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Topic Review
Natural Benzophenanthridine Alkaloids
Benzophenanthridine alkaloids are a class of isoquinoline compounds, which are widely found in the plants of papaveraceae, corydalis, and rutaceae. Biological activities and clinical studies have shown that benzophenanthridine alkaloids have inhibitory effects on many cancers.
  • 281
  • 13 Oct 2023
Topic Review
Contained Power Morcellation in Laparoscopic Uterine Myoma Surgeries
Uterine fibromas are the most common benign uterine tumors. Although the majority of leiomyomas remain asymptomatic, they can cause serious clinical problems, including abnormal uterine bleeding, pelvic pain, and infertility, which require effective gynecological intervention. Depending on the symptoms as well as patients’ preferences, various treatment options are available, such as medical therapy, non-invasive procedures, and surgical methods. Regardless of the extent of the surgery, the preferred option is the laparoscopic approach. To reduce the risk of spreading occult malignancy and myometrial cells associated with fragmentation of the specimen before its removal from the peritoneal cavity, special systems for laparoscopic contained morcellation have been developed.
  • 220
  • 13 Oct 2023
Topic Review
Macronutrient and Micronutrient Intake in Lung Disease Children
The nutritional and respiratory statuses of critically ill patients are interrelated in such a way that they are interdependent while maintaining a balance. Malnutrition is common in pediatric intensive care unit (PICU) patients and is frequently associated with respiratory failure.
  • 259
  • 13 Oct 2023
Topic Review
Multiple Sclerosis Pathogenesis
Multiple sclerosis (MS) is predominantly an immune-mediated disease of the central nervous system (CNS) of unknown etiology with a possible genetic predisposition and effect of certain environmental factors. It is generally accepted that the disease begins with an autoimmune inflammatory reaction targeting oligodendrocytes followed by a rapid depletion of their regenerative capacity with subsequent permanent neurodegenerative changes and disability.
  • 426
  • 13 Oct 2023
Topic Review
Pharmacokinetics of Tocotrienol
Tocotrienols are valuable nutraceuticals due to their numerous pharmacological properties, particularly in preventing or treating non-communicable diseases, including cardiovascular, musculoskeletal, metabolic, and skin disorders, as well as cancers.
  • 196
  • 13 Oct 2023
Topic Review
Therapeutic Approaches for Gastric Neuroendocrine Neoplasms
Gastric neuroendocrine neoplasms (gNENs) represent rare but increasingly recognized tumors. They are distinguished into three main clinical types (type-1, type-2, and type-3) according to gastrin level and at histological evaluation in well-differentiated G1, G2, or G3 lesions, as well as poorly-differentiated lesions.
  • 345
  • 13 Oct 2023
Topic Review
Aetiology of Bicuspid Aortic Valve
BAV (Bicuspid Aortic Valve) stands as the most prevalent congenital heart condition closely linked to critical and potentially life-threatening cardiac and aortic ailments, including aortic stenosis, aortic insufficiency, aortic aneurysms, and aortic dissection. It is believed that both genetic and epigenetic factors influence the etiology of BAV. Gaining insight into this underlying causative framework is paramount in guiding treatment strategies for BAV and its associated pathologies.
  • 428
  • 12 Oct 2023
Topic Review
Medication-Overuse Headache
Medication-overuse headache (MOH) is a secondary headache that is classified by the third edition of the International Classification of Headache Disorders as a group of headaches attributable to the administration or discontinuation of various substances. MOH occurs more than 15 days per month in patients with preexisting headaches. It occurs as a result of regular (at least 3 consecutive months) overuse (10 or 15 days, depending on the type of medication) of drugs used as acute or symptomatic headache therapy.
  • 283
  • 12 Oct 2023
Topic Review
Microplastics Effects on Kidney Tissues and Cells
Microplastics (MPs) have become ubiquitous and humans are exposed daily to inhalation or ingestion of plastic microparticles. Studies performed using mainly spectroscopy or spectrometry-based techniques have shown astounding evidence for the presence of MPs in human tissues, organs and fluids. The placenta, meconium, breast milk, lung, intestine, liver, heart and cardiovascular system, blood, urine and cerebrovascular liquid are afflicted by MPs’ presence and deposition. 
  • 353
  • 12 Oct 2023
Topic Review
Astrocyte Therapy in Parkinson’s Disease
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons. While neuronal dysfunction is central to PD, astrocytes also play important roles, both positive and negative, and such roles have not yet been fully explored. 
  • 269
  • 12 Oct 2023
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