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Topic Review
Association between Sodium Channels and Gynecological Cancers
Targeted therapy against cancer plays a key role in delivering safer and more efficient treatments. In the last decades, ion channels have been studied for their participation in oncogenic processes because their aberrant expression and/or function have been associated with different types of malignancies, including ovarian, cervical, and endometrial cancer. 
  • 374
  • 13 Jun 2023
Topic Review
Non-Invasive Diagnosis of Chronic Coronary Syndrome
Coronary artery disease is still a major cause of death and morbidity worldwide. In the setting of chronic coronary disease, demonstration of inducible ischemia is mandatory to address treatment. Consequently, scientific and technological efforts were made in response to the request for non-invasive diagnostic tools with better sensitivity and specificity. Clinicians have at their disposal a wide range of stress-imaging techniques. Among others, stress cardiac magnetic resonance (S-CMR) and computed tomography perfusion (CTP) techniques both demonstrated their diagnostic efficacy and prognostic value in clinical trials when compared to other non-invasive ischemia-assessing techniques and invasive fractional flow reserve measurement techniques. 
  • 304
  • 12 Jun 2023
Topic Review
Combination Therapy to Fight Oral Cancer
Combination therapy has become the standard practice for the treatment of locally advanced oral cancer, emerging as an effective approach in improving outcomes. Despite stepwise advances in our understanding of the molecular basis of oral carcinogenesis, the complexity and diversity of pathways and mechanisms that drive cancer progression and invasion may compromise the success of the treatment when used in a monotherapy approach. Therefore, combinatorial modalities that simultaneously target different pathways are expected to result in more clinical benefit for patients. 
  • 401
  • 12 Jun 2023
Topic Review
Treatment of Opisthorchis viverrini
Opisthorchiasis due to Opisthorchis viverrini infection continues to be a significant public healthcare concern in various subregions of Southeast Asia, particularly in Thailand, Laos, Cambodia, Myanmar, and Vietnam. The mainstay of treatment of opisthorchiasis is praziquantel, while treatment of opisthorchiasis-associated cholangiocarcinoma depends on its anatomic subtype and resectability.
  • 313
  • 12 Jun 2023
Topic Review
Magnetic Resonance-Guided Radiotherapy
Magnetic resonance-guided radiotherapy (MRgRT) is an emerging radiotherapy technology combining real-time magnetic resonance imaging and radiation delivery. By administering radiation with a linear accelerator with built in low-field or high-field MRI, practitioners have a greater ability to align to the target for daily set-up, precisely track the motion of and thereby target or avoid tissues and adapt to inter-treatment daily changes. This decreased uncertainty has implications for facilitating smaller, less-toxic treatment margins, potentially allowing delivery of higher dose radiotherapy that will lead to better control of tumors. The technology has already found success in treating breast, prostate, pancreatic, liver, lung, and limited metastatic cancers, in addition to non-oncologic indications such as cardiac ablation. 
  • 279
  • 12 Jun 2023
Topic Review
Acetyl Zingerone
The cumulative damage skin sustains from exposure to environmental stressors throughout life exerts significant effects on skin aging and cancer development. One of the main ways by which environmental stressors mediate their effects within skin is through induction of reactive oxygen species (ROS).
  • 920
  • 12 Jun 2023
Topic Review
Infections Secondary to Targeted Therapies in Hematological Malignancies
Concurrent infections in hematological malignancies (HM) are major contributors to adverse clinical outcomes, including prolonged hospitalization and reduced life expectancy. Individuals diagnosed with HM are particularly susceptible to infectious pathogens due to immunosuppression, which can either be inherent to the hematological disorder or induced by specific therapeutic strategies. The treatment paradigm for HM has witnessed a tremendous shift, from broad-spectrum treatment approaches to more specific targeted therapies. The therapeutic landscape of HM is constantly evolving due to the advent of novel targeted therapies and the enhanced utilization of these agents for treatment purposes. By initiating unique molecular pathways, these agents hinder the proliferation of malignant cells, consequently affecting innate and adaptive immunity, which increases the risk of infectious complications.
  • 245
  • 12 Jun 2023
Topic Review
Currently Existing Pathogenesis of Oral Lichen Planus
Lichen ruber planus (LP) is a chronic, autoimmune, inflammatory mucocutaneus disease that influences the hair, skin, and nails, as well as the genital, oesophageal, laryngeal, conjunctival, and oral mucosa. Mostly, it is isolated only in the oral cavity without involving the skin or other mucous membranes. Oral lichen planus (OLP) is considered a T cell-mediated chronic inflammatory process activated by an unknown antigen, making basal keratinocytes vulnerable to a cytotoxic cell mediated immune response.
  • 345
  • 12 Jun 2023
Topic Review
The Functions of CD30
Previous studies have identified the functional roles of CD30, a member of the tumor necrosis factor receptor superfamily, in CD30-expressing malignant lymphomas, including Hodgkin lymphoma (HL), anaplastic large cell lymphoma (ALCL), and a portion of peripheral T-cell lymphoma (PTCL), adult T-cell leukemia/lymphoma (ATL), and diffuse large B-cell lymphoma (DLBCL). 
  • 226
  • 12 Jun 2023
Topic Review
Myocardial Perfusion and Flow Imaging with PET
Positron emission tomography (PET) is a non-invasive, functional imaging test utilizing ionizing radiation, the source of which is a radioactive isotope (radionuclide) administered to the patient. Myocardial perfusion imaging (MPI) with radionuclide PET is one of the non-invasive imaging methods that can provide rapid and accurate information about the extent of ischemia.
  • 539
  • 12 Jun 2023
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