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Topic Review
Food Allergen Immunotherapy for IgE-Mediated Food Allergy Treatment
Implementation of an elimination diet is not a sufficient therapeutic strategy in patients with food allergy, whose quality of life is significantly impaired. In recent years, new effective therapeutic strategies have been developed, such as the application of oral, sublingual, and epicutaneous immunotherapy. Oral immunotherapy is the most often applied strategy because of its effectiveness and ease of application, with an acceptable safety profile. The effectiveness of oral immunotherapy in patients with egg, cow’s milk, and peanut allergy has been proven both in terms of raising of the threshold and the development of tolerance, and in some patients, the development of sustainable unresponsiveness. Although oral immunotherapy is an effective treatment for food allergy, several limitations, including a long duration and a significant rate of reported adverse events, reduces its success.
  • 109
  • 19 Jan 2024
Topic Review
Approaches to Estimate Minimum Clinically Important Differences
The origin of evidence-based medicine (EBM) dates back to the 1970s. This paradigm emphasizes a methodical evaluation of the evidence for use in health care decision-making, along with the knowledge of decision-makers and the expectations and values of patients. There is a growing awareness of correlating statistically significant results with clinical relevance in clinical trials to avoid the misinterpretation of study findings and prevent patients from being exposed to unnecessary therapies. The concept of “clinically important difference”, which has been developed as a way to overcome the drawbacks of a “statistically significant difference” and which represents a change that the patient feels, is noteworthy. The minimum clinically important difference (MCID) is the threshold value for such a change, first described by Jaeschke and colleagues in 1989. There has been a shift towards considering clinical relevance rather than just statistical significance in interpreting results from clinical trials. Multiple rating scales, such as the Modified Rankin Scale (mRS) and the Barthel Index (BI), are commonly used as outcome measures in both daily neurological practice and clinical trials, including stroke trials.
  • 180
  • 18 Jan 2024
Topic Review
Secondary Metabolites from the Genus Acremonium
Acremonium fungi is one of the greatest and most complex genera in Hyphomycetes, comprising 130 species of marine and terrestrial sources. The past decades have witnessed substantial chemical and biological investigations on the diverse secondary metabolites from the Acremonium species. To date, over 600 compounds with abundant chemical types as well as a wide range of bioactivities have been obtained from this genus, attracting considerable attention from chemists and pharmacologists. 
  • 118
  • 18 Jan 2024
Biography
José Juan escobar-Chávez
Dr. Escobar-Chávez is a professor at the Faculty of Chemistry and Pharmacy; Autonomous University of Mexico (UNAM). He joined the faculty in 1998. Doctor Degree in Chemical Sciences from the National Autonomous University of Mexico; Bachelor's Degree in Pharmaceutical Chemist Biologist in the area of ​​Pharmacy. He has carried out 2 postdoctoral research stays with a duration of one year in
  • 187
  • 18 Jan 2024
Topic Review
Devices for Tooth Mobility Measurement
Evaluating tooth mobility is clinically significant, not only for diagnosing periodontal tissues but also in determining the overall periodontal treatment plan. Numerous studies related to tooth mobility have been conducted, including the proposal of various classifications as well as the development of electronic devices for objective measurement. 
  • 284
  • 18 Jan 2024
Topic Review
Maxillary Anterior Teeth Dimensions and Relative Width Proportions
Predictable results in the aesthetic treatment of anterior teeth can be obtained by resorting to the concept of dental aesthetics and, in particular, defining the ideal tooth dimensions and proportions to obtain a harmonious smile.
  • 238
  • 18 Jan 2024
Topic Review
Radioactive Iodine Refractory Differentiated Thyroid Cancer
Patients with differentiated thyroid cancer usually present with early-stage disease and undergo surgery followed by adjuvant radioactive iodine ablation, resulting in excellent clinical outcomes and prognosis.
  • 138
  • 18 Jan 2024
Topic Review
Cancer Tissue-Derived and Peripheral Blood Biomarkers in HGSOC
High-grade serous ovarian cancer (HGSOC) is one of the most lethal tumors generally and the most fatal cancer of the female genital tract. The approved standard therapy consists of surgical cytoreduction and platinum/taxane-based chemotherapy, and of targeted therapy in selected patients. The main therapeutic problem is chemoresistance of recurrent and metastatic HGSOC tumors which results in low survival in the group of FIGO III/IV. Therefore, the prediction and monitoring of chemoresistance seems to be of utmost importance for the improvement of HGSOC management. 
  • 207
  • 18 Jan 2024
Topic Review
Common Misconceptions about Diet and Breast Cancer
Breast cancer is the most prevalent cancer among women. Diet significantly influences the development, progression, and prevention of breast cancer.
  • 93
  • 18 Jan 2024
Topic Review
Psychotropic Medications and Dermatological Side Effects
Psychotropic medications, commonly prescribed for psychiatric disorders, can have underappreciated dermatological side effects. Adverse reactions (ADRs) to these medications are a leading cause of discontinuations and therefore can lead to poor compliance. The diagnosis of drug-induced dermatological reactions is a significant challenge due to factors such as multifactorial aetiology and complex presentation.
  • 188
  • 18 Jan 2024
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