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Topic Review
Ankle and Foot Arthroplasty and Prosthesis
The foot and ankle serve vital roles in weight bearing, balance, and flexibility but are susceptible to many diverse ailments, making treatment difficult. More commonly, Total Ankle Arthroplasty (TAA) and Total Talus Replacement (TTR) are used for patients with ankle degeneration and avascular necrosis of the talus, respectively. Ankle prosthesis and orthosis are also indicated for use with lower limb extremity amputations or locomotor disability, leading to the development of powered exoskeletons. However, patient outcomes remain suboptimal, commonly due to the misfitting of implants to the patient-specific anatomy. Additive manufacturing (AM) is being used to create customized, patient-specific implants and porous implant cages that provide structural support while allowing for increased bony ingrowth and to develop customized, lightweight exoskeletons with multifunctional actuators. AM implants and devices have shown success in preserving stability and mobility of the joint and achieving fast recovery, as well as significant improvements in gait rehabilitation, gait assistance, and strength for patients. 
  • 261
  • 20 Nov 2023
Topic Review
NMDA Receptors and Anti-GluN Autoantibodies in Central Disorders
Autoantibodies against NMDA and AMPA receptors have been identified in the central nervous system of patients suffering from brain disorders characterized by neurological and psychiatric symptoms. It has been demonstrated that these autoantibodies can affect the functions and/or the expression of the targeted receptors, altering synaptic communication. The importance to clarify, in preclinical models, the molecular mechanisms involved in the autoantibody-mediated effects has emerged in order to understand their pathogenic role in central disorders, but also to propose new therapeutic approaches for preventing their deleterious central consequences.
  • 229
  • 20 Nov 2023
Topic Review
ECG Signs in Cardiac Resynchronization Therapy Response Prediction
Cardiac resynchronization therapy (CRT) is a cornerstone therapeutic opportunity for selected patients with heart failure. For optimal patient selection, no other method has been proven to be more effective than the 12-lead ECG, and hence ECG characteristics are extensively researched. The evaluation of particular ECG signs before the implantation may improve selection and, consequently, clinical outcomes. The definition of a true left bundle branch block (LBBB) seems to be the best starting point with which to select patients for CRT. Although there are no universally accepted definitions of LBBB, using the classical LBBB criteria, some ECG parameters are associated with CRT response. In patients with non-true LBBB or non-LBBB, further ECG predictors of response and non-response could be analyzed, such as QRS fractionation, signs of residual left bundle branch conduction, S-waves in V6, intrinsicoid deflection, or non-invasive estimates of Q-LV which are described in newer publications. 
  • 652
  • 20 Nov 2023
Topic Review
Restricted Mean Survival Time to Lung Cancer
Restricted mean survival time (RMST) is a new tool that helps researchers to better address the survival in studies with immune checkpoint inhibitors (ICIs) treatment where the hazard assumption (PH) fails, and the long-rank test is less efficient due to the existence of the long-term responses and delayed treatment effects. Patients with immune-related adverse events (irAEs) have a better prognosis than those without irAEs in the first-line settings. The Eastern Cooperative Oncology Group (ECOG) performance status and the number of organs affected by metastasis must be considered when selecting patients for ICIs treatment.
  • 227
  • 20 Nov 2023
Topic Review
Diversity of Mycolactone-Producing Mycobacteria
Buruli ulcer (BU), a human necrotizing skin disease mainly affecting tropical and subtropical areas, commonly admitted to be caused by Mycobacterium ulcerans worldwide although other mycolactone-producing mycobacteria and even mycobacterium species were found associated with BU or BU-like cases. 
  • 213
  • 20 Nov 2023
Topic Review
The Significance of Biomarkers in Neurodegenerative Disease Pathology
With the inexorable aging of the global populace, neurodegenerative diseases (NDs) like Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS) pose escalating challenges, which are underscored by their socioeconomic repercussions. A pivotal aspect in addressing these challenges lies in the elucidation and application of biomarkers for timely diagnosis, vigilant monitoring, and effective treatment modalities.
  • 132
  • 20 Nov 2023
Topic Review
Implications of Rectal Cancer Radiotherapy on Immune Microenvironment
The efficiency of (chemo-)radiotherapy for rectal cancer is not only determined by the impact on the tumor cells themselves, but also by the highly individual surrounding tumor microenvironment, including immune cells. However, many aspects of the radiation-induced immune response remain to be fully understood. 
  • 183
  • 20 Nov 2023
Topic Review
Genomically-Guided Precision Radiation Treatment
Genetic information is seldom incorporated in formulating radiation treatment recommendations for patients with cancer, even though genetic information is now well established to be prognostic and predictive of cancer outcomes and response to systemic therapy. With the increasing accessibility to and use of genetic testing, tumor, and germline genetic data have the potential to inform clinical decisions by improving the efficacy of radiation treatment and ensuring the safety of treatment delivery.
  • 151
  • 20 Nov 2023
Topic Review
Impact of Communication on Oral Potentially Malignant Disorders
There are no communication protocols for patients who are diagnosed with Oral Potentially Malignant Disorders (OPMDs). Healthcare professionals must develop and practice communication skills throughout their training and practice, starting by incorporating specific training in the dental school curriculum. Due to the limitation in the time available in clinical settings, developing and making available an easily accessible and accurate web-based patient information sheet that could be recommended to an OPMD patient should be considered by professional bodies.
  • 225
  • 20 Nov 2023
Topic Review
Circular RNAs in Metastasis in Breast Cancer
Circular RNAs (circRNAs) are single-stranded closed non-coding RNA molecules that are aberrantly expressed and produce tumor-specific gene signatures in human cancers. They exert biological functions by acting as transcriptional regulators, microRNA sponges, and protein scaffolds, regulating the formation of protein–RNA complexes and, ultimately, regulating gene expression. Triple-negative breast cancer (TNBC) is one of the most aggressive cancers of the mammary gland and has a poor prognosis. Studies of circRNAs in TNBC are limited but have demonstrated these molecules’ pivotal roles in cell proliferation, invasion, metastasis, and resistance to chemo/radiotherapy, suggesting that they could be potential prognostic biomarkers and novel therapeutic targets. 
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  • 20 Nov 2023
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