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Topic Review
Tooth Diversity
Although the evolution of tooth structure seems highly conserved, remarkable diversity exists among species due to different living environments and survival requirements. Along with the conservation, this diversity of evolution allows for the optimized structures and functions of teeth under various service conditions, providing valuable resources for the rational design of biomimetic materials. 
  • 527
  • 03 Feb 2023
Topic Review
Tools to Monitor Neuromuscular Fatigue
Neuromuscular fatigue (NMF) is a reduction in the maximal voluntary force induced by exercise, with neuromuscular function changes that are due to repeated or sustained muscular contraction, and that are produced either at the peripheral or central levels, and that can be detected for upwards of 48 h to an extended period. An accumulation of work or an incomplete force restoration can significantly influence the neuromuscular performance in both the short and long terms. Thus, fatigue management is essential for controlling the training adaptations of athletes and reducing their susceptibility to injury and illness. The main individualized monitoring tools used to describe fatigue are questionnaires and subjective assessments of fatigue, biochemical markers, sprint tests, and vertical jump tests. Among the subjective measures, the rating of the perceived exertion has been widely used because of its simplicity and high validity. In terms of the objective measures, one of the more frequently employed tools by practitioners to assess neuromuscular fatigue is the countermovement jump. Because of its high validity and reliability, it is accepted as the reference standard test in sports, in general, and particularly in team sports. 
  • 1.4K
  • 05 May 2022
Topic Review
Tools for Molecular Epidemiology of Streptococcus suis
Streptococcus suis is a pathogen of pigs that can cause infections in humans who are in close contact with infected animals and/or contaminated pork-derived products, as well as those who have consumed raw pork products. Several molecular methods have been applied to investigate S. suis strain diversity and identify phylogenetic groups. Multilocus sequence typing (MLST), commonly used to differentiate between S. suis strains, has been instrumental in identifying that the species is genetically highly diverse. Recent advances in whole-genome analysis have resulted in schemes permitting the classification of S. suis populations as pathogenic or non-pathogenic, or disease-associated or non-disease associated. 
  • 349
  • 10 Feb 2022
Topic Review
Tools and Methods for Diagnosing Developmental Dysgraphia
Handwriting is a complex perceptual motor task that requires years of training and practice before complete mastery. Its acquisition is crucial, since handwriting is the basis, together with reading, of the acquisition of higher-level skills such as spelling, grammar, syntax, and text composition. Despite the correct learning and practice of handwriting, some children never master this skill to a sufficient level. These handwriting deficits, referred to as developmental dysgraphia, can seriously impact the acquisition of other skills and thus the academic success of the child if they are not diagnosed and handled early.
  • 131
  • 25 Dec 2023
Topic Review
Tonsillolith
Tonsilloliths, also known as tonsil stones, are soft aggregates of bacterial and cellular debris that form in the tonsillar crypts, the crevices of the tonsils. While they occur most commonly in the palatine tonsils, they may also occur in the lingual tonsils. Tonsil stones are common. Tonsilloliths have been recorded weighing from 0.3 g to 42 g. Protruding tonsilloliths may feel like foreign objects lodged in the tonsil crypt. They may be a nuisance and difficult to remove, but are usually not harmful. They are one of the causes of bad breath and always give off a putrid smell.
  • 894
  • 11 Nov 2022
Topic Review
Tongue and Systemic Connections Microbiota
The tongue is able to quickly reflect the state of health or disease of the human body. Tongue inspection is an important diagnostic approach. It is a unique method that allows to explore the pathogenesis of diseases based on the guiding principles of the holistic concept that involves the observation of changes in the lining of the tongue in order to understand the physiological functions and pathological changes of the body. It is a potential method of screening and early detection of cancer.
  • 1.4K
  • 07 Jul 2021
Topic Review
Tomato and Olive Oil in Prostate Health
Tomato, the fruit providing the most comprehensive complex of prostate-health-preserving micronutrients, has been shown to be superior to its single-nutrient counterparts in decreasing the incidence of age-related prostate diseases.
  • 1.7K
  • 30 Mar 2023
Topic Review
Toll-like Receptors in Hematology
Toll-like receptors (TLR) belong to the pattern recognition receptors (PRR). TLRs are primarily expressed in hematopoietic cells. TLRs also direct the formation of blood cellular components and make a contribution to the pathogenesis of certain hematopoietic malignancies. 
  • 261
  • 22 May 2023
Topic Review
Toll-Like Receptors in Essential Hypertension
Essential hypertension (EH) is a highly heterogenous disease with a complex etiology. Toll-like receptors (TLRs) have been implied as novel effectors in this inflammatory environment since they can significantly stimulate the production of pro-inflammatory cytokines, the migration and proliferation of smooth muscle cells and the generation of reactive oxygen species (ROS), facilitating a low-intensity inflammatory background that is evident from the very early stages of hypertension. Furthermore, the net result of their activation is oxidative stress, endothelial dysfunction, vascular remodeling, and finally, vascular target organ damage, which forms the pathogenetic basis of EH. Importantly, evidence of augmented TLR expression and activation in hypertension has been documented not only in immune but also in several non-immune cells located in the central nervous system, the kidneys, and the vasculature which form the pathogenetic core systems operating in hypertensive disease.
  • 521
  • 18 May 2021
Topic Review
Toll-like Receptors in Cancers
Toll-like receptors (TLRs) represent a family of pattern recognition receptors that recognize certain pathogen-associated molecular patterns and damage-associated molecular patterns. TLRs are highly interesting to researchers including immunologists because of the involvement in various diseases including cancers, allergies, autoimmunity, infections, and inflammation. After ligand engagement, TLRs trigger multiple signaling pathways involving nuclear factor-κB (NF-κB), interferon-regulatory factors (IRFs), and mitogen-activated protein kinases (MAPKs) for the production of various cytokines that play an important role in diseases like cancer. TLR activation in immune as well as cancer cells may prevent the formation and growth of a tumor. Nonetheless, under certain conditions, either hyperactivation or hypoactivation of TLRs supports the survival and metastasis of a tumor. Therefore, the design of TLR-targeting agonists as well as antagonists is a promising immunotherapeutic approach to cancer.
  • 630
  • 26 Jun 2021
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