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Topic Review
Vaccination Recommendations for Patients with Systemic Sclerosis
Systemic sclerosis (SSc) is a rare autoimmune inflammatory rheumatic disease. Vaccines represent one of the safest and most effective means of disease control. 
  • 695
  • 14 Dec 2021
Topic Review
Vaccination Hesitancy
Vaccines are an important tool of preventive medicine. Although organized vaccination programs have saved large populations from serious infectious diseases, there is a considerable part of the population who oppose vaccinations. In particular, anti-vaccination perceptions, among travelers to countries with endemic diseases, are a major public health concern.
  • 210
  • 17 Oct 2023
Topic Review
Vaccination and Religion
Vaccination and religion have interrelations of varying kinds. Almost no religions object to vaccination, and some parents either fake religious adherence or invent fake religions to provide exemption.
  • 389
  • 03 Nov 2022
Topic Review
VA ECMO use in Pediatric
In children with severe advanced heart failure where medical management has failed, mechanical circulatory support in the form of veno-arterial extracorporeal membrane oxygenation (VA ECMO) or ventricular assist device represents life-sustaining therapy.The two primary forms of mechanical circulatory support are veno-arterial extracorporeal membrane oxygenation (VA ECMO) and ventricular assist devices (VAD). The two technologies have unique advantages and disadvantages and could be considered as complementary devices and, at times, used in sequence as the clinical scenario dictates.
  • 543
  • 05 May 2021
Topic Review
Uveal Melanomas
Traditionally, it has been thought that metastatic spread in uveal melanoma (UM) and dissemination occurs prior to presentation and that treatment of the primary tumor does not change outcome. However, it seems as though small UM tumours can not only be lethal with high risk monosomy 3 mutations, treated at an earlier time point at a smaller stage seems to improve mortality outcomes. 
  • 446
  • 22 Sep 2021
Topic Review
Uveal Melanoma Tumors
Uveal melanoma (UM), a rare form of melanoma, is the most common intraocular cancer in adults.
  • 491
  • 26 Oct 2021
Topic Review
UVA-Degradable Collagenase Nanocapsules
Peyronie and Dupuytren are pathologies characterized by the appearance of localized fibrotic lesions in an organ. These disorders originate from an excessive production of collagen in the tissue provoking dysfunction and functional limitations to the patients. Local administration of collagenase is the most used treatment for these fibrotic-type diseases, but a high lability of the enzyme limits its therapeutic efficacy. Herein, we present a novel methodology for the preparation of collagenase nanocapsules without affecting its enzymatic activity and capable of releasing the enzyme in response to an ultraviolet A (UVA) light stimulus.
  • 325
  • 18 May 2021
Topic Review
UV Radiation in DNA Damage and Repair
Prolonged exposure to ultraviolet radiation on human skin can lead to mutations in DNA, photoaging, suppression of the immune system, and other damage up to skin cancer (melanoma, basal cell, and squamous cell carcinoma).
  • 2.0K
  • 27 Dec 2021
Topic Review
UV Filters
The use of sunscreens is a recommended practice to protect skin from solar-induced damage. Around 30 UV filters can be used in sunscreen products in the European Union. However, low photostability and putative toxicity for humans and environment have been reported for some UV filters. Therefore, it is important to develop new UV filters with improved safety profile and photostability. Over the last two decades, nearly 200 new compounds have revealed promising photoprotection properties. The explored compounds were obtained through different approaches, including exploration of natural sources, synthetic pathways, and nanotechnology. Almost 50 natural products and around 140 synthetic derivatives have been studied aiming the discovery of novel, effective, and safer future photoprotective agents. 
  • 1.5K
  • 05 May 2022
Topic Review
Utilizing Cytomegalovirus T Cells in Adoptive Cell Therapy
Infection with cytomegalovirus (CMV) is highly prevalent in the general population and largely controlled by CD8pos T cells. Intriguingly, anti-CMV T cells accumulate over time to extraordinarily high numbers, are frequently present as tumor-resident ‘bystander’ T cells, and remain functional in cancer patients. Consequently, various strategies for redirecting anti-CMV CD8pos T cells to eliminate cancer cells are currently being developed. This includes conveying the advantageous characteristics of anti-CMV T cells in adoptive cell therapy. Chimeric antigen receptors (CARs) and T cell receptors (TCRs) were transduced into anti-CMV CD8pos T cells to improve the in vivo persistence of CAR/TCR-engineered T cells. Moreover, anti-CMV T cells were activated ex vivo, expanded, and reinfused into glioblastoma patients to directly target CMV peptide epitopes expressed in a subset of glioblastomas.
  • 276
  • 14 Aug 2023
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