating cancer in general and STSs in particular. Growing knowledge of diverse gene alterations and biomolecular targets in various subtypes of STSs raises hope for novel treatment approaches and heralds a paradigm shift in the treatment of STSs. Activated cyclin-dependent kinases (CDKs) appear to play a critical role in sarcoma development and represent important targets for sarcoma therapy. 
  • 14
  • 18 Aug 2022
Topic Review
Current Challenges in Breast Implantation
Breast implantation (BI) is the most common plastic surgery worldwide performed among women. Generally, BI is performed both in aesthetic and oncoplastic procedures. 
  • 18
  • 18 Aug 2022
Topic Review
Functional Precision Oncology on Glioblastoma
Glioblastoma remains the most malignant and intrinsically resistant brain tumour in adults. Precision oncology refers to the evaluation of treatment efficacies and vulnerabilities of (ex vivo) living tumor cells in a highly personalized way. precision oncology aims at identifying effective therapeutic approaches based on properties (biomarkers) that are specific to each patient’s tumor.
  • 17
  • 17 Aug 2022
Topic Review
Cancer Immunotherapy and Delivery System
Immunotherapy is a powerful clinical strategy for the treatment of various diseases, including cancer, and an understanding of cancer immunology is important to the optimization of this strategy to achieve higher efficacy. 
  • 31
  • 15 Aug 2022
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