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Topic Review
The Molecular Hydrogen Hypothesis
Since the late 18th century, molecular hydrogen (H2) has been shown to be well tolerated, firstly in animals, and then in humans. However, although research into the beneficial effects of molecular hydrogen in both plant and mammalian physiology is gaining momentum, the idea of utilising this electrochemically neutral and non-polar diatomic compound for the benefit of health has yet to be widely accepted by regulatory bodies worldwide. Due to the precise mechanisms of H2 activity being as yet undefined, the lack of primary target identification, coupled with difficulties regarding administration methods (e.g., dosage and dosage frequencies, long-term effects of treatment, and the patient’s innate antioxidant profile), there is a requirement for H2 research to evidence how it can reasonably and most effectively be incorporated into medical practice.
  • 455
  • 28 Jan 2022
Topic Review
The Intestinal Microbial Ecosystem
Cardiovascular diseases (CVDs) can refer to several conditions, including hypertension, heart failure, stroke, coronary artery disease, peripheral vascular disease, stroke, rheumatic heart disease, cardiomyopathies, and congenital heart diseases. Globally, CVDs are major contributors to a decreased quality of life and the principal cause of morbidity and mortality. In 2015, 422.7 million cases of CVDs were reported, with 17.92 million deaths due to CVDs.
  • 433
  • 29 Sep 2021
Topic Review
The Immune Response in Primary- and Immunotherapy-Induced Hypophysitis
Hypophysitis is a rare and potentially life-threatening disease, characterized by an elevated risk of complications, such as the occurrence of acute central hypoadrenalism, persistent hypopituitarism, or the extension of the inflammatory process to the neighboring neurological structures. In recent years, a large number of cases has been described. The diagnosis of hypophysitis is complex because it is based on clinical and radiological criteria. Due to this, the integration of molecular and genetic biomarkers can help physicians in the diagnosis of hypophysitis and play a role in predicting disease outcome.
  • 449
  • 12 Nov 2021
Topic Review
The Human Virome
Members of the virome may collaborate with the human host to retain mutualistic functions in preserving human health. Although a person’s virome can alter over time, viral presence in a person can be extremely stable. Since viruses are present in the environment all the time, it is easy to imagine where the members of the changeable virome originate.
  • 347
  • 28 Feb 2023
Topic Review
The Exposome Approach in Allergies and Lung Diseases
Emerging research suggests environmental exposures before conception may adversely affect allergies and lung diseases in future generations. Most studies are limited as they have focused on single exposures, not considering that these diseases have a multifactorial origin in which environmental and lifestyle factors are likely to interact. Traditional exposure assessment methods fail to capture the interactions among environmental exposures and their impact on fundamental biological processes, as well as individual and temporal factors. A valid estimation of exposure preconception is difficult since the human reproductive cycle spans decades and the access to germ cells is limited. The exposome is defined as the cumulative measure of external exposures on an organism (external exposome), and the associated biological responses (endogenous exposome) throughout the lifespan, from conception and onwards. An exposome approach implies a targeted or agnostic analysis of the concurrent and temporal multiple exposures, and may, together with recent technological advances, improve the assessment of the environmental contributors to health and disease. This review describes the current knowledge on preconception environmental exposures as related to respiratory health outcomes in offspring. We discuss the usefulness and feasibility of using an exposome approach in this research, advocating for the preconception exposure window to become included in the exposome concept.
  • 357
  • 17 Dec 2021
Topic Review
Telehealth
The COVID-19 pandemic has led to the implementation of policies that mandate various restrictions on daily life, including social distancing, the closure of public services and schools, and movement limitations. Even though these restrictive measures decreased the COVID-19 spread, they may have detrimental effects on various lifestyle components such as physical inactivity, sedentary behavior, and dietary habits, influencing the maintenance of weight and contributing to obesity among children and adolescents. The coexistence of childhood obesity and COVID-19 and changes in the bioecological environment have put children and adolescents at increased risk for developing obesity and exacerbating the severity of this disorder. The use of telehealth technology is a modern approach useful for the delivery of health care services by health care professionals, where distance is a critical factor. Telehealth is effective in promoting increased self-monitoring and behavioral change, and provides the opportunity to perform online nutritional support and exercise training programs to promote a healthy lifestyle and reduce sedentary behaviors in children and adolescents. Telehealth, including tele-exercise and tele-nutrition, has the potential to address many of the key challenges in providing health services, including in patients with obesity during the COVID-19 outbreak. This narrative review aims to describe the role of telehealth as an opportunity in the management of pediatric obesity in the COVID-19 era, and to deliver nutrition and exercise programs for the maintenance of health  
  • 586
  • 27 Oct 2021
Topic Review
Technologies to Assess COVID-19 Specific Antigens
In diagnosing SARS-CoV-2 infection, the most widely used test is the molecular testing. Real-time reverse transcription polymerase chain reaction (RT-PCR) is the most well-known and extensively used molecular analysis. The test relies on nucleic acid amplification and detects unique sequences of SARS-CoV-2. The other type of test, the antigen tests, can detect the presence of SARS-CoV-2 without amplifying viral components, but these tests are less sensitive than the molecular ones. Commonly, any negative antigen test is confirmed with a molecular test so that the patient can be declared negative for COVID-19. Both molecular and antigen tests would detect patients in the acute phase of infection.
  • 427
  • 21 Dec 2021
Topic Review
Tachyarrhythmias in Congenital Heart Diseases
Major advances in pediatric cardiology in recent decades, especially surgical techniques, have resulted in an increasing number of patients with congenital heart disease (CHD) surviving to adulthood. This has generated new challenges, particularly with regards to the late onset of complex arrhythmias. Abnormal anatomy, surgical scarring, chronic hypoxemia, hemodynamic compromise, neuro-hormonal abnormalities, and genetic factors can all contribute to creating a unique substrate for arrhythmia development.
  • 391
  • 09 Feb 2022
Topic Review
Systemic Bevacizumab for Recurrent Respiratory Papillomatosis
Respiratory recurrent papillomatosis (RRP) is a fatal disease with no known cure. In severe RRP cases, systemic bevacizumab (SB) could be used as adjuvant therapy. SB may be a promissory treatment and control option for RRP. More research is needed to evaluate the efficiency and adverse effects in various populations.
  • 318
  • 09 Feb 2023
Topic Review
Sulfur Compounds in Garlic for Asthma Treatment
Asthma is a chronic inflammatory disease in the airways with a multifactorial origin but with inflammation and oxidative stress as related pathogenic mechanisms. Garlic (Allium sativum) is a nutraceutical with different biological properties due to sulfur-containing natural compounds. Studies have shown that several compounds in garlic may have beneficial effects on cardiovascular diseases, including those related to the lungs. Therefore, it is possible to take advantage of the compounds from garlic as nutraceuticals for treating lung diseases.
  • 878
  • 14 Dec 2022
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