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Topic Review
Anticancer Activity of Pentagalloyl Glucose
Pentagalloyl glucose (PGG) is a natural hydrolyzable gallotannin abundant in various plants and herbs. It has a broad range of biological activities, specifically anticancer activities, and numerous molecular targets. PGG has a cytotoxic effect on many cancers, including prostate, breast, lung, head and neck, liver, leukemia, cervical, colorectal, and pancreatic cancers. PGG can affect different cancer stages and inhibit tumor growth through multiple mechanisms depending on cell origin, with minimal toxicity against normal cells. PGG targets several aberrant signal-transduction pathways that control cell growth and division, apoptosis, angiogenesis, and metastasis.
  • 306
  • 07 Jul 2023
Topic Review
Anticancer Activity of Propolis
Propolis is a natural material that honey bees (Apis mellifera) produce from various botanical sources. The therapeutic activity of propolis, including antibacterial, antifungal, and anti-inflammatory effects, have been known since antiquity. Propolis is a rich source of biologically active compounds, which affect numerous signaling pathways regulating crucial cellular processes. The results of the latest research show that propolis can inhibit proliferation, angiogenesis, and metastasis of cancer cells and stimulate apoptosis. Moreover, it may influence the tumor microenvironment and multidrug resistance of cancers.
  • 1.5K
  • 12 Aug 2021
Topic Review
Anticancer Activity of Trichostatin A
Trichostatin A (TSA), a natural derivative of dienohydroxamic acid derived from a fungal metabolite, exhibits various biological activities. It exerts antidiabetic activity and reverses high glucose levels caused by the downregulation of brain-derived neurotrophic factor (BDNF) expression in Schwann cells, anti-inflammatory activity by suppressing the expression of various cytokines, and significant antioxidant activity by suppressing oxidative stress through multiple mechanisms. Most importantly, TSA exhibits potent inhibitory activity against different types of cancer through different pathways. The anticancer activity of TSA appeared in many in vitro and in vivo investigations that involved various cell lines and animal models.
  • 428
  • 31 Oct 2022
Topic Review
Anticancer Drug-Induced Cardiotoxicity
The advancement in therapy has provided a dramatic improvement in the rate of recovery among cancer patients. However, this improved survival is also associated with enhanced risks for cardiovascular manifestations, including hypertension, arrhythmias, and heart failure. The cardiotoxicity induced by chemotherapy is a life-threatening consequence that restricts the use of several chemotherapy drugs in clinical practice. 
  • 899
  • 28 Sep 2021
Topic Review
Anticancer Drugs and Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a rare progressive motor neuron disease that, due to its high complexity, still lacks effective treatments. Development of a new drug is a highly costly and time-consuming process, and the repositioning of approved drugs can represent an efficient strategy to provide therapeutic opportunities. This is particularly true for rare diseases, which are characterised by small patient populations and therefore attract little commercial interest. Based on the overlap between the biological background of cancer and neurodegeneration, the repurposing of antineoplastic drugs for ALS has been suggested.
  • 215
  • 21 Feb 2024
Topic Review
Anticancer Effects of Selenium Compounds
The chemistry of selenium (Se) compounds is not a young field, since its beginning was in the first half of the 19th century. The first steps in this scope were initiated in 1836 by the then toxicologists, who discovered a Se metabolite, diethyl selenide, excreted by inhalation during research using inorganic selenium compounds on animals. Meanwhile, the first synthesis of selenium-containing (Se-containing) compounds took place in 1847, when ethylselenol was obtained. Since then, selenium chemistry has developed greatly and investigators have started to look at whether it can help with society’s health problems, including cancer. The high number of new cancer incidences and the associated mortality continue to be alarming, leading to the search for new therapies that would be more effective and less burdensome for patients. As there is evidence that Se compounds can have chemopreventive activity, studies have begun to establish whether these compounds can also affect already existing cancers. This review aims to discuss the different classes of Se-containing compounds, both organic and inorganic, natural and synthetic, and the mechanisms and molecular targets of their anticancer activity.
  • 796
  • 10 May 2021
Topic Review
Anticancer Effects of α-Linolenic Acid
α-linolenic acid (ALA) belongs to the family of n-3 polyunsaturated fatty acids (n-3 PUFAs) and contains a carbon–carbon double bond on the third carbon atom at the methyl end of the carbon chain. This family of essential fatty acids also includes eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). ALA has gradually attracted increased attention due to its nutritional and medicinal advantages. Studies have shown that ALA exerts beneficial effects on a variety of diseases, including cancer.
  • 196
  • 19 Mar 2024
Topic Review
Anticancer Nanotherapeutics in Clinical Trials
The ultimate goal of nanomedicine has always been the generation of translational technologies that can ameliorate current therapies. Cancer disease represented the primary target of nanotechnology applied to medicine, since its clinical management is characterized by very toxic therapeutics. In this effort, nanomedicine showed the potential to improve the targeting of different drugs by improving their pharmacokinetics properties and to provide the means to generate new concepts of treatments based on physical treatments and biologics.
  • 686
  • 10 Nov 2022
Topic Review
Anticancer Oximes
Among the indole-based oximes and oxime ethers, derivatives of indirubin (5) have been extensively investigated for their anticancer activity.
  • 305
  • 23 Feb 2024
Topic Review
Anticancer Phytochemicals and Their Structure
Cancer is a challenging disease and is the main cause of mortality worldwide; however, its impact is not evenly distributed. The cancer burden in developed and underdeveloped countries has increased over time owing to a variety of factors, including aging and growing populations, rapid socioeconomic growth, and changes in the incidence of risk factors. Since ancient times, plant-based medicines have been employed in clinical practice and have yielded good results. The modern research system and advanced screening techniques for plants’ bioactive constituents have enabled phytochemical discovery for the prevention and treatment of challenging diseases such as cancer. 
  • 643
  • 30 May 2022
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