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Topic Review
CAR NK Cell Therapy for Metastatic Melanoma
Melanoma is among the most lethal forms of cancer, accounting for 80% of deaths despite comprising just 5% of skin cancer cases. Treatment options remain limited due to the genetic and epigenetic mechanisms associated with melanoma heterogeneity that underlie the rapid development of secondary drug resistance. For this reason, the development of novel treatments remains paramount to the improvement of patient outcomes. Although the advent of chimeric antigen receptor-expressing T (CAR-T) cell immunotherapies has led to many clinical successes for hematological malignancies, these treatments are limited in their utility by their immune-induced side effects and a high risk of systemic toxicities. CAR natural killer (CAR-NK) cell immunotherapies are a particularly promising alternative to CAR-T cell immunotherapies, as they offer a more favorable safety profile and have the capacity for fine-tuned cytotoxic activity. 
  • 252
  • 06 Dec 2023
Topic Review
Histopathological Markers for Therapies in Primary Cutaneous Lymphomas
Targeted (biological) therapies have become available also for primary cutaneous T-cell lymphomas (PCTCLs) including anti-CD30 (brentuximab vedotin) in mycosis fungoides, primary cutaneous anaplastic large T-cell lymphoma, lymphomatoid papulosis; anti-CCR4 (mogamulizumab) in Sezary syndrome; anti-CD123 (tagraxofusp) in blastic plasmocytoid cell neoplasm. Moreover, anti-PD1 (nivolumab), anti-PDL1 (pembrolizumab, atezolizumab), anti-CD52 (alemtuzumab), anti-KIR3DL2-CD158k (lacutamab), and anti-CD70 (cusatuzumab) have been tested or are under investigations in phase II trials. The expression of these epitopes on neoplastic cells in skin biopsies or blood samples plays a central role in the management of PCTCL patients.
  • 128
  • 06 Dec 2023
Topic Review
Anaesthesia in Veterinary Oncology
Anaesthesia plays an important role in diagnosis procedures and the treatment and pain management of oncological patients. However, studies suggest that anaesthetic drugs may increase the risk of tumour dissemination in the perioperative period by directly and indirectly suppressing the immune system, which is primarily responsible for controlling tumour growth. 
  • 232
  • 06 Dec 2023
Topic Review
Pulmonary Pathologies and Their Relationship with Circadian Cycle
The function of the circadian cycle is to determine the natural 24 h biological rhythm, which includes physiological, metabolic, and hormonal changes that occur daily in the body. This cycle is controlled by an internal biological clock that is present in the body’s tissues and helps regulate various processes such as sleeping, eating, and others. Interestingly, animal models have provided enough evidence to assume that the alteration in the circadian system leads to the appearance of numerous diseases. Alterations in breathing patterns in lung diseases can modify oxygenation and the circadian cycles; however, the response mechanisms to hypoxia and their relationship with the clock genes are not fully understood. Hypoxia is a condition in which the lack of adequate oxygenation promotes adaptation mechanisms and is related to several genes that regulate the circadian cycles, the latter because hypoxia alters the production of melatonin and brain physiology. Additionally, the lack of oxygen alters the expression of clock genes, leading to an alteration in the regularity and precision of the circadian cycle. In this sense, hypoxia is a hallmark of a wide variety of lung diseases.
  • 182
  • 06 Dec 2023
Topic Review
Percutaneous DVA (pDVA)
Percutaneous deep venous arterialization (DVA) is considered the last-chance treatment for ‘no-option’ patients with chronic limb-threatening ischemia (CLTI). Palliative amputation, which is linked to a high risk of peri-procedural and 1-year mortality, is thereby potentially avoided. Due to the lack of reproducibility and standardization of the procedure, DVA has been attempted in multiple settings using tools and techniques currently available (i.e., ‘off-label’). In studies where alternate techniques of venous arterialization have been used, technical and clinical success varied from 77% to 100% and from 29% to 75%, respectively.
  • 239
  • 06 Dec 2023
Topic Review
Oxidative Stress and Skin Cancer
Oxidative stress is caused by an imbalance between the production and subsequent accumulation of reactive oxygen species (ROS) in cells and tissues and the capacity of a biological system to eliminate these reactive substances. Systemic oxidative stress biomarkers in plasma, serum, urine, or red blood cells have been found to be elevated in many diseases, including skin cancer. UV radiation (UVR) induces damage to biomolecules that enter the bloodstream, reinforcing systemic oxidative stress. On the other hand, pre-existing systemic oxidative stress does not supply the skin with the adequate micronutrients and antioxidant resources to ameliorate the skin’s antioxidant defense against UVR. In both scenarios, skin cancer patients are exposed to oxidative conditions. In the case of warts, oxidation is linked to chronic inflammation, while impaired cutaneous antioxidant defense could ineffectively deal with possible oxidative stimuli from viral agents, such as HPV. 
  • 242
  • 06 Dec 2023
Topic Review
Ion Channel Disturbances in Migraine Headache
Migraine is a primary headache disorder, which is an enormous burden to the healthcare system. While some aspects of the pathomechanism of migraines remain unknown, the most accepted theory is that activation and sensitization of the trigeminovascular system are essential during migraine attacks. It has been suggested that ion channels may be important participants in the pathogenesis of migraine. Numerous ion channels are expressed in the peripheral and central nervous systems, including the trigeminovascular system, affecting neuron excitability, synaptic energy homeostasis, inflammatory signaling, and pain sensation. Dysfunction of ion channels could result in neuronal excitability and peripheral or central sensitization.
  • 296
  • 06 Dec 2023
Topic Review
Off-Label Prescribing in Pediatric Population
Off-label prescribing is widespread among pediatricians, and it is unlikely that this trend will soon be bound by a uniform legal framework. This is necessitated by the fact that there are four variables: the patient’s health condition, the physician’s experience and knowledge, the legislative measures (laws, directives, guidelines, and recommendations), and finally, the pharmaceutical industry. There is considerable concern worldwide about the use of off-label medicines in children. 
  • 121
  • 06 Dec 2023
Topic Review
Immunotherapies for Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is a prominent health issue with an increasing rate of worldwide occurrence. In 2020, HCC accounted for 906,000 new cases and 830,000 new deaths, making it the third greatest cause of cancer death. Liver diseases, such as cirrhosis and chronic viral hepatitis, often result in the development of inflammation, fibrosis, necrosis, and subsequent regeneration, which will injure and alter the organization of the liver tissues, contributing to HCC prognosis. The main risk factors include hepatitis C virus (HCV), hepatitis B virus (HBV), alcohol use disorder, and non-alcoholic steatohepatitis (NASH).
  • 314
  • 06 Dec 2023
Topic Review
Definitions and the Basics of Knot Tying
Surgical knots are sequences of half-knots (H) or half-hitches (S), defined by their number of throws, by an opposite or similar rotation compared with the previous one, and for half-hitches whether they are sliding (s) or blocking (b). Opposite rotation results in (more secure) symmetric (s) knots, similar rotation in asymmetric (a) knots, and changing the active and passive ends has the same effect as changing the rotation. Loop security is the force to keep tissue together after a first half-knot or sliding half-hitches. With polyfilament sutures, H2, H3, SSs, and SSsSsSs have a loop security of 10, 18, 28, and 48 Newton (N), respectively. With monofilament sutures, they are only 7, 16, 18, and 25 N. For knot security, half hitch sequences such as 2 sliding and 2 blocking half hitches are the future: the risk of destabilisation is less, and for monofilament sutures, they are mandatory.   
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  • 05 Dec 2023
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