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Topic Review
Excipients Used for Modified Nasal Drug Delivery
Intranasal absorption is a favored route because it avoids the gastrointestinal and hepatic metabolism, leading to an increase in drug bioavailability, and a reduction in the side effects and the required dose administered. The ongoing challenging task in the field of nasal drug delivery is the maintenance of an efficient concentration of the active substance in the target area for an adequate period of time. 
  • 1.0K
  • 27 Sep 2022
Topic Review
Comparison of Different Types of Palatal Expanders
Maxillary bone contraction is caused by genetics or ambiental factors and is often accompanied by dental crowding, with the possibility of canine inclusion, crossbite, class II and III malocclusion, temporomandibular joint disorder, and obstructive sleep apnea (OSAS). Transverse maxillary deficits, in which the maxillary growth is unusually modest, are frequently treated with maxillary expansion. The purpose herein is to compare the dental and skeletal effects of different types of expanders, particularly the Leaf Expander, rapid and slow dental-anchored or skeletal-anchored maxillary expanders. 
  • 1.0K
  • 04 Aug 2023
Topic Review
Cisplatin-Induced Kidney Injury
Cisplatin is a chemotherapy agent commonly used to treat a wide variety of cancers. Despite the potential for both severe acute and chronic side effects, it remains a preferred therapeutic option for many malignancies due to its potent anti-tumor activity. Common cisplatin-associated side-effects include acute kidney injury (AKI) and chronic kidney disease (CKD). These renal injuries may cause delays and potentially cessation of cisplatin therapy and have long-term effects on renal function reserve. Thus, developing mechanism-based interventional strategies that minimize cisplatin-associated kidney injury without reducing efficacy would be of great benefit. In addition to its action of cross-linking DNA, cisplatin has been shown to affect mitochondrial metabolism, resulting in mitochondrially derived reactive oxygen species (ROS). Increased ROS formation in renal proximal convoluted tubule cells is associated with cisplatin-induced AKI and CKD.
  • 1.0K
  • 11 Nov 2021
Topic Review
Promising Lead Compounds for Resistant-Tuberculosis
According to WHO report, globally about 10 million active tuberculosis cases, resulting in about 1.6 million deaths, further aggravated by drug-resistant tuberculosis and/or comorbidities. Incomplete therapeutic regimen, meager dosing, and the capability of the latent and/or active state tubercular bacilli to abide and do survive against contemporary first-line and second-line antitubercular drugs escalate the prevalence of drug-resistant tuberculosis. To explore and identify the most potential antitubercular drug candidate among various reported compounds, here we focused to highlight the promising lead derivatives of isoniazid, coumarin, griselimycin, and antimicrobial peptides. The aim of the present review is to fascinate significant lead compounds in the development of potential clinical drug candidates that might be more precise and effective against drug-resistant tuberculosis, the world research looking for a long time.
  • 1.0K
  • 10 Dec 2020
Topic Review
P-Glycoprotein Inhibitors
P-gp inhibitors are compounds that block or bypass P-gp efflux. The concurrent administration of P-gp inhibitors with P-gp substrates can prevent the expulsion of these substrates and increase their therapeutic effects. Researchers have identified, studied, and evaluated various P-gp inhibitors, including small molecules, natural products, and pharmaceutically inert excipients.
  • 1.0K
  • 18 Aug 2021
Topic Review
Tolerogenic Vaccines to Induce Antigen-Specific Tolerance
Conventional therapies for immune-mediated diseases, including autoimmune disorders, transplant reactions, and allergies, have undergone a radical evolution in the last few decades; however, they are still not specific enough to avoid widespread immunosuppression. The idea that vaccine usage could be extended beyond its traditional immunogenic function by encompassing the ability of vaccines to induce antigen-specific tolerance may revolutionize preventive and therapeutic strategies in several clinical fields that deal with immune-mediated disorders. 
  • 1.0K
  • 22 Sep 2022
Topic Review
Artificial Intelligence in Translational Medicine
Between preclinical and clinical research, translational research is benefitting from computer-based approaches like Artificial Intelligence, resulting in breakthroughs for advancing human health. 
  • 1.0K
  • 17 Dec 2021
Topic Review
Prognosis in Pre-Fibrotic Primary Myelofibrosis
The 2016 WHO classification recognized pre-fibrotic primary myelofibrosis (pre-PMF) as a distinct entity. Nevertheless, a prognostic model specific for pre-PMF is still lacking. 
  • 1.0K
  • 08 Apr 2022
Topic Review
DYRK kinase family in cancer
       DYRK (dual-specificity tyrosine-regulated kinases) are an evolutionary conserved family of protein kinases with members from yeast to humans. In humans, DYRKs are pleiotropic factors that phosphorylate a broad set of proteins involved in many different cellular processes, including those associated with all the hallmarks of cancer. In accordance with an involvement of DYRK kinases in the regulation of tumorigenic processes, an increasing number of research studies are showing either alterations of DYRK gene expression in tumor samples and/or providing evidence of DYRK-dependent mechanisms that contribute to tumor initiation and/or progression.
  • 1.0K
  • 28 Aug 2020
Topic Review
Bioactive Phytochemicals
Bioactive phytochemicals, including natural compounds, secondary metabolites and their derivatives, have attracted significant attention for use in both medicinal products and cosmetic products. Our review highlights the pharmacological mode-of-action and current biomedical applications of key bioactive compounds applied as anti-inflammatory, bactericidal with antibiotics effects, and pain relief purposes in controlled clinical studies or preclinical studies.
  • 1.0K
  • 09 Jun 2021
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