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Topic Review
Plant-Based Diets Reducing the Main RVO Risk Factors
Retinal vein occlusion (RVO) is the second most common retinal disorder. In comparison to diabetic retinopathy or age-related macular degeneration, RVO is usually an unexpected event that carries a greater psychological impact.
  • 201
  • 26 Sep 2023
Topic Review
Anti-Cancer and Anti-Inflammatory Activities of Betulin
Betulin is a lupane-type pentacyclic triterpene. It consists of four six-membered rings arranged in a trans configuration and one five-membered ring. It is characterized by a range of biological properties, including anti-cancer and anti-inflammatory activities. It is also an origin compound for obtaining derivatives with higher biological activity and better bioavailability.
  • 313
  • 26 Sep 2023
Topic Review Video
Gene Therapies for Epilepsy
Epilepsy is a complex neurological disorder affecting millions worldwide, with a substantial number of patients facing drug-resistant epilepsy. Conventional antiseizure medications (ASMs) have been the cornerstone of epilepsy management, providing significant relief to a large number of patients In the context of epilepsy, gene therapy holds the potential to address the underlying genetic abnormalities that give rise to seizure disorders. By targeting specific genes associated with epilepsy, gene therapy aims to restore normal cellular function and inhibit seizure generation, providing a promising avenue for the development of novel and more targeted epilepsy treatments.
  • 420
  • 26 Sep 2023
Topic Review
Dysferlinopathy
Dysferlinopathy is a disease caused by a dysferlin deficiency due to mutations in the DYSF gene. Dysferlin is a membrane protein in the sarcolemma and is involved in different functions, such as membrane repair and vesicle fusion, T-tubule development and maintenance, Ca2+ signalling, and the regulation of various molecules. Miyoshi Myopathy type 1 (MMD1) and Limb–Girdle Muscular Dystrophy 2B/R2 (LGMD2B/LGMDR2) are two possible clinical presentations, yet the same mutations can cause both presentations in the same family. They are therefore grouped under the name dysferlinopathy. 
  • 202
  • 26 Sep 2023
Topic Review
Hepatitis B Virus Genotypes and Human Populations
Hepatitis B virus (HBV) is a challenge for global health services, affecting millions and leading thousands to end-stage liver disease each year. HBV is classified into ten genotypes (A to J) and more than 40 sub-genotypes based on a genomic divergence of 8% and 4% (intra-genotype variation), respectively.
  • 386
  • 26 Sep 2023
Topic Review
DNA Nanostructures for Ophthalmic Drug Delivery
Nanomedicine in gel or particle formation holds considerable potential for enhancing passive and active targeting within ocular drug delivery systems. The complex barriers of the eye, exemplified by the intricate network of closely connected tissue structures, pose significant challenges for drug administration. Leveraging the capability of engineered nanomedicine offers a promising approach to enhance drug penetration, particularly through active targeting agents such as protein peptides and aptamers, which facilitate targeted release and heightened bioavailability. Simultaneously, DNA carriers have emerged as a cutting-edge class of active-targeting structures, connecting active targeting agents and illustrating their potential in ocular drug delivery applications.
  • 152
  • 26 Sep 2023
Topic Review
Stress of Prematurity in Experience of COVID-19 Pandemic
Stress is a process that triggers various physiological, hormonal and psychological mechanisms in response to a threat, which significantly affects the health of an individual. The COVID-19 pandemic introduced a lot of social changes that required constant adaptation to unfavorable conditions. Maternal stress and anxiety increase the levels of corticotropin-releasing hormone (CRH) in the placenta, which in turn affects the incidence of preterm birth and many other related maternal and neonatal complications.
  • 184
  • 26 Sep 2023
Topic Review
Novel Advances in Treatment of Meningiomas
Meningiomas are extra-axial, slow-growing, and (usually) benign tumors. These tumors arise from meningothelial cells of the arachnoid layer, so they can be encountered anywhere this type of cell is localized.
  • 280
  • 26 Sep 2023
Topic Review
The Intestinal Microbiota in Chronic Liver Disease
Chronic liver disease (CLD) is a significant global health burden, leading to millions of deaths annually. The gut–liver axis plays a pivotal role in this context, allowing the transport of gut-derived products directly to the liver, as well as biological compounds from the liver to the intestine. The gut microbiota plays a significant role in maintaining the health of the digestive system. A change in gut microbiome composition as seen in dysbiosis is associated with immune dysregulation, altered energy and gut hormone regulation, and increased intestinal permeability, contributing to inflammatory mechanisms and damage to the liver, irrespective of the underlying etiology of CLD.
  • 293
  • 26 Sep 2023
Topic Review
The Relationship between Cannabinoids and Cancer
Cannabis is an impressively complex plant, boasting more than 100 cannabinoids in addition to various terpenes and flavonoids. Medical cannabis has seen a rapid expansion in recent years as more patients turn to using it as a solution for various ailments. With more patients turning to this botanical remedy for treatment purposes, a growing demand exists among the scientific and medical communities to investigate how cannabis orchestrates its effects within the body; this goes beyond simply understanding potential merits and risks. The National Cancer Institute acknowledges the therapeutic potential of Cannabis sativa, particularly Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD), in alleviating various symptoms associated with cancer, including pain, appetite loss, nausea, and anxiety. 
  • 143
  • 26 Sep 2023
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