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Topic Review
Religious Trauma Syndrome
Religious trauma syndrome (RTS) is recognized in psychology and psychotherapy as a set of symptoms, ranging in severity, experienced by those who have participated in and left behind authoritarian, dogmatic, and controlling religious groups and belief systems. Symptoms include cognitive, affective, functional, and social/cultural issues as well as developmental delays. RTS occurs in response to two-fold trauma: first the prolonged abuse of indoctrination from a controlling religious community, and secondly the act of leaving the controlling religious community. RTS has developed as its own heuristic collection of symptoms informed by psychological theories of trauma originating in PTSD, C-PTSD and betrayal trauma theory, taking relational and social context into account when approaching further research and treatment. The term religious trauma syndrome was coined in 2011 by psychologist Marlene Winell in an article for British Association for Behavioural and Cognitive Psychotherapies, though the phenomenon was recognized long before that. The term has circulated among psychotherapists, former fundamentalists, and others recovering from religious indoctrination. Winell explains the need for a label and the benefits of naming the symptoms encompassed by RTS as similar to naming anorexia as a disorder: the label can lessen shame and isolation for survivors while promoting diagnosis, treatment, and training for professionals who work with those suffering from the condition. Survivors report relief when they find out that RTS is “real.”
  • 1.7K
  • 22 Nov 2022
Topic Review
GADD45A
The growth arrest and DNA damage-inducible 45 alpha (GADD45A) gene encodes a 165 aa protein localized in the nucleus, whose level is highest in the G1 phase of the cell cycle, with a substantial reduction in S. The involvement of GADD45A in the cell cycle regulation and interaction with other proteins underline its function in the cellular DNA damage response and maintaining genomic stability, which, in turn, determines its high potential in cancer transformation. The protective role of GADD45A in DNA damage-induced tumorigenesis is the main biological function of this protein, but exact mechanism of it is not known. Emerging evidence suggests that GADD45A may be important in breast cancer and several molecular pathways were reported to underline this importance, including Ras, mitogen-activated protein kinase 8 (MAPK8), JNK (c-Jun N-terminal kinase) and p38. GADD45A may play a tumor-suppressor role by induction of senescence and apoptosis in cancer cells. However, it was also shown that GADD45A may promote tumorigenesis via the GSK3 β (glycogen synthase kinase 3 beta)/β-catenin signaling. Therefore, GADD45A may function as either a tumor promotor or suppressor, depending on the kind of oncogenic stress, and these two functions are mediated by different signaling pathways.
  • 1.7K
  • 01 Nov 2020
Topic Review
Bioactive Compounds from Rice Varieties
Consumption of pigmented rice as a staple food is rapidly increasing due to their healthy prospective and considered as functional food ingredients. Greater interest has been shown in many color rice varieties due to their multiple biological activities. The phenolic compounds have been found to consist of anthocyanidins, ferulic acid, diferulates, anthocyanins and polymeric proanthocyanidins. Anthocyanin is located in the bran layers of the rice kernel, while phenolic acids are mainly present in the bran layers of rice, existing as free, conjugated and bound forms. Keeping in view the several health benefits associated with the functional ingredients, such as anti-inflammatory, antioxidative and anticancer effects, pigmented rice is considered as a functional food and food ingredient in many Asian countries. 
  • 1.7K
  • 10 Jan 2021
Topic Review
Pilot Findings on SARS-CoV-2 Vaccine-Induced Pituitary Diseases
Since the emergence of the COVID-19 pandemic at the end of 2019, a massive vaccination campaign has been undertaken rapidly and worldwide. Like other vaccines, the COVID-19 vaccine is not devoid of side effects. Typically, the adverse side effects of vaccination include transient headache, fever, and myalgia. Endocrine organs are also affected by adverse effects. The major SARS-CoV-2 vaccine-associated endocrinopathies reported since the beginning of the vaccination campaign are thyroid and pancreas disorders. SARS-CoV-2 vaccine-induced pituitary diseases have become more frequently described in the literature. 
  • 1.7K
  • 08 Dec 2022
Topic Review
OX40-OX40L Inhibition for the Treatment of Atopic Dermatitis
OX40 and OX40L are two checkpoint molecules that bind to potentiate pro-inflammatory T-cell responses that are pivotal to atopic dermatitis pathogenesis. Two OX40-OX40L inhibitors, rocatinlimab and amlitelimab, are being developed for the treatment of atopic dermatitis. Rocatinlimab, an anti-OX40 antibody, was evaluated in phase 2b, a randomized, placebo-controlled clinical trial. At week 16, rocatinlimab groups achieved a greater reduction in the EASI percentage change from the baseline (−48.3% to −61.1%) against the placebo (−15.0%; p < 0.001), and clinical response was maintained 20 weeks after the treatment had ceased. Amlitelimab, an anti-OX40L antibody, was studied in a 12-week treatment phase 2a clinical trial, with a significant efficacy response observed within 2 weeks. At week 16, amlitelimab groups reached the EASI mean percentage change from the baseline of −69.9% and −80.1% versus the placebo (−49.4%; p = 0.072 and p = 0.009). Among the responders, 68% of amlitelimab patients were sustained 24 weeks following the last dose. Both treatments were shown to be safe and well tolerated. The evidence points to OX40-OX40L inhibitors as future options for atopic dermatitis treatment with potential disease-modifying effects.
  • 1.7K
  • 17 Feb 2023
Topic Review
Glucose
Glucose is a major macronutrient and a vital homeostatic factor in the regulation of energy metabolism maintained in a narrow range of 4.4 to 6.1 mmol/L or about 1.0 g/L in the blood of healthy humans as measured in the fasting state. However, glucose per se is not the predominant component of mixed food, and its main source in the diet is poly- and oligosaccharides, which undergo enzymatic hydrolysis to monomers in the small intestine during luminal and membrane digestion. Depending on the food composition, the site of the gastrointestinal tract (GIT) and time of the day, the postprandial glucose concentrations in the GIT lumen can vary in a large range and can be several times higher than in the blood.
  • 1.7K
  • 14 Aug 2021
Topic Review
Avoidant Personality Disorder
Avoidant personality disorder (AvPD) is a Cluster C personality disorder in which the main coping mechanism of those affected is avoidance of feared stimuli. Those affected display a pattern of severe social anxiety, social inhibition, feelings of inadequacy and inferiority, extreme sensitivity to negative evaluation and rejection, and avoidance of social interaction despite a strong desire for intimacy. People with AvPD often consider themselves to be socially inept or personally unappealing and avoid social interaction for fear of being ridiculed, humiliated, rejected, or disliked. They often avoid becoming involved with others unless they are certain they will be liked. Childhood emotional neglect (in particular, the rejection of a child by one or both parents) and peer group rejection are associated with an increased risk for its development; however, it is possible for AvPD to occur without any notable history of abuse or neglect.
  • 1.7K
  • 20 Oct 2022
Topic Review
Psychiatric Survivors Movement
The psychiatric survivors movement (more broadly consumer/survivor/ex-patient movement) is a diverse association of individuals who either currently access mental health services (known as consumers or service users), or who are survivors of interventions by psychiatry, or who are ex-patients of mental health services. The psychiatric survivors movement arose out of the civil rights movement of the late 1960s and early 1970s and the personal histories of psychiatric abuse experienced by some ex-patients. The key text in the intellectual development of the survivor movement, at least in the USA, was Judi Chamberlin's 1978 text, On Our Own: Patient Controlled Alternatives to the Mental Health System. Chamberlin was an ex-patient and co-founder of the Mental Patients' Liberation Front. Coalescing around the ex-patient newsletter Dendron, in late 1988 leaders from several of the main national and grassroots psychiatric survivor groups felt that an independent, human rights coalition focused on problems in the mental health system was needed. That year the Support Coalition International (SCI) was formed. SCI's first public action was to stage a counter-conference and protest in New York City , in May, 1990, at the same time as (and directly outside of) the American Psychiatric Association's annual meeting. In 2005 the SCI changed its name to MindFreedom International with David W. Oaks as its director. Common themes are "talking back to the power of psychiatry", rights protection and advocacy, and self-determination. While activists in the movement may share a collective identity to some extent, views range along a continuum from conservative to radical in relation to psychiatric treatment and levels of resistance or patienthood.
  • 1.7K
  • 23 Nov 2022
Topic Review
Role of NF-kB in Alzheimer’s Disease
Alzheimer’s Disease (AD) is the most common neurodegenerative disease worldwide, with a high prevalence that is expected to double every 20 years. Besides the formation of Aβ plaques and neurofibrillary tangles, neuroinflammation is one the major phenotypes that worsens AD progression. Indeed, the nuclear factor-κB (NF-κB) is a well-established inflammatory transcription factor that fuels neurodegeneration.
  • 1.7K
  • 23 Aug 2022
Topic Review
DPP4 Inhibitors on COVID19 Outcomes
Although relatively new in the therapeutic landscape for managing type 2 diabetes (T2D), dipeptidyl-peptidase 4 (DPP4) inhibitors have gained widespread popularity, due to their glycemic efficacy, low risk of hypoglycemic episodes and oral route of administration. DPP4, a cell-bound serine protease abundantly expressed on lymphocytes, epithelial and endothelial cells, plays critical roles in the modulation of glucose homeostasis and inflammatory immune responses. Also, given its potential to serve as an adjunctive functional receptor for the emerging Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) to gain entry into the host, inhibition of DPP4 has been proposed as an alternative and multifaceted strategy to prevent severe clinical manifestations of the SARS-CoV-2 related illness (COVID-19), which are commonly observed in T2D patients. However, the inherent risk of mast cells hyper-activation and the lack of a clear demonstration of SARS-CoV-2 binding to DPP4, may raise some concerns and controversy.
  • 1.7K
  • 06 Nov 2020
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