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Biography
Corrado I. Angelini
Corrado Angelini (born August 3, 1941) is a neurologist with a particular interest in neurometabolic and neuromuscular disorders. He received his medical degree at the University of Padova and has done his residency at the University of Padova, Mayo Clinic. He passed FLEX Examination in Minneapolis, in 1973 and obtained the North Dakota State License Examination (No. 3339), since 1973, he has he
  • 776
  • 06 May 2023
Topic Review
Excipients to Inhibit Efflux Transporters
Efflux transporters distributed at the apical side of human intestinal epithelial cells actively transport drugs from the enterocytes to the intestinal lumen, which could lead to extremely poor absorption of drugs by oral administration. Efflux transporters in the gastrointestinal tract mainly include P-gp, MRPs and BCRP.
  • 776
  • 17 Jun 2022
Topic Review
Retrospective Memory
Retrospective memory is the memory of people, words, and events encountered or experienced in the past. It includes all other types of memory including episodic, semantic and procedural. It can be either implicit or explicit. In contrast, prospective memory involves remembering something or remembering to do something after a delay, such as buying groceries on the way home from work. However, it is very closely linked to retrospective memory, since certain aspects of retrospective memory are required for prospective memory.
  • 776
  • 06 Dec 2022
Topic Review
Astrocytes in Depression and Alzheimer’s Disease
Astrocytes play a key role in the functioning of neurons in norm and pathology, being a target for stress and glucocorticoids, are a promising target for the treatment of stress-dependent depression and Alzheimer’s disease (AD). Depression, as a mental disorder, is characterized by two core symptoms, depressed mood and loss of interest or pleasure in nearly all activities, and may be accompanied by other symptoms such as cognitive impairments, sleep disturbance, psychomotor retardation or agitation, feelings of worthlessness or excessive or inappropriate guilt.
  • 775
  • 20 May 2022
Topic Review
Pathogenesis and Management of Brugada Syndrome
Brugada syndrome (BrS) is a primary electrical disease associated with arrhythmias and an elevated risk of sudden cardiac death (SCD). It was described by Pedro and Josep Brugada in 1992 as a syndrome comprised of “right bundle branch block, persistent ST segment elevation and SCD”. The prevalence of BrS electrocardiogram (ECG) patterns differs largely among various regions and populations of the world. Patients with BrS are considered symptomatic if they have history of aborted SCD, ventricular fibrillation (VF), sustained ventricular tachycardia (VT), or syncope. BrS usually presents during the third or fourth decade of life, and about 63% of patients are asymptomatic at diagnosis. However, syncope or major arrhythmic events (MAE) can occur at any age, or SCD may even present as the first event. BrS contributes towards sudden infant death syndrome, SCD in children, and is estimated to cause about 20% of all SCDs in individuals with anatomically normal cardiac structures.
  • 775
  • 18 Apr 2022
Topic Review
Sustainable Development Goals in the COVID-19 Pandemic
The Sustainable Development Goals are a global call to action to end poverty, close the gender gap, protect the planet, and improve the lives of people around the world. In 2015, the United Nations General Assembly adopted 17 goals as part of the 2030 Agenda for Sustainable Development, which sets out a plan to achieve the goals in 15 years. However, the COVID-19 pandemic crisis has been a turning point in the achievement of these goals, due to all its consequences at the political, economic, and socio-cultural levels.
  • 775
  • 28 Jun 2022
Topic Review
Acute Myeloid Leukemia Stem Cells
Relapse after apparent remission remains a major cause of death in patients with acute myeloid leukemia (AML). On the cellular level, leukemia relapse is considered to emerge from subpopulations of therapy-resistant leukemic stem cells (LSC). Identification and targeting of LSC are thus most important goals for AML treatment. However, AML and their LSC are highly heterogeneous.
  • 775
  • 29 Dec 2020
Topic Review
AhR in the Hallmarks of Brain Aging
AhR, a member of the basic helix-loop-helix (bHLH)-PAS superfamily, performs various functions within the brain. It is an ancient protein that possesses shared functions and structures across various species in the evolutionary tree. It is widely distributed in various regions of the brain, such as the hippocampus, the cortex, and the hypothalamus, and its expression changes during the course of brain development.
  • 775
  • 20 Oct 2021
Topic Review
Bisphenol A in Related Pathological Conditions
Bisphenol A (BPA) is one of the so-called endocrine disrupting chemicals (EDCs) and is thought to be involved in the pathogenesis of different morbid conditions: immune-mediated disorders, type-2 diabetes mellitus, cardiovascular diseases, and cancer. 
  • 775
  • 27 Mar 2023
Topic Review
Immune Checkpoint Agents
Immune checkpoint inhibitors represent a promising treatment choice in many kind of tumours, including hepatocellular carcinoma (HCC). In this review, we provide an overview of the role of these new agents in the management of HCC according to the Barcelona staging system, alongside with a critical evaluation of the current status and future directions. Several clinical trials are focusing on the use of immunotherapy in HCC, alone or in combinations with antiangiogenetic agents as well as local treatment. However, the majority of those trials are still ongoing and, until now, only a few combinations were approved in the clinical practice from the regulatory authorities. Additionally, decisions about the choice of the right sequence of treatments in HCC patients in the light of the “continuum of care” principles, is still hard. In fact, it requires careful consideration in a multidisciplinary context in order to ensure a tailored treatment for each patient. 
  • 775
  • 09 Nov 2020
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