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Topic Review
Gut Microbiome
The gut microbiome can play important role in maintaining homeostasis in the human body. An imbalance in the gut microbiome can lead to pro-inflammatory immune responses and the initiation of disease processes, including cancer. The research results prove some strains of probiotics by modulating intestinal microbiota and immune response can be used for cancer prevention or/and as adjuvant treatment during anticancer chemotherapy.
  • 1.2K
  • 15 Jan 2021
Topic Review
Sports performance and systems theories
The purpose is to present a brief idea about the understanding of sports performance through the lens of systems theories.
  • 1.2K
  • 26 Oct 2020
Topic Review
Quercetin a Natural Therapeutic Candidate
This manuscript was provided as a comprehensive review of the anti-influenza virus effect of quercetin and its derivatives with critical evaluation. We provided different classifications and focused on viral pathogenesis, animal models, human studies, in silico and docking studies and molecular pathways of quercetin and derivatives effects comprehensively which is not included in similar articles. This review is a multidisciplinary collection of cell biology, biotechnology, drug development, and virus investigation.
  • 1.2K
  • 11 Jan 2021
Topic Review
Von Willebrand Factor
The von Willebrand factor (vWF) is a plasma protein that mediates platelet adhesion and leukocyte recruitment to vascular injury sites and carries coagulation factor VIII, a building block of the intrinsic pathway of coagulation. A steep rise in shear rates, which may occur at sites of arterial stenosis and injury, is crucial for unfolding and activation of vWF. The hemostatic activity of vWF is counterbalanced by ADAMTS-13, a vWF-cleaving protease. The presence of ultra-large multimers of vWF in the bloodstream is associated with spontaneous thrombosis, whereas its deficiency leads to bleeding.
  • 1.2K
  • 12 Nov 2020
Topic Review
Neuro-Monitoring in Intravenous Anaesthesia
The monitoring of hypnosis depth by means of electroencephalogram-based (EEG-based) systems is emerging in paediatric anaesthesia common practice. This monitor system measures specific EEG signs which derive from anaesthetic-induced changes in neuronal firing.
  • 1.2K
  • 30 Jun 2021
Topic Review
Resveratrol in Autism Spectrum Disorders
Resveratrol (RSV) is a polyphenolic stillbenoid with significant anti-oxidative and anti-inflammatory properties recently tested in animal models of several neurological diseases. Altered immune alteration and oxidative stress have also been found in patients with autism spectrum disorders (ASD), and these alterations could add to the pathophysiology associated with ASD. 
  • 1.2K
  • 27 May 2021
Topic Review
Pediatric Medulloblastoma
Medulloblastoma is the most common pediatric brain tumor, comprising one-third of all pediatric brain tumors, and originating in the posterior fossa of the brain. The disease is categorized into four subtypes: WNT, Sonic hedgehog (SHH), Group 3, and Group 4. Each subtype has unique pathogenesis, biomarkers, prognosis, response to therapy, and potential for further pharmacologic investigation. 
  • 1.2K
  • 01 Sep 2022
Topic Review
Active Phosphorylated G Protein-Coupled Receptors
G-protein coupled receptors (GPCRs) are the largest known family of signaling proteins, with over 800 members in humans, and even more in most mammalian species. They are responsible for initiating intracellular signaling that affects metabolism, growth, differentiation, and mediate sensory inputs underlying taste, sense of smell, and vision. GPCRs are targeted by about a third of clinically used drugs.
  • 1.1K
  • 25 Nov 2021
Topic Review
Nanomedicine in NSCLC
The hard diagnosis and treatment of NSCLC, together with its late diagnosis and lack of therapies during the early stages of the disease,  so far explain its high mortality rate. The reformulation of conventional therapies as nanomedicines, has led to a new generation of treatments for NSCLC. However, the deepening of the relationship between the tumor and the patient's immune system encompasses the most promising strategies today. From immune checkpoint inhibitors, identified in 2018, to the development of vaccines based on genetic material, immunotherapies represent the best of options. The use of nanometric vehicles for the release of genetic material, protein or drug allows reducing doses and increasing efficiency. These, together with delivery systems based on nanomedicines, promise to increase the specificity and efficacy of treatments, reducing the extremely harmful side effects of conventional therapies. Non-small cell lung cancer (NSCLC) remains the most common cause of cancer-related mortality. The heterogeneous nature of this disease hinders its diagnosis and treatment, requiring continuous advances in research aiming to understand its intricate nature. Consequently, the retrospective analysis of conventional therapies has allowed the introduction of novel tools provided by nanotechnology, leading to considerable improvements in clinical outcomes. Furthermore, the development of novel immunotherapies based on the recently understood interaction of the immune system with the tumor highlights the real possibility of definitively treating NSCLC from its early stages. Novel engineering approaches in nanomedicine will enable to overcome the intrinsic limits of conventional and emerging therapies regarding off-site cytotoxicity, specificity, resistance mechanisms, and administration issues. The convergence point of these therapies with nanotechnology lays the foundation for achieving currently unmet needs.
  • 1.1K
  • 17 Sep 2020
Topic Review
Tryptophan Metabolic Pathways in Migraine-Related Mechanisms
Migraine is a complex neurovascular disorder, which causes intense socioeconomic problems worldwide. The pathophysiology of disease is enigmatic; accordingly, therapy is not sufficient. Migraine research focused on tryptophan, which is metabolized via two main pathways, the serotonin and kynurenine pathways. Both produce neuroactive molecules that influence pain processing and stress response by disturbing neural and brain hypersensitivity and interacting with molecules that control vascular and inflammatory actions. Serotonin has a role in trigeminal pain processing, and melatonin, another product of this pathway, also has a role in these processes. One of the end products of the kynurenine pathway is kynurenic acid (KYNA), which can decrease the overexpression of migraine-related neuropeptides in experimental conditions. However, the ability of KYNA to cross the blood-brain barrier is minimal, necessitating the development of synthetic analogs with potentially better pharmacokinetic properties to exploit its therapeutic potential.
  • 1.1K
  • 05 Dec 2022
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