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Topic Review
Acute Exercise and Your Brain
While the physical improvements from exercise have been well documented over the years, the impact of physical activity on mental health has recently become an object of interest. Physical exercise improves cognition, particularly attention, memory, and executive functions. However, the mechanisms underlying these effects have yet to be fully understood. 
  • 271
  • 07 Jul 2023
Topic Review
Secondary Osteoporosis in Vulnerable Children
By definition, children constitute a vulnerable population, especially when they are chronically ill and/or disabled. A characteristic of chronically ill and disabled children is that they also suffer from indirect effects of their disease, such as immobilization, chronic inflammation, reduced time outdoors in the sun, osteotoxic effects of disease-targeted therapy (like glucocorticoids), and poor nutrition. All these factors may lead to bone fragility due to secondary osteoporosis, a co-morbidity that may be overlooked in the context of serious underlying diseases. 
  • 342
  • 07 Jul 2023
Topic Review
Characterization of Semi-Solid Formulations
Specific aspects of semi-solid dosage forms for topical application include the nature of the barrier to be overcome, aspects of susceptibility to physical and chemical instability, and a greater influence of sensory perception. Advances in understanding the driving forces of skin penetration as well as the design principles and inner structure of formulations, provide a good basis for the more rational design of such dosage forms, which still often follow more traditional design approaches. The characterization of semi-solid dosage forms also requires specific approaches. In particular, rheology, chemical stability considering the specifics of semi-solid vehicles, and in vitro performance testing will be discussed.
  • 605
  • 07 Jul 2023
Topic Review
miRNAs in RA Development
Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease characterized by autoimmunity, synovial inflammation and joint destruction. Pannus formation in the synovial cavity can cause irreversible damage to the joint and cartilage and eventually permanent disability. 
  • 289
  • 07 Jul 2023
Topic Review
Transcatheter Tricuspid Valve Interventions
Tricuspid regurgitation (TR) is a common valvular pathology, estimated to affect 1.6 million people in the United States alone. Even though guidelines recommend either medical therapy or surgical treatment for TR, the misconception of TR as a benign disease along with the high mortality rates of surgical intervention led to undertreating this disease and commonly describing it as a “forgotten” valve.
  • 517
  • 07 Jul 2023
Topic Review
Imaging of Skull Base Tumors
The skull base provides a platform for supporting the brain while serving as a conduit for major neurovascular structures. In addition to malignant lesions originating in the skull base, there are many benign entities and developmental variants that may simulate disease. Therefore, a basic understanding of the relevant embryology is essential. Lesions centered in the skull base can extend to the adjacent intracranial and extracranial compartments; conversely, the skull base can be secondarily involved by primary extracranial and intracranial disease. Computed tomography (CT) and magnetic resonance imaging (MRI) are the mainstay imaging methods and are complementary in the evaluation of skull base lesions. 
  • 284
  • 07 Jul 2023
Topic Review
Myeloid Leukemia of Down Syndrome
Myeloid leukemia of Down syndrome (ML-DS) is characterized by a distinct natural history and is classified by the World Health Organization (WHO) as an independent entity, occurring with unique clinical and molecular features. The presence of a long preleukemic, myelodysplastic phase, called transient abnormal myelopoiesis (TAM), precedes the initiation of ML-DS and is defined by unusual chromosomal findings.
  • 293
  • 07 Jul 2023
Topic Review
Practical Considerations for Next-Generation Adjuvant Development and Translation
Throughout the last two decades, there has been increasing focus on the discovery and translation of new immune-stimulating agents. These compounds are often collectively referred to as adjuvants due to their precedent of use in vaccine development. There has been an expansion in the application of adjuvants in oncology and other areas as the understanding and definition of adjuvants continue to grow. Adjuvants stimulate key cell types in the innate immune system and can influence the scale and class of immune response directed towards a given antigen or antigens.
  • 532
  • 07 Jul 2023
Topic Review
Antibody–Drug Conjugates for Non-Oncological Applications
Typically, antibody–drug conjugates (ADCs) are made up of a humanized antibody and a small-molecule medication connected by a chemical linker. ADCs’ ability to deliver cytotoxic agents to the specific site with reduced side effects showed promising results in oncology. Inspired by these outcomes, scientists explored the potential of antibody–drug conjugates in non-oncological conditions such as arthritis, myasthenia gravis, immunological disorders, and kidney failure. 
  • 704
  • 07 Jul 2023
Topic Review
Acute Lymphoblastic Leukemia Immunotherapy Treatment
Acute lymphoblastic leukemia (ALL) is a blood cancer that primarily affects children but also adults. It is due to the malignant proliferation of lymphoid precursor cells that invade the bone marrow and can spread to extramedullary sites. ALL is divided into B cell (85%) and T cell lineages (10 to 15%); rare cases are associated with the natural killer (NK) cell lineage (<1%). To date, the survival rate in children with ALL is excellent while in adults continues to be poor. Despite the therapeutic progress, there are subsets of patients that still have high relapse rates after chemotherapy or hematopoietic stem cell transplantation (HSCT) and an unsatisfactory cure rate. Hence, the identification of more effective and safer therapy choices represents a primary issue.
  • 326
  • 07 Jul 2023
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