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All Topic Review Biography
Topic Review
Ankle and Foot Arthroplasty and Prosthesis
The foot and ankle serve vital roles in weight bearing, balance, and flexibility but are susceptible to many diverse ailments, making treatment difficult. More commonly, Total Ankle Arthroplasty (TAA) and Total Talus Replacement (TTR) are used for patients with ankle degeneration and avascular necrosis of the talus, respectively. Ankle prosthesis and orthosis are also indicated for use with lower limb extremity amputations or locomotor disability, leading to the development of powered exoskeletons. However, patient outcomes remain suboptimal, commonly due to the misfitting of implants to the patient-specific anatomy. Additive manufacturing (AM) is being used to create customized, patient-specific implants and porous implant cages that provide structural support while allowing for increased bony ingrowth and to develop customized, lightweight exoskeletons with multifunctional actuators. AM implants and devices have shown success in preserving stability and mobility of the joint and achieving fast recovery, as well as significant improvements in gait rehabilitation, gait assistance, and strength for patients. 
  • 293
  • 20 Nov 2023
Topic Review
Ankle Arthropathy in Hereditary Hemochromatosis
Hereditary hemochromatosis (HH) is an autosomal recessive bleeding disorder characterized by tissue overload of iron. Clinical systemic manifestations in HH include liver disease, cardiomyopathy, skin pigmentation, diabetes mellitus, erectile dysfunction, hypothyroidism, and arthropathy. Arthropathy with joint pain is frequently reported at diagnosis and mainly involves the metacarpophalangeal and ankle joints, and more rarely, the hip and knee. Symptoms in ankle joints are in most cases non-specific, and they can range from pain and swelling of the ankle to deformities and joint destruction. Furthermore, the main radiological signs do not differ from those of primary osteoarthritis (OA). Limited data are available in the literature regarding treatment; surgery seems to be the gold standard for ankle arthropathy in HH. 
  • 230
  • 21 Sep 2023
Topic Review
Ankyrin/Spectrin in Cardiac Conduction
The cardiac conduction system is an extended network of excitable tissue tasked with generation and propagation of electrical impulses to signal coordinated contraction of the heart. The fidelity of this system depends on the proper spatio-temporal regulation of ion channels in myocytes throughout the conduction system. Importantly, inherited or acquired defects in a wide class of ion channels has been linked to dysfunction at various stages of the conduction system resulting in life-threatening cardiac arrhythmia. Members of the ankyrin and spectrin families have emerged as important nodes for normal expression and regulation of ion channels in myocytes throughout the conduction system. Human variants impacting ankyrin/spectrin function give rise to a broad constellation of cardiac arrhythmias. Furthermore, chronic neurohumoral and biomechanical stress promotes ankyrin/spectrin loss of function that likely contributes to conduction disturbances in the setting of acquired cardiac disease.
  • 577
  • 12 May 2021
Topic Review
Annular Erythemas and Purpuras
Annular dermatoses (AD) are a heterogeneous group of skin diseases, whose common feature is essentially the annular or circular arrangement of the lesions with centrifugal spreading. They belong to the group of figurate dermatoses, to which can be added linear or serpiginous dermatoses, for example. They are a fascinating curiosity for the dermatologist, as they form patterns and arabesques on the patient’s body.
  • 1.9K
  • 01 Jun 2023
Topic Review
Anorgasmia
Anorgasmia is a type of sexual dysfunction in which a person cannot achieve orgasm despite adequate stimulation. Anorgasmia is far more common in females (4.6 percent) than in males and is especially rare in younger men. The problem is greater in women who are post-menopause. In males, it is most closely associated with delayed ejaculation. Anorgasmia can often cause sexual frustration.
  • 687
  • 07 Nov 2022
Topic Review
Antenatal Depression
Antenatal depression, also known as prenatal or perinatal depression, is a form of clinical depression that can affect a woman during pregnancy, and can be a precursor to postpartum depression if not properly treated. It is estimated that 7% to 20% of pregnant women are affected by this condition. Any form of prenatal stress felt by the mother can have negative effects on various aspects of fetal development, which can cause harm to the mother and child. Even after birth, a child born from a depressed or stressed mother feels the affects. The child is less active and can also suffer from emotional distress. Antenatal depression can be caused by the stress and worry that pregnancy can bring, but at a more severe level. Other triggers include unplanned pregnancy, difficulty becoming pregnant, history of abuse, and economic or family situations. Commonly, symptoms involve how the patient views herself, how she feels about going through such a life changing event, the restrictions on the mother's lifestyle that motherhood will place, or how the partner or family feel about the baby. Pregnancy places significant strain on a woman's body, so stress, mood swings, sadness, irritability, pain, and memory changes are to be expected. Left untreated, antenatal depression can be extremely dangerous for the health of the mother and the baby. It is highly recommended that mothers who feel they are experiencing antenatal depression have a discussion about it with their health care provider. Mothers with a history of mental health issues should also talk to their doctor about it early in the pregnancy to help with possible depressive symptoms.
  • 337
  • 28 Nov 2022
Topic Review
Anterior Chamber Angle Assessment Techniques
This review summarizes the last findings in Anterior Chamber Angle evaluation, focusing on new instruments and their application to the clinical practice. Special attention will be given to the comparison between these new techniques and traditional slit-lamp gonioscopy.
  • 1.5K
  • 11 Dec 2020
Topic Review
Anterior Open Bite Treatment with Skeletal Anchorage
Anterior open bite (AOB) is still one of the most difficult and demanding clinical problems. This malocclusion relies on a reduction in the vertical relationship between the incisal edges of the upper and lower incisors.
  • 750
  • 29 Dec 2021
Topic Review
Anterior Skull Base Reconstruction Using the Nasoseptal Flap
The nasoseptal flap (NSF) has become a workhorse reconstructive option in the endonasal repair of anterior skull base defects. The flap is pedicled on the posterior septal nasal artery, which branches off the sphenopalatine artery and courses along the posterior nasal cavity and inferior sphenoid face. Due to its versatile nature and customizability, the NSF can be utilized for a range of different defects extending from the frontal recess to the low clivus in the sagittal plane. 
  • 245
  • 11 Jan 2024
Topic Review
Anterior-Segment Optical-Coherence Tomography
Anterior-segment optical-coherence tomography (AS-OCT) is used to assess the iridocorneal angle and its alterations. The introduction of AS-OCT has led to improved assessments of the anatomy of the iridocorneal-angle and diagnoses of several mechanisms of angle closure which often result in raised intraocular pressure (IOP). Continuous advancements in AS-OCT technology and software, along with an extensive research in the field, have resulted in a wide range of possible parameters that may be used to diagnose and follow up on patients with this spectrum of diseases. However, the clinical relevance of such variables needs to be explored thoroughly.
  • 974
  • 14 Feb 2021
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