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Topic Review
Contemporary Biomarkers for Renal Transplantation
Renal transplantation (RT) is the preferred treatment for end-stage renal disease. However, clinical challenges persist, i.e., early detection of graft dysfunction, timely identification of rejection episodes, personalization of immunosuppressive therapy, and prediction of long-term graft survival. Biomarkers have emerged as valuable tools to address these challenges and revolutionize RT patient care. 
  • 485
  • 09 Aug 2023
Topic Review
PSMA-PET Imaging in Prostate Cancer
There has been remarkable development in “theranostics”, in which antibodies or small molecular compounds that bind to prostate-specific membrane antigen (PSMA) are coupled with the diagnostic emitter or therapeutic alpha- or beta-emitters to diagnose or treat prostate cancer, respectively.
  • 254
  • 09 Aug 2023
Topic Review
Limitations of Non-Invasive Prenatal Testing
Prenatal genetic screening tests are ”non-invasive” methods that include the maternal serum screening of markers related to aneuploidy with or without nuchal translucency ultrasonography, and cell-free DNA screening, known as non-invasive prenatal testing (NIPT). These tests are performed by drawing maternal peripheral blood sampling; therefore, there is no risk of procedure-related pregnancy complications.
  • 379
  • 09 Aug 2023
Topic Review
Symptoms and Neurological Manifestations among COVID-19 Patients
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a newly emerged coronavirus, has sparked a global pandemic with its airborne transmission and ability to infect with asymptomatic patients. The disease state, including its pneumonia-like symptoms, is called COVID-19, as it was a coronavirus discovered in 2019. The pathophysiology is thought to relate to the binding of angiotensin converting enzyme 2 (ACE2) receptors in the body. These receptors are widely expressed in various body organs such as the lungs, the heart, the gastrointestinal tract (GIT), and the brain.
  • 252
  • 09 Aug 2023
Topic Review
Various Antibiotic Interactions with Warfarin
Warfarin is the most widely used oral anticoagulant in North America and in the world. It has a long-established efficacy for the prevention of thromboembolic events in patients with cardiovascular risk factors such as chronic atrial fibrillation, prosthetic heart valves, venous thromboembolism, and coronary artery disease. 
  • 259
  • 09 Aug 2023
Topic Review
Radiotherapy in Breast Cancer-Induced Cardiovascular Toxicity
The number of patients diagnosed with breast cancer and cardiovascular disease is continuously rising. Treatment options for breast cancer have greatly evolved, but radiotherapy (RT) still has a key role in it. Despite many advances in RT techniques, cardiotoxicity is one of the most important side effects. 
  • 257
  • 09 Aug 2023
Topic Review
The Molecular Mechanisms of Anti-Obesity Medicinal Plants
Inflammation is a crucial factor in the development and progression of cardiovascular diseases (CVD). Cardiac remodeling in the presence of persistent inflammation leads to myocardial fibrosis and extracellular matrix changes, which reduce cardiac function, induce arrhythmias, and finally, cause heart failure. Medicinal plants and phytochemicals can cure and prevent obesity and inflammation. In comparison to conventional therapies, the synergistic effects of several phytochemicals boost their bioavailability and impact numerous cellular and molecular targets.
  • 210
  • 09 Aug 2023
Topic Review
Anticancer Activity of Napabucasin
Napabucasin (also known as BBI608) is a natural naphthoquinone originally identified as a cancer cell stemness inhibitor. Accumulated in vitro and in vivo evidence demonstrated that napabucasin showed significant anticancer effects in various types of cancers. Napabucasin showed multiple anticancer activities, including proliferation inhibition, cell death induction, cell cycle arrest, metastasis suppression, drug resistance overcoming, and stemness inhibition, etc., which were documented in many benchworks.
  • 275
  • 09 Aug 2023
Topic Review
Cyclodextrins and Their Derivatives as Drug Stability Modifiers
Cyclodextrins (CDs) are versatile excipients that are widely used in the pharmaceutical industry as receptor molecules to form complexes with drugs. CDs are cyclic oligosaccharides composed of α-1,4-linked D-glucopyranoside subunits obtained through enzymatic starch degradation.
  • 215
  • 09 Aug 2023
Topic Review
Angiotensin Regulation of Vascular Homeostasis
Extensive research has been conducted to elucidate and substantiate the crucial role of the Renin-Angiotensin System (RAS) in the pathogenesis of hypertension, cardiovascular disorders, and renal diseases. Furthermore, the role of oxidative stress in maintaining vascular balance has been well established. It has been observed that many of the cellular effects induced by Angiotensin II (Ang II) are facilitated by reactive oxygen species (ROS) produced by nicotinamide adenine dinucleotide phosphate (NADPH) oxidase.
  • 193
  • 09 Aug 2023
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