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Topic Review
Therapeutic Implications of Tumour Microenvironment
The tumour microenvironment (TME) comprises a complex ecosystem of different cell types, including immune cells, cells of the vasculature and lymphatic system, cancer-associated fibroblasts, pericytes, and adipocytes. Cancer proliferation, invasion, metastasis, drug resistance and immune escape are all influenced by the dynamic interaction between cancer cells and TME. Microbes, such as bacteria, fungi, viruses, archaea and protists, found within tumour tissues, constitute the intratumour microbiota, which is tumour type-specific and distinct among patients with different clinical outcomes. Growing evidence reveals a significant relevance of local microbiota in the colon, liver, breast, lung, oral cavity and pancreas carcinogenesis. Moreover, there is a growing interest in the tumour immune microenvironment (TIME) pointed out in several cross-sectional studies on the correlation between microbiota and TME. It is now known that microorganisms have the capacity to change the density and function of anticancer and suppressive immune cells, enabling the promotion of an inflammatory environment. As immunotherapy (such as immune checkpoint inhibitors) is becoming a promising therapy using TIME as a therapeutic target, the analysis and comprehension of local microbiota and its modulating strategies can help improve cancer treatments. 
  • 2.1K
  • 22 Aug 2022
Topic Review
Phenolic Antioxidants and Human Health
Consumers increasingly prefer and seek food and beverages, which, due to their natural characteristics, bring health benefits, both in the prevention of diseases and in their curative power. In this way, the production of nutraceutical foods and beverages gains more and more importance in the market. On the other hand, and because the eyes also eat, producing attractive foods due to their color, texture, appearance, and sensory characteristics is a permanent challenge in the food industry. Being able to gather healthy and attractive items in a single food is an even greater challenge. The long list of benefits associated with phenolic compounds, such as antioxidant, anticancer, anti-inflammatory, and antiaging properties, among others, fully justifies their use in the enrichment of various food products. 
  • 2.1K
  • 14 Mar 2021
Topic Review
Gingival Crevicular Fluid
The Gingival Crevicular Fluid (GCF) consists of various host and bacterial-derived products as well as biomarkers which in turn can be evaluated for the diagnosis, prognosis as well as management of the periodontal disease. 
  • 2.1K
  • 23 Apr 2021
Topic Review
Digital Anthropometry for Body Circumference Measurements
Anthropometry is the study of the measurements and proportions of the human body. Weight, stature (standing height), length (e.g., limb lengths), skinfold thickness, breadth (e.g., shoulder, wrist, etc.), and circumference are examples of anthropometric measures widely adopted in daily medical practice for monitoring growth and aging as well as for the clinical management of patients.
  • 2.1K
  • 08 Jun 2022
Topic Review
Born Equal: Can Genetics Make the Perfect Athlete?
Thanks to the dawn of accessible science to map the human genome and the research that is poured into it, genetics are playing a larger role in elite sports. Genetics have a large influence over many attributes necessary for athletic excellence such as strength, muscle size, muscle fibre composition, anaerobic threshold, lung capacity, and flexibility. The aim of the study was to analyse a large database of athletes, comparing their chosen sports and the level that they play. Analysis of the individuals will include genotypes in six heavily studied genes attributed to athlete potential: ACTN3, MSTN, NOS3, ACE, AMPD1 and TRHR. A combination of both nurture and nature will always be required to bring the most out of an individual, however it would be naïve to ignore natural gifts. Genotypes may give an advantage to certain individuals but the lines between which genotype bring the most benefits is blurred, certain genotypes such as those found in MSTN are very uncommon but have very high affinity for power sports and bodybuilding. Other genes such as the once hailed “sports gene” ACTN3 have far more varied distribution and no particular athlete appeared to be hampered from any genotype, however the C allele did have affinity towards strength and power. From the six analysed genes in the study both power/strength athletes and bodybuilders had completed genotype affinity, however these genes seem to have less impact on those that compete in endurance/stamina sports. The  ACTN3 C allele, MSTN G allele, NOS3 T allele, ACE II, AMPD1 C allele and TRHR C allele all show affinity towards power, strength and/or bodybuilding athletes, only the NOS3 C allele showed a true affinity towards endurance/stamina sports. 
  • 2.1K
  • 13 Aug 2022
Topic Review
Notch Signaling Function in Angiogenesis
The Notch signaling pathway is a major regulator of vascular morphogenesis, managing endothelial response to vascular growth factors, endothelial specialization, establishment and maintenance of vascular identity as venous or arterial and vascular maturation.
  • 2.1K
  • 03 Dec 2020
Topic Review
Breast Implant Illness
Breast implant illness refers to a combination of different symptoms related to breast implant surgery, including fatigue, brain fog, and arthralgias. This malaise occurs after cosmetic and reconstructive breast surgeries, although it has not been proven to be a disease. Complications associated with breast implants include breast pain, capsular contracture, infections, as well as other manifestations specific to breast reconstruction. 
  • 2.1K
  • 26 May 2022
Topic Review
Transtheoretical Model
The transtheoretical model of behavior change is an integrative theory of therapy that assesses an individual's readiness to act on a new healthier behavior, and provides strategies, or processes of change to guide the individual. The model is composed of constructs such as: stages of change, processes of change, levels of change, self-efficacy, and decisional balance. The transtheoretical model is also known by the abbreviation "TTM" and sometimes by the term "stages of change", although this latter term is a synecdoche since the stages of change are only one part of the model along with processes of change, levels of change, etc. Several self-help books—Changing for Good (1994), Changeology (2012), and Changing to Thrive (2016)—and articles in the news media have discussed the model. It has been called "arguably the dominant model of health behaviour change, having received unprecedented research attention, yet it has simultaneously attracted criticism".
  • 2.1K
  • 21 Oct 2022
Topic Review
Theranostics
“Theranostics,” a new concept of medical advances featuring a fusion of therapeutic and diagnostic systems, provides promising prospects in personalized medicine, especially cancer. 
  • 2.1K
  • 27 Apr 2021
Topic Review
Nanomaterials Combined with Bacteriocins
Bacteriocins are antimicrobial peptides or proteinaceous materials produced by bacteria against pathogens. These molecules have high efficiency and specificity and are equipped with many properties useful in food-related applications, such as food preservatives and additives, as well as biomedical applications, such as serving as alternatives to current antibacterial, antiviral, anti-cancer, and antibiofilm agents. Despite their advantages as alternative therapeutics over existing strategies, several limitations of bacteriocins, such as the high cost of isolation and purification, narrow spectrum of activity, low stability and solubility, and easy enzymatic degradation, need to be improved. Nanomaterials are promising agents in many biological applications. They are widely used in the conjugation or decoration of bacteriocins to augment the activity of bacterioc-ins or reduce problems related to their use in biomedical applications. Therefore, bacteriocins combined with nanomaterials have emerged as promising molecules that can be used in various biomedical applications.
  • 2.1K
  • 11 Oct 2021
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