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Topic Review
Silphium
The chemical composition of three Silphium species in the aspect of the possibility of their use for various purposes has been evaluated. The plant material of three Silphium species (S. perfoliatum, S. trifoliatum and S. integrifolium) was acquired from cultivation located in eastern Poland. The vegetative propagating material consisted of seeds and rhizomes. Content of protein (up to 22.9% in leaves of S. perfoliatum), amino acids (aspartic acid—up to 12.0%, glutamic acid—up to 9.5%, and leucine—up to 9.4%), fat (up to 4.2% in inflorescences of S. perfoliatum), cellulose (up to 42.9% in stems of S. trifoliatum), water-soluble sugars (up to 26.7% in rhizomes of S. perfoliatum) and mineral substances (ash up to 20.9% in stems of S. integrifolium, with significant levels of elements such as K, Ca, Mg, Fe, Mn) in the tested Silphium species can be an important criterion determining a positive evaluation of these plants as sources of alternative raw materials. The conducted research is meant to draw attention to the possibility of use of the biomass of three Silphium species as a potential source of ecological and renewable raw material for food, pharmaceuticals, feed and possibly also for energy generation purposes.
  • 1.7K
  • 02 Nov 2020
Topic Review
Myrica esculenta
Myrica esculenta (Myricaceae) is a popular medicinal plant most commonly found in the sub-tropical Himalayas. It is widely used in folk medicine to treat several ailments such as asthma, cough, chronic bronchitis, ulcers, inflammation, anemia, fever, diarrhea, and ear, nose, and throat disorders. Due to its multidimensional pharmacological and therapeutic effects, it is well recognized in the ayurvedic pharmacopeia.
  • 1.7K
  • 19 Apr 2022
Topic Review
Biosurfactants Properties
Biosurfactants (BSs) are emerging surface-active molecules with high potential for a wide range of applications in the biomedical and pharmaceutical fields. BSs are extremely attractive due to their significant antimicrobial (against bacteria, fungi and viruses), antiadhesive and biofilm disruptive properties. Their use, either on their own or in combination with other antimicrobial or chemotherapeutic drugs, might pave the way for a future strategy of prevention and counteraction of microbial infections, biofilm formation and proliferation. In addition, BSs have recently attracted the attention of the scientific community as a new potential generation of pharmaceutics to be included in anticancer, immunomodulatory, wound healing, cosmetic and drug delivery agents.
  • 1.7K
  • 11 May 2021
Topic Review
Conventional Liposomal Formulation Methods
Liposome-based drug delivery systems are nanosized spherical lipid bilayer carriers that can encapsulate a broad range of small drug molecules (hydrophilic and hydrophobic drugs) and large drug molecules (peptides, proteins, and nucleic acids). They have unique characteristics, such as a self-assembling bilayer vesicular structure. There are various methods used in the preparation of lipid-based nanocarriers such as liposomes. The method of preparation affects critical parameters such as size of vesicle and size distribution, permeability, lamellarity, and entrapment efficiency. Entrapment of compounds is performed by two main techniques; passive loading where drug entrapment occurs during the liposome formation, and active loading where drug entrapment is after the liposome formation.
  • 1.7K
  • 15 May 2023
Topic Review
Entoptic Phenomenon
Entoptic phenomena (from grc ἐντός (entós) 'within', and ὀπτικός (optikós) 'visual') are visual effects whose source is within the human eye itself. (Occasionally, these are called entopic phenomena, which is probably a typographical mistake.) In Helmholtz's words: "Under suitable conditions light falling on the eye may render visible certain objects within the eye itself. These perceptions are called entoptical."
  • 1.7K
  • 02 Nov 2022
Topic Review
Timeline of Malaria
Malaria is an infectious disease caused by a parasite; it is spread by the bite of an infected mosquito. Every year, 300 to 700 million people get infected. Malaria kills 1 million to 2 million people every year. 90% of the deaths occur in Africa.
  • 1.7K
  • 31 Oct 2022
Topic Review
Glutathione and Cardiovascular Diseases
Cardiovascular diseases such as coronary artery occlusion, hypertensive heart disease and stroke, high blood pressure, myocardial infarction, cerebrovascular disease, heart failure, rheumatic heart disease, congenital heart disease and cardiomyopathies generate thousands of patients with high mortality and morbidity worldwide. The appearance of these diseases increases with the aging of the population. In addition, these diseases are complicated by some comorbidity that patients present (overweight, obesity, diabetes mellitus, etc.). The installation and development of these diseases are closely linked to metabolic changes that generate a state of oxidative stress, due to the excessive production of reactive oxygen species (ROS) and reactive nitrogen species (RNS).
  • 1.7K
  • 09 Aug 2021
Topic Review
Fungal Dermatitis
Fungal infections are potentially zoonotic and represent challenging cases to accurately diagnose. The current study documents a rare case of Geotrichum candidum dermatomycosis in a horse, which caused chronic skin disease and significant morbidity, partly attributed to incorrect clinical management. 
  • 1.7K
  • 28 Oct 2020
Topic Review
Mangiferin
Mangiferin is a naturally occurring C-glucosylxantone that has substantial potential for the treatment of various diseases. It possesses antioxidant, anti-infection, anti-cancer, anti-diabetic, cardiovascular, neuroprotective properties and it also increases immunity.
  • 1.7K
  • 10 Jan 2022
Topic Review
STAT3 and p53
The tumor suppressor p53 is considered the “guardian of the genome” that can protect cells against cancer by inducing cell cycle arrest followed by cell death. However, STAT3 is constitutively activated in several human cancers and plays crucial roles in promoting cancer cell proliferation and survival. Hence, STAT3 and p53 have opposing roles in cellular pathway regulation, as activation of STAT3 upregulates the survival pathway, whereas p53 triggers the apoptotic pathway. Constitutive activation of STAT3 and gain or loss of p53 function due to mutations are the most frequent events in numerous cancer types. Several studies have reported the association of STAT3 and/or p53 mutations with drug resistance in cancer treatment. This review discusses the relationship between STAT3 and p53 status in cancer, the molecular mechanism underlying the negative regulation of p53 by STAT3, and vice versa. Moreover, it underlines prospective therapies targeting both STAT3 and p53 to enhance chemotherapeutic outcomes.
  • 1.7K
  • 12 Jan 2021
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