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Topic Review
Ginseng against Respiratory Tract Infections
Ginseng has been reported to inhibit bacterial pathways, thereby killing bacteria indirectly. It has also been shown to protect the host from bacterial invasion.
  • 1.0K
  • 30 Sep 2021
Topic Review
Aromas Influencing the GABAergic System
Aromas have a powerful influence in people's everyday life and are known to exhibit an array of pharmacological properties, including anxiolytic, anti-stress, relaxing, and sedative effects. Numerous animal and human studies support the use of aromas and their constituents to reduce anxiety-related symptoms and/or behaviours. Although the exact mechanism of how these aromas exert their anxiolytic effects is not fully understood, the GABAergic system is thought to be primarily involved. The fragrance emitted from a number of plant essential oils has shown promise in recent studies in modulating GABAergic neurotransmission, with GABAA receptors being the primary therapeutic target. 
  • 1.0K
  • 19 Apr 2022
Topic Review
GENCODE
GENCODE is a scientific project in genome research and part of the ENCODE (ENCyclopedia Of DNA Elements) scale-up project. The GENCODE consortium was initially formed as part of the pilot phase of the ENCODE project to identify and map all protein-coding genes within the ENCODE regions (approx. 1% of Human genome). Given the initial success of the project, GENCODE now aims to build an “Encyclopedia of genes and genes variants” by identifying all gene features in the human and mouse genome using a combination of computational analysis, manual annotation, and experimental validation, and annotating all evidence-based gene features in the entire human genome at a high accuracy. The result will be a set of annotations including all protein-coding loci with alternatively transcribed variants, non-coding loci with transcript evidence, and pseudogenes.
  • 1.0K
  • 08 Nov 2022
Topic Review
Clinical Indications to Germectomy in Pediatric Dentistry
Germectomy is a procedure often required in patients at developmental age. It is defined as the surgical removal of the third molar at a very specific stage of development. 
  • 1.0K
  • 25 Jan 2022
Topic Review
AhR, inflammation and breast cancer
AhR, an environmentally sensitive transcription factor, is one of the more evolutionary conserved molecules in living cells.
  • 1.0K
  • 21 Feb 2022
Topic Review
Film-Forming Systems
Film-forming formulations represent a novel form of sustained release dermatic products. They are applied to the skin as a liquid or semi-solid preparation.
  • 1.0K
  • 30 Jun 2021
Topic Review
Accelerated Experiential Dynamic Psychotherapy
Accelerated experiential dynamic psychotherapy (AEDP) is a mind-body psychotherapy that is informed by research in the areas of attachment theory, emotion theory, and neuroscience of change. This model of psychotherapy incorporates techniques from experiential therapies (such as Gestalt therapy and person-centered therapy) and ISTDP. AEDP was initially developed as a psychotherapy to treat the effects of childhood attachment trauma and abuse. It is recognized as an effective treatment for complex post-traumatic stress disorder, and attachment disturbances in adults. It is further applied to the treatment of eating disorders, to the treatment considerations when working with diverse populations, to couples therapy, and to the treatment of dissociative disorders. AEDP is applied to the practice of psychotherapy supervision and to short-term psychotherapy.
  • 1.0K
  • 24 Nov 2022
Topic Review
Vitamin K
Vitamin K has been recognized as a key factor for the synthesis of blood clotting factors in the liver, and is currently known to be involved in a wide range of biological processes and is associated with many pathological conditions.The most well-known function of vitamin K is as a cofactor for the γ-glutamyl carboxylase (GGCX) enzyme responsible for the post-translational modification of vitamin K-dependent proteins (VKDPs) through the conversion of specific glutamic acid (Glu) into calcium binding γ-carboxyglutamic acid (Gla) residues. Vitamin K deficiency has been linked to several pathological conditions such as cardiovascular diseases (CVD), chronic kidney disease (CKD), osteoarthritis (OA) , rheumatoid arthritis (RA), osteoporosis, cancer, dementia, certain skin pathologies, functional decline, and disability.  A new concept on the involvement of vitamin K in inflammation is growing. In fact, novel roles have been disclosed for vitamin K independent of its activity as a cofactor for GGCX, such as an antioxidant, anti-inflammatory, promoter of cognition, inhibition of tumor progression, and transcriptional regulator of osteoblastic genes. A growing number of studies has raised an increasing interest on the use of vitamin K as a health promoting supplement.  Aging societies represent a major economic challenge for health care systems, and diet supplements promoting healthy aging and improving the prognosis of age-related diseases, are required to be implemented in clinical practice.This work thoroughly reviews available data regarding differences between vitamin K1 and K2, contextualized with clinical aspects of vitamin K deficiency, including their sources, functions, target activity, and involvement in age-related diseases. Processes for the chemical and biological production of vitamin K1 and K2 will be briefly addressed. Additionally, novel sources with potential biotechnological application, and new formulations to improve vitamin K absorption and bioavailability are presented.
  • 1.0K
  • 30 Oct 2020
Topic Review
Tea Resists Carcinogenesis
Tea remains one of the most prevalent beverages consumed due in part to its physiological properties. The active compounds in tea, including tea polyphenols, tea polysaccharides, L-theanine, tea pigments, caffeine and other minor composition, can directly or indirectly reduce oncogenesis and cancerometastasis. Interestingly, the different types of tea (such as unfermented green tea, partially fermented oolong tea, and fully fermented black tea or pu-erh tea) have the different anti-cancer property.
  • 1.0K
  • 13 Oct 2021
Topic Review
Endocrine Disrupting Chemicals
Endocrine-disrupting chemicals (EDCs) are exogenous substances able to mimic or to interfere with the endocrine system, thus altering key biological processes such as organ development, reproduction, immunity, metabolism and behavior. High concentrations of EDCs are found in several everyday products including plastic bottles and food containers and they could be easily absorbed by dietary intake. In recent years, considerable interest has been raised regarding the biological effects of EDCs, particularly Bisphenol A (BPA) and phthalates, on human pregnancy and fetal development. Several evidence obtained on in vitro and animal models as well as by epidemiologic and population studies strongly indicated that endocrine disruptors could negatively impact fetal and placental health by interfering with the embryonic developing epigenome, thus establishing disease paths into adulthood. Moreover, EDCs could cause and/or contribute to the onset of severe gestational conditions as Preeclampsia (PE), Fetal Growth Restriction (FGR) and gestational diabetes in pregnancy, as well as obesity, diabetes and cardiovascular complications in reproductive age. Therefore, despite contrasting data being present in the literature, endocrine disruptors must be considered as a therapeutic target. Future actions aimed at reducing or eliminating EDC exposure during the perinatal period are mandatory to guarantee pregnancy success and preserve fetal and adult health.
  • 1.0K
  • 27 Oct 2020
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