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Topic Review
Application of Membrane Technology in the Pharmaceutical Industry
With the advancement in membrane technology, membrane separation technology has been found increasingly widespread applications in the pharmaceutical industry. It is utilized in drug separation and purification, wastewater treatment, and the recycling of wastewater resources. 
  • 278
  • 23 Jan 2024
Topic Review
Application of mRNA Technology in Cancer Therapeutics
mRNA-based therapeutics pose as promising treatment strategies for cancer immunotherapy. Improvements in materials and technology of delivery systems have helped to overcome major obstacles in generating a sufficient immune response required to fight a specific type of cancer. Several in vivo models and early clinical studies have suggested that various mRNA treatment platforms can induce cancer-specific cytolytic activity, leading to numerous clinical trials to determine the optimal method of combinations and sequencing with already established agents in cancer treatment.
  • 422
  • 02 Sep 2022
Topic Review
Application of Nanoparticles in Immunotherapy
Natural killer（NK） cells are a part of the native immune response to cancer. NK cell-based immunotherapies are an emerging strategy to kill tumor cells. 
  • 686
  • 18 Nov 2022
Topic Review
Application of Nanotechnologies in Ischemic Heart Disease
Nanotechnology focuses on atomic and molecular structures with dimensions of 0.1–100 nm. The resulting nanomaterials exhibit distinct mechanical, electrical, thermal, magnetic and imaging features that facilitate novel and unique applications in different branches of science, such as nanomedicine, nanobiology and nanobiotechnology.
  • 532
  • 09 Nov 2021
Topic Review
Application of Photodynamic Therapy in Bone Cancer
Bone cancer including primary bone cancer and metastatic bone cancer, remains a challenge claiming millions of lives and affecting the life quality of survivors. Conventional treatments of bone cancer include wide surgical resection, radiotherapy, and chemotherapy. However, some bone cancer cells may remain or recur in the local area after resection, some are highly resistant to chemotherapy, and some are insensitive to radiotherapy. Photodynamic therapy (PDT) is a clinically approved, minimally invasive, and highly selective treatment, and has been widely reported for cancer therapy. Under the irradiation of light of a specific wavelength, the photosensitizer (PS) in PDT can cause the increase of intracellular ROS leading to the tumoricidal effects. In this review, the progress of PDT applications in the treatment of bone cancer has been outlined and summarized, and some envisioned challenges and future perspectives have been mentioned. This review provides the current state of the art regarding PDT in bone cancer and inspiration for future studies on PDT.
  • 496
  • 17 Nov 2021
Topic Review
Application of Plasma Proteome Signature in Breast Cancer
The prognostic impact of plasma protein biomarkers in breast cancer patients treated with neoadjuvant chemotherapy (NCT) was evaluated using a proteomics approach. Three biomarkers were identified among differentially expressed proteins. The plasma concentration of APOC3 was higher in the pathological complete response (pCR) group, whereas MBL2, ENG, and P4HB were upregulated in the non-pCR group.
  • 581
  • 28 Dec 2021
Topic Review
Application of Polyphenols in Cancer Therapy
The characteristics of polyphenols in modulating redox homeostasis have been widely applied in cancer prevention and treatment, which lays the basis for the discovery and development of natural anticancer drugs. Indeed, many polyphenols have been explored in preclinical or clinical trials, but the drawbacks of polyphenols generally disturb their versatile properties in clinical settings
  • 836
  • 17 Jan 2023
Topic Review
Application of Probiotics for Acne Vulgaris Topical Therapies
The skin microbiome is an essential barrier for preventing the invasion of pathogens and regulating the immune responses. When this barrier is disrupted, several dermatoses, including acne vulgaris, may arise. Probiotics have proven to be an alternative to the use of antibiotics, often associated with undesirable effects, in the treatment and prevention of dermatological disorders such as acne. 
  • 368
  • 30 May 2023
Topic Review
Application of Proteomics in Giardia duodenalis
Giardia duodenalis remains a neglected tropical disease. A key feature of the sustained transmission of Giardia is the ability to form environmentally resistant cysts. Valuable information from proteomics analyses of G. duodenalis has been discovered in terms of the pathogenesis and virulence of Giardia, which may provide guidance for the development of better means with which to prevent and reduce the impacts of giardiasis.
  • 503
  • 18 Nov 2022
Topic Review
Application of Proteomics in Optic Nerve Injury Diseases
Optic nerve damage is a common cause of blindness. Optic nerve injury is often accompanied by fundus vascular disease, retinal ganglion cell apoptosis, and changes in retinal thickness. These changes can cause alterations in protein expression within neurons in the retina. Proteomics analysis offers conclusive evidence to decode a biological system. Optic nerve damage can significantly reduce the vision of patients, thereby having a serious impact on their daily lives and their families. In clinical practice, optic nerve injury is mainly diagnosed by optical tomography (OCT) detection and by fundus angiography. 
  • 324
  • 12 Apr 2023
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