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Topic Review
Bitter Phytochemicals in Skin Disease Treatment
Skin diseases represent a global healthcare challenge due to their rising incidence and substantial socio-economic burden. While biological, immunological, and targeted therapies have brought a revolution in improving quality of life and survival rates for certain dermatological conditions, there remains a stringent demand for new remedies. Nature has long served as an inspiration for drug development. Recent studies have identified bitter taste receptors (TAS2Rs) in both skin cell lines and human skin. Additionally, bitter natural compounds have shown promising benefits in addressing skin aging, wound healing, inflammatory skin conditions, and even skin cancer. Thus, TAS2Rs may represent a promising target in all these processes. 
  • 143
  • 18 Feb 2024
Topic Review
Deciphering Childhood Rosacea
Rosacea is a chronic inflammatory skin disease that can affect the skin and eyes. The pathogenesis of rosacea is complex and related to interactions between genetic and environmental factors, the dysregulation of innate and acquired immune systems, the dysregulation of nerves and blood vessels, and the imbalance of the skin microbiota, particularly the overgrowth of Demodex mites.
  • 141
  • 26 Feb 2024
Topic Review
Hydrogel-Based Skin Regeneration
The skin is subject to damage from the surrounding environment. The repair of skin wounds can be very challenging due to several factors such as severe injuries, concomitant infections, or comorbidities such as diabetes. Different drugs and wound dressings have been used to treat skin wounds. Tissue engineering, a novel therapeutic approach, revolutionized the treatment and regeneration of challenging tissue damage. Among the various 3D scaffolds used in tissue engineering, hydrogel scaffolds have gained special significance due to their unique properties such as natural mimicry of the extracellular matrix (ECM), moisture retention, porosity, biocompatibility, biodegradability, and biocompatibility properties.
  • 137
  • 27 Feb 2024
Topic Review
Therapeutic Agents Targeting Immune Mediators in Hidradenitis Suppurativa
Hidradenitis suppurativa (HS), also known as acne inversa (AI), is a chronic, recurrent, debilitating skin disease thought to involve occlusion of the hair follicle at the pilosebaceous unit (PSU) such as axillary, inguinal, and anogenital regions. Clinically, HS manifests as painful inflammatory nodules, abscesses, and interconnected tunnels emitting malodorous discharge and results in disfiguring scarring that has a considerable impact on a patient’s quality of life. 
  • 123
  • 07 Feb 2024
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