Subject:
All Disciplines Arts & Humanities Biology & Life Sciences Business & Economics Chemistry & Materials Science Computer Science & Mathematics Engineering Environmental & Earth Sciences Medicine & Pharmacology Physical Sciences Public Health & Healthcare Social Sciences
Sort:
Hottest Latest Alphabetical (A-Z) Alphabetical (Z-A)
Type:
All Topic Review Biography
Topic Review
Acidophilic Lactic Acid Bacteria in Foods and Health
Acidophilic lactic acid bacteria (LAB) are the most commonly used low-pH microorganisms in the healthcare, pharmaceutical, and food industries.
  • 555
  • 08 Aug 2023
Topic Review
Stages, Grades and Types of  Bladder Cancer
The bladder is a hollow organ located in the lower abdominal region. The bladder is contiguous with the ureters above, through which urine flows from the kidneys, and the urethra below, which dispels urine from the body. There are four parts to the bladder, the apex or dome, body, fundus, and neck. The apex is the anterosuperior part of the bladder that points towards the abdominal wall. The fundus, or base, is the posteroinferior part of the bladder. The fundus lies on the inferior aspect of the proximal wall while the apex lies on the anterior aspect of the wall, extending towards the pubic symphysis. The body of the bladder is the large area situated between the apex and the fundus. The neck of the bladder is the constricted part of the bladder that leads to the urethra. The upper part of the bladder consists of the apex and body which are above the ureteric orifices. The lower part consists of the fundus, neck, and trigone. The trigone is an inverted triangular-shaped area of space that is made entirely of smooth muscle. Its superolateral angles are formed by the ureteric orifices. The neck lies at the base of the trigone and it is the most inferior point of the bladder.
  • 276
  • 08 Aug 2023
Topic Review
The Chiari Malformation and the ‘Arnold-Chiari’ Eponym
Chiari malformations are a group of craniovertebral junction anomalies characterized by the herniation of cerebellar tonsils below the foramen magnum, often accompanied by brainstem descent. The existing classification systems for Chiari malformations have expanded from the original four categories to nine, leading to debates about the need for a more descriptive and etiopathogenic terminology.
  • 405
  • 08 Aug 2023
Topic Review
Priapism at Diagnosis of Pediatric Chronic Myeloid Leukemia
Pediatric chronic myeloid leukemia (CML) is a very rare malignancy (age-related incidence 0.1/100,000) typically presenting with leucocyte counts >100,000/µL. However, clinical signs of leukostasis are observed at diagnosis in only approximately 10% of all cases and among these, priapism is infrequent.
  • 309
  • 08 Aug 2023
Topic Review
Advancing Regenerative Cellular Therapies in Non-Scarring Alopecia
Alopecia or baldness is a common diagnosis in clinical practice. Alopecia can be scarring or non-scarring, diffuse or patchy. The most prevalent type of alopecia is non-scarring alopecia, with the majority of cases being androgenetic alopecia (AGA) or alopecia areata (AA). AGA is traditionally treated with minoxidil and finasteride, while AA is treated with immune modulators; however, both treatments have significant downsides.
  • 577
  • 08 Aug 2023
Topic Review
Epidemiology, Pathogenesis, and Risk Factors of Knee Osteoarthritis
The knee is the joint most frequently involved in osteoarthritis and represents a significant contributor to patient morbidity and impaired functional status. Major risk factors include genetics, age, sex, mechanical load and obesity/metabolic syndrome. Some studies highlighted the role of obesity and metabolic syndrome in the pathogenesis of knee osteoarthritis not simply through increased mechanical loading but the systemic effects of obesity-induced inflammation. The current concept of knee osteoarthritis is that of a ‘whole joint disease’, which highlights the involvement not only of articular cartilage but also the synovium, subchondral bone, ligaments and muscles. 
  • 329
  • 08 Aug 2023
Topic Review
Glioblastoma Biomarkers in Body Fluids
Glioblastoma (GBM) is a highly aggressive and lethal primary brain cancer that necessitates early detection and accurate diagnosis for effective treatment and improved patient outcomes. Traditional diagnostic methods, such as imaging techniques and tissue biopsies, have limitations in providing real-time information and distinguishing treatment-related changes from tumor progression. Liquid biopsies, used to analyze biomarkers in body fluids, offer a non-invasive and dynamic approach to detecting and monitoring GBM.
  • 273
  • 08 Aug 2023
Topic Review
Subcutaneous Implantable Cardioverter Defibrillator
Subcutaneous implantable cardioverter defibrillators (S-ICDs) are structurally similar to TV-ICDs, being made of a pulse generator and a defibrillator coil. The advantage of S-ICDs concerns the components, which are completely outside of the chest.
  • 384
  • 08 Aug 2023
Topic Review
Fabrication and Current Status of Microneedles
One of the most cutting-edge, effective, and least invasive pharmaceutical innovations is the utilization of microneedles (MNs) for drug delivery, patient monitoring, diagnostics, medicine or vaccine delivery, and other medical procedures (e.g., intradermal vaccination, allergy testing, dermatology, and blood sampling). The MN-based system offers many advantages, such as minimal cost, high medical effectiveness, comparatively good safety, and painless drug application. Drug delivery through MNs can possibly be viewed as a viable instrument for various macromolecules (e.g., proteins, peptides, and nucleic acids) that are not efficiently administered through traditional approaches.
  • 238
  • 08 Aug 2023
Topic Review
Quinones as Neuroprotective Agents
Quinones can in principle be viewed as a double-edged sword in the treatment of neurodegenerative diseases, since they are often cytoprotective but can also be cytotoxic due to covalent and redox modification of biomolecules. Nevertheless, low doses of moderately electrophilic quinones are generally cytoprotective, mainly due to their ability to activate the Keap1/Nrf2 pathway and thus induce the expression of detoxifying enzymes. Some natural quinones have relevant roles in important physiological processes. One of them is coenzyme Q10, which takes part in the oxidative phosphorylation processes involved in cell energy production, as a proton and electron carrier in the mitochondrial respiratory chain, and shows neuroprotective effects relevant to Alzheimer’s and Parkinson’s diseases. Additional neuroprotective quinones that can be regarded as coenzyme Q10 analogues are idobenone, mitoquinone and plastoquinone.
  • 251
  • 08 Aug 2023
  • Page
  • of
  • 1352
Featured Entry Collections
>>

Featured Books

>>
Encyclopedia of Social Sciences
Encyclopedia of COVID-19
Encyclopedia of Fungi
Encyclopedia of Digital Society, Industry 5.0 and Smart City
Video Production Service
Feedback