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Topic Review
Psoriasis and Sport
The link between Psoriasis and sport is a controversial issue. Physical activity has been associated to Pso in a negative way, even if recent studies have highlighted the potential beneficial effect on the natural course of the disease and, as consequence, on patients’ quality of life (QoL).
  • 687
  • 22 Sep 2021
Topic Review
Microbiome Research in Alopecia Areata
The continuous research advances in the microbiome field is changing clinicians’ points of view about the involvement of the microbiome in human health and disease, including autoimmune diseases such as alopecia areata (AA). Both gut and cutaneous dysbiosis have been considered to play roles in alopecia areata. A new approach is currently possible owing also to the use of omic techniques for studying the role of the microbiome in the disease by the deep understanding of microorganisms involved in the dysbiosis as well as of the pathways involved. These findings suggest the possibility to adopt a topical approach using either cosmetics or medical devices, to modulate or control, for example, the growth of overexpressed species using specific bacteriocins or postbiotics or with pH control. This will favour at the same time the growth of beneficial bacteria which, in turn, can impact positively both the structure of the scalp ecosystem on the host’s response to internal and external offenders.
  • 683
  • 08 Jun 2022
Topic Review
Conventional Treatment for Wounds
Application of modern delivery techniques to natural bioactive products improves their permeability, bioavailability, and therapeutic efficacy. Many natural products have desirable biological properties applicable to wound healing but are limited by their inability to cross the stratum corneum to access the wound. Over the past two decades, modern systems such as microneedles, lipid-based vesicles, hydrogels, composite dressings, and responsive formulations have been applied to natural products such as curcumin or aloe vera to improve their delivery and efficacy. 
  • 682
  • 30 May 2022
Topic Review
Linear IgA Disease
Linear IgA disease (LAD) is an autoimmune mucocutaneous disease characterized by linear deposits of IgA at the basement membrane zone on immunopathology. It is also known as linear IgA bullous dermatosis (LABD), but LAD is preferred because it is inclusive of patients without bullous lesions. In the pediatric population, it is known as chronic bullous disease of childhood (CBDC).
  • 679
  • 22 Sep 2021
Topic Review
Animal-Type Melanoma
Animal-type melanoma (ATM) was first described in the literature by Levene in 1979 in relation to a patient with a characteristic clinical presentation, and only later, rare and anecdotal case series have tried to shed light on an entity that has undergone several nosographic classification changes, and which, since 2018, is classified under the term “pigmented epithelioid melanocytoma”. Here, researchers conduct a brief review of the current literature on ATM and present a new clinical case with histopathological, immunophenotypic, and molecular investigations.
  • 677
  • 23 Aug 2021
Topic Review
Work-Related Hand Eczema in Healthcare Workers
Work-related skin diseases are among the most common work-related diseases, ranking second in frequency after musculoskeletal diseases. The majority of work-related skin diseases (80–95%) are contact dermatitis, which can be both irritant and allergic in nature. Lesions are most commonly described as hand eczema and occur as a result of contact with various substances (irritants and allergens) in the workplace. The term “eczema” is generally used to describe a group of skin lesions in which the skin is itchy, dry, and inflamed. However, the term eczema usually involves a non-specific clinical picture but is commonly used in real-life and medical settings when working with patients.
  • 677
  • 07 Oct 2023
Topic Review
Rapid Clinical Management of Leishmaniasis
Leishmaniasis is a vector-born disease caused by a group of protozoan parasites belonging to the genus Leishmania. 
  • 667
  • 04 Nov 2020
Topic Review
Algae Metabolites in Cosmeceutical
Cosmeceuticals are topical cosmetic-pharmaceutical hybrids which refer to a cosmetic product with active ingredients claiming to have medicinal or drug-like benefits to skin health. Marine algae are rich in bioactive substances that have shown to exhibit strong benefits to the skin, particularly in overcoming rashes, pigmentation, aging, and cancer. 
  • 665
  • 29 Mar 2022
Topic Review
Gene Therapy in Dermatology
Gene therapies have not yet been approved to treat skin diseases but the progress in the field has been remarkable over the last couple of decades. For context, China was the first country to approve and commercialize a gene therapy product back in 2003. It was not until 2012 that Glybera became the first gene therapy approved in Europe by the European Medicines Agency (EMA) for the treatment of lipoprotein lipase deficiency, an ultra-rare inherited disorder [33]. Five years later, the United States Food and Drug Administration (FDA) gave approval to Luxturna, ushering in a new range of possibilities for disease treatment. 
  • 659
  • 23 Dec 2021
Topic Review
Trifarotene
Trifarotene is a new fourth-generation retinoid with a selective action on RAR-γ. 
  • 657
  • 22 Sep 2021
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