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Topic Review
Glass Ionomer Cement
The glass ionomer cement (GIC) is a translucent, water-based cement invented in 1972 by Wilson and Kent.
  • 1.8K
  • 30 Nov 2021
Topic Review
Antibiotic Resistance
Antibiotics are defined as natural or synthetic chemicals inhibiting both the growth and survival of microorganisms. These compounds have been used as essential therapeutics for nearly a century. With the human population growth increasingly, antibiotics become preventive agents in the agricultural and animal industry. The multi-faceted global use and misuse of antibiotics led to the evolution of bacteria into antibiotic resistant species. Advantageous mutations cause antibiotic tolerance, which is transmitted to offspring (vertical evolution) or to another bacteria via conjugation, transduction, or transformation mode (horizontal evolution), that are then are then passed down to progeny (vertical evolution). Antibiotic resistance progressively increased mortality from multidrug-resistant bacterial infections, threatening public health. Probiotics, essential oils, vaccines, and antibodies to antibiotic resistant bacteria emerge as primary or adjunct preventive measures or therapies against multidrug-resistant bacterial infections. Bacteriophages and predatory bacteria, as well as utilization of bacterial communication quorum sensing considered as new ecosystem-influenced methods to tackle multidrug-resistant bacteria. Mechanisms of dissemination and the development of antibiotic resistance genes vary in the context of nutrition and related clinical, agricultural, veterinary, and environmental settings, this need to be accounted in selections of preventive and therapeutic countermeasures. 
  • 1.8K
  • 05 Feb 2022
Topic Review
Timeline of Malaria
Malaria is an infectious disease caused by a parasite; it is spread by the bite of an infected mosquito. Every year, 300 to 700 million people get infected. Malaria kills 1 million to 2 million people every year. 90% of the deaths occur in Africa.
  • 1.8K
  • 31 Oct 2022
Topic Review
Chitosan-Nanoparticles for Oral Insulin Delivery
Diabetes mellitus is a chronic endocrine disease, affecting more than 400 million people around the world. Patients with poorly controlled blood glucose levels are liable to suffer from life-threatening complications, such as cardiovascular, neuropathy, retinopathy and even premature death. Today, subcutaneous parenteral is still the most common route for insulin therapy. Oral insulin administration is favourable and convenient to the patients. In contrast to injection route, oral insulin delivery mimics the physiological pathway of endogenous insulin secretion. However, oral insulin has poor bioavailability (less than 2%) due to the harsh physiological environment through the gastrointestinal tract (GIT). Over the last few decades, many attempts have been made to achieve an effective oral insulin formulation with high bioavailability using insulin encapsulation into nanoparticles as advanced technology. Various natural polymers have been employed to fabricate nanoparticles as a delivery vehicle for insulin oral administration. Chitosan, a natural polymer, is extensively studied due to the attractive properties, such as biodegradability, biocompatibility, bioactivity, nontoxicity and polycationic nature. Numerous studies were conducted to evaluate chitosan and chitosan derivatives-based nanoparticles capabilities for oral insulin delivery. This review highlights strategies that have been applied in the recent five years to fabricate chitosan/chitosan derivatives-based nanoparticles for oral insulin delivery. A summary of the barriers hurdle insulin absorption rendering its low bioavailability such as physical, chemical and enzymatic barriers are highlighted with an emphasis on the most common methods of chitosan nanoparticles preparation. Nanocarriers are able to improve the absorption of insulin through GIT, deliver insulin to the blood circulation and lower blood glucose levels. In spite of some drawbacks encountered in this technology, chitosan and chitosan derivatives-based nanoparticles are greatly promising entities for oral insulin delivery.
  • 1.8K
  • 02 Nov 2020
Topic Review
Senotherapy
During aging, many biological processes are altered, which globally induce the dysfunction of the whole organism. Cell senescence is one of the causes of this modification. Nowadays, several drugs approved for anticancer therapy have been repurposed to treat senescence, and others are under scrutiny in vitro and in vivo. In particular, molecules named “senomorphics” have been used to prevent or to slow down aging; meanwhile ,those that have been recently identified to induce apoptosis in senescent cells, reducing their number, are called "senolytics”
  • 1.8K
  • 17 Nov 2020
Topic Review
Silphium
The chemical composition of three Silphium species in the aspect of the possibility of their use for various purposes has been evaluated. The plant material of three Silphium species (S. perfoliatum, S. trifoliatum and S. integrifolium) was acquired from cultivation located in eastern Poland. The vegetative propagating material consisted of seeds and rhizomes. Content of protein (up to 22.9% in leaves of S. perfoliatum), amino acids (aspartic acid—up to 12.0%, glutamic acid—up to 9.5%, and leucine—up to 9.4%), fat (up to 4.2% in inflorescences of S. perfoliatum), cellulose (up to 42.9% in stems of S. trifoliatum), water-soluble sugars (up to 26.7% in rhizomes of S. perfoliatum) and mineral substances (ash up to 20.9% in stems of S. integrifolium, with significant levels of elements such as K, Ca, Mg, Fe, Mn) in the tested Silphium species can be an important criterion determining a positive evaluation of these plants as sources of alternative raw materials. The conducted research is meant to draw attention to the possibility of use of the biomass of three Silphium species as a potential source of ecological and renewable raw material for food, pharmaceuticals, feed and possibly also for energy generation purposes.
  • 1.8K
  • 02 Nov 2020
Topic Review
Dissociation (Neuropsychology)
In neuropsychology, dissociation involves identifying the neural substrate of a particular brain function through identification of case studies, neuroimaging, or neuropsychological testing.
  • 1.8K
  • 23 Nov 2022
Topic Review
Glutathione and Cardiovascular Diseases
Cardiovascular diseases such as coronary artery occlusion, hypertensive heart disease and stroke, high blood pressure, myocardial infarction, cerebrovascular disease, heart failure, rheumatic heart disease, congenital heart disease and cardiomyopathies generate thousands of patients with high mortality and morbidity worldwide. The appearance of these diseases increases with the aging of the population. In addition, these diseases are complicated by some comorbidity that patients present (overweight, obesity, diabetes mellitus, etc.). The installation and development of these diseases are closely linked to metabolic changes that generate a state of oxidative stress, due to the excessive production of reactive oxygen species (ROS) and reactive nitrogen species (RNS).
  • 1.8K
  • 09 Aug 2021
Topic Review
(Endo)Cannabinoids and Gynaecological Cancers
Gynaecological cancers can be primary neoplasms, originating either from the reproductive tract or the products of conception, or secondary neoplasms, representative of metastatic disease. For some of these cancers, the exact causes are unknown; however, it is recognised that the precise aetiopathogeneses for most are multifactorial and include exogenous (such as diet) and endogenous factors (such as genetic predisposition), which mutually interact in a complex manner. One factor that has been recognised to be involved in the pathogenesis and progression of gynaecological cancers is the endocannabinoid system (ECS). The ECS consists of endocannabinoids (bioactive lipids), their receptors, and metabolic enzymes responsible for their synthesis and degradation.
  • 1.8K
  • 31 Aug 2021
Topic Review
Biosurfactants Properties
Biosurfactants (BSs) are emerging surface-active molecules with high potential for a wide range of applications in the biomedical and pharmaceutical fields. BSs are extremely attractive due to their significant antimicrobial (against bacteria, fungi and viruses), antiadhesive and biofilm disruptive properties. Their use, either on their own or in combination with other antimicrobial or chemotherapeutic drugs, might pave the way for a future strategy of prevention and counteraction of microbial infections, biofilm formation and proliferation. In addition, BSs have recently attracted the attention of the scientific community as a new potential generation of pharmaceutics to be included in anticancer, immunomodulatory, wound healing, cosmetic and drug delivery agents.
  • 1.8K
  • 11 May 2021
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