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Topic Review
Ron Suskind
Ronald Steven "Ron" Suskind (born November 20, 1959) is an American journalist, author, and filmmaker. He was the senior national affairs writer for The Wall Street Journal from 1993 to 2000, where he won the 1995 Pulitzer Prize for Feature Writing for articles that became the starting point for his first book, A Hope in the Unseen. His other books include The Price of Loyalty, The One Percent Doctrine, The Way of the World, Confidence Men, and his memoir Life, Animated: A Story of Sidekicks, Heroes, and Autism, from which he made an Emmy Award-winning, Academy Award-nominated feature documentary. Suskind has written about the George W. Bush Administration, the Barack Obama Administration, and related issues of the United States' use of power.
  • 1.0K
  • 08 Dec 2022
Topic Review
BCR-ABL1 p210 Monitoring
The diagnostic and clinical success of standardization of BCR-ABL1 p210 monitoring in chronic myeloid leukemia patients could be seen as a good example for further standardization of molecular monitoring in other gene rearrangements. This article aims to summarize the steps in the diagnosis and molecular monitoring of p210 BCR-ABL1, as well as to consider the possible future application of a more sophisticated method such as digital polymerase chain reaction.
  • 1.0K
  • 17 Nov 2020
Topic Review
Skin Models for Perspiration Simulation
Skin models offer an in vitro alternative to human trials without their high costs, variability, and ethical issues. Perspiration models, in particular, have gained relevance lately due to the rise of sweat analysis and wearable technology.
  • 1.0K
  • 26 Apr 2021
Topic Review
Endocrine Therapy Resistance
Hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer is the most common breast cancer subtype, and endocrine therapy (ET) remains its therapeutic backbone. Although anti-estrogen therapies are usually effective initially, approximately 50% of HR+ patients develop resistance to ET within their lifetime, ultimately leading to disease recurrence and limited clinical benefit. The recent addition of cyclin-dependent kinase 4 (CDK4) and CDK6 inhibitors (palbociclib, ribociclib, abemaciclib) to ET have remarkably improved the outcome of patients with HR+ advanced breast cancer (ABC) compared with anti-estrogens alone, by targeting the cell-cycle machinery and overcoming some aspects of endocrine resistance.
  • 1.0K
  • 24 Feb 2021
Topic Review
Cardiovascular Effects of Vasopressin and Oxytocin
Oxytocin (Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2; OXY) and arginine vasopressin (Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2; AVP) are nonapeptides, differing only in two aminoacids.  The secretion of OXY and AVP is influenced by changes in body fluid osmolality, blood volume, blood pressure, hypoxia, and stress. AVP and OXY receptors are present in several regions of the brain (cortex, hypothalamus, pons, medulla, and cerebellum) and in the peripheral organs (heart, lungs, carotid bodies, kidneys, adrenal glands, pancreas, gastrointestinal tract, ovaries, uterus, thymus). Hypertension, myocardial infarction, and coexisting factors, such as pain and stress, have a significant impact on the secretion of oxytocin and vasopressin and on the expression of their receptors.
  • 1.0K
  • 10 Nov 2021
Topic Review
Nitrogen-Based Alkylating Anticancer Agents
Despite the significant progress in anticancer drug development over recent years, there is a vital need for newer agents with unique, but still effective, mechanisms of action in order to treat the disease, particularly the highly aggressive and drug resistant types. Alkylating agents, in particular nitrogen-based alkylators, are commonly used to treat hematological and solid malignancies; they exert their antineoplastic effects at all phases of the cell cycle and prevent reproduction of tumor cells. Certain alkylating agents have been designed to be more lipophilic, enabling the compound to penetrate the cell and enhance its alkylating activity against tumors. This review details the evolution of currently available alkylating agents and their profiles, with a focus on nitrogen-based alkylating agents, as important anticancer therapy strategies.
  • 1.0K
  • 27 Mar 2021
Topic Review
Gastroesophageal Adenocarcinoma
The World Health Organization (WHO) classified gastric cancer into tubular, papillary, mucinous, poorly cohesive (including Lauren diffuse type), and mixed variants. 
  • 1.0K
  • 20 Jul 2022
Topic Review
Aurora Kinases in Lung Cancer
Lung cancer has remained one of the major causes of death worldwide. Thus, a more effective treatment approach is essential such as the inhibition of specific cancer-promoting molecules. Aurora kinases regulate the process of mitosis - a process of cell division that is necessary for normal cell proliferation. However, dysfunction of these kinases can contribute to cancer formation. The aberrant expression of Aurora kinases in lung cancer points to their crucial role in lung carcinogenesis. Therefore, understanding the fundamental functions as well as the cellular localization of Aurora kinases may contribute to evaluate their precise oncogenic function that will may lead to better specific targeting of these cancer-related molecules.  
  • 1.0K
  • 07 Jul 2021
Topic Review
Cobalt–Chromium Dental Alloys
Co–Cr dental alloys consist of Co, Cr and also other metals (e.g., gallium, iron, molybdenum, nickel, ruthenium, tungsten). Since the 1990s, regulations have emerged to protect European patients and also monitor recent scientific knowledge. The use of metals and, therefore, dental alloys has been highly regulated by directives and regulations. Europe has, therefore, developed a regulatory package to protect all players involved in alloys, whether they are metal producers, manufacturers of alloys and medical devices, healthcare professionals and patients. Objective information is provided about Co–Cr dental alloys, with regard to both the latest toxicological data and regulatory developments from 2020–2025. The release of metal ions and the problem of wear particles are also discussed. With the recent change of regulatory status of Co, it is necessary to know the many repercussions (economic, technical etc.) of their use precisely in order to then allow actors to modify their daily work. The legislative changes also bring the need to propose new alternatives to Co-Cr dental alloys.  
  • 1.0K
  • 21 Jan 2021
Topic Review
Mechanisms of Snake Venom Induced Pain
Not all venoms contain the same constituents; not all sensory neurons or other components of the nervous system are vulnerable to the same peptide or enzyme; not all tissues and organs have the same innervation or vulnerability to venom constituents; and, lastly, snakes have incredibly diverse venom proteomes, a diversity driven by geographical and other environmental factors. Documentation of specific pain syndromes in greater detail in future epidemiological studies of snake bite is also critical. 
  • 1.0K
  • 28 Mar 2022
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