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All Topic Review Biography
Topic Review
Cell Culture Model in Lung Cancer
2D cell culture provides valuable information on how therapeutic agents act on tumor cells, it cannot quantify how the tumor microenvironment influences the response to therapy.
  • 359
  • 23 Oct 2023
Topic Review
The Initial Hepatitis B Virus-Hepatocyte Genomic Integrations
Hepatitis B virus (HBV) and its close relative woodchuck hepatitis virus (WHV) belong to the hepadnaviral family. Both are highly oncogenic DNA viruses, and their persistent infection and integration into the host’s hepatocyte genome are the main contributors to the development of hepatocellular carcinoma (HCC). 
  • 174
  • 23 Oct 2023
Topic Review
CAR-T Cell Therapy Recipients Admitted to the ICU
To better understand immunotherapy-related complications from an ICU standpoint, acknowledge the deteriorating patient on the ward, reduce the intensive care unit (ICU) admission rate, advance ICU care, and improve the outcomes of these patients, a standard of care and research regarding CAR-T cell-based immunotherapies should be created. 
  • 281
  • 23 Oct 2023
Topic Review
Natural Antioxidant in Myocardial Infarction/Ischemic Stroke Injury Treatment
Natural antioxidants are present in low concentrations within cells. They reduce free radicals to provide a protection system against vascular diseases. They have a strong potential to inhibit oxidative stress (OS), lipid peroxidation and the oxidation of breakdown products. Natural antioxidants can function either individually or synergistically to remove free radicals generated during oxidative metabolism, thus maintaining the redox balance.
  • 165
  • 23 Oct 2023
Topic Review
Current Biomarker Strategies in Autoimmune Neuromuscular Diseases
Inflammatory neuromuscular disorders encompass a diverse group of immune-mediated diseases with varying clinical manifestations and treatment responses. The identification of specific biomarkers has the potential to provide valuable insights into disease pathogenesis, aid in accurate diagnosis, predict disease course, and monitor treatment efficacy. 
  • 173
  • 23 Oct 2023
Topic Review
Clinical Management and Therapy of Precocious Puberty
Puberty identifies the transition from childhood to adulthood. Precocious puberty is the onset of signs of pubertal development before age eight in girls and before age nine in boys, it has an incidence of 1/5000–1/10,000 with an F:M ratio ranging from 3:1 to 20:1. Precocious puberty can be divided into central, also known as gonadotropin-dependent precocious puberty or true precocious puberty, and peripheral, also recognized as gonadotropin-independent precocious puberty or precocious pseudopuberty. 
  • 205
  • 23 Oct 2023
Topic Review
Neurophysiology in Managing Patients with Chiari Malformations
Chiari malformation type 1 (CM1) includes various congenital anomalies that share ectopia of the cerebellar tonsils lower than the foramen magnum, in some cases associated with syringomyelia or hydrocephalus. CM1 can cause dysfunction of the brainstem, spinal cord, and cranial nerves. This functional alteration of the nervous system can be detected by various modalities of neurophysiological tests, such as brainstem auditory evoked potentials, somatosensory evoked potentials, motor evoked potentials, electromyography and nerve conduction studies of the cranial nerves and spinal roots, as well as brainstem reflexes.
  • 229
  • 23 Oct 2023
Topic Review
Pharmacokinetic Analysis of Ethanol in a Human Study
In the pharmacokinetic analysis of ethanol after oral administration, only single- or two-compartment models are used, but their precision in estimating pharmacokinetic parameters might be insufficient. Pharmacokinetic parameters obtained using pharmacokinetic models differ depending on the type of model used. The estimated pharmacokinetic parameters depend on the type of model used. The classic Widmark model in particular overestimated the fraction of absorbed ethanol from the gastrointestinal system to systemic circulation. 
  • 428
  • 23 Oct 2023
Topic Review
Applications of Zebrafish in Biology
Zebrafish is a crucial in vivo model for lung cancer research and is widely employed in studies focusing on cancer proliferation, metastasis, and angiogenesis. It plays a pivotal role in cancer drug development, being used for target validation, compound screening, and personalized therapy.
  • 221
  • 23 Oct 2023
Topic Review
Exercise-Induced Gastrointestinal Symptoms in Endurance Sports
Strenuous exercise can be associated with “Exercise Induced Gastrointestinal Syndrome” (Ex-GIS), a clinical condition characterized by a series of gastrointestinal (GI) disturbances that may impact the physical and psychological performance of athletes. The pathophysiology comprises multi-factorial interactions between the GI tract and the circulatory, immune, enteric, and central nervous systems. 
  • 286
  • 23 Oct 2023
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