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Topic Review
Physiology of Ischemia and Reperfusion Injury for Transplantation
Cold preservation is a key component to organ procurement and transplantation. Cold preservation functions by slowing metabolic activity of procured organs and begins the period known as cold ischemic time (CIT). Reducing CIT and warm ischemic time (WIT) are paramount to minimizing donor organ damage from ischemia and the build-up of waste products and signals that drive reperfusion injury prior to transplantation into a matching recipient.
  • 155
  • 17 Aug 2023
Topic Review
The Pathophysiology of Diabetes
Diabetes mellitus (DM) comprises a range of metabolic disorders characterized by high blood glucose levels caused by defects in insulin release, insulin action, or both. DM is a widespread condition that affects a substantial portion of the global population, causing high morbidity and mortality rates. The main symptoms of diabetes include increased blood glucose, excessive thirst, frequent urination, impaired vision, hyperphagia, weight loss, nausea, and vomiting.
  • 489
  • 17 Aug 2023
Topic Review
Different Concepts of Model of Tumour Microenvironment
With reference to cancer research, there can be ambiguity for what is meant by the word “model”. A review of different “models” of the tumour microenvironment is presented herein, as grouped by different definitions of the word into four categories: model organisms, in vitro models, mathematical models and computational models. 
  • 221
  • 17 Aug 2023
Topic Review
Diagnosis and Treatment of Fistulae
Gynecological fistulae are a rare but severe complication of radiation therapy, pelvic surgery, prolonged labor, cesarean deliveries, or inflammatory bowel diseases. A gynecological fistula is an abnormal pathway formed between the urinary and gynecological tract, most commonly located between the urinary bladder and vagina. Vesico-uterine and vesicovaginal fistulae are an important health issue, common in women of reproductive age in developing countries with limited access to obstetrical care. Various surgical techniques have been described for vesicovaginal fistula (VVF) repair, depending on the location, severity, and cause of the fistula and the surgeon’s experience.
  • 238
  • 17 Aug 2023
Topic Review
Application of Pupillometry in Neurocritical Patients
Pupillary light reflex (PLR) assessment is a crucial examination for evaluating brainstem function, particularly in patients with acute brain injury and neurosurgical conditions. The PLR is controlled by neural pathways modulated by both the sympathetic and parasympathetic nervous systems. Altered PLR is a strong predictor of adverse outcomes after traumatic and ischemic brain injuries. However, the assessment of PLR needs to take many factors into account since it can be modulated by various medications, alcohol consumption, and neurodegenerative diseases. The development of devices capable of measuring pupil size and assessing PLR quantitatively has revolutionized the non-invasive neurological examination. Automated pupillometry, which is more accurate and precise, is widely used in diverse clinical situations. 
  • 251
  • 17 Aug 2023
Topic Review
History of Preoperative Planning for Breast Reconstruction
Breast reconstruction is an essential component in the multidisciplinary management of breast cancer patients. Over the years, preoperative planning has played a pivotal role in assisting surgeons in planning operative decisions prior to the day of surgery. The evolution of preoperative planning can be traced back to the introduction of modalities such as ultrasound and colour duplex ultrasonography, enabling surgeons to evaluate the donor site’s vasculature and thereby plan operations more accurately. However, the limitations of these techniques paved the way for the implementation of modern three-dimensional imaging technologies. With the advancements in 3D imaging, including computed tomography and magnetic resonance imaging, surgeons gained the ability to obtain detailed anatomical information. Moreover, numerous adjuncts have been developed to aid in the planning process. The integration of 3D-printing technologies has made significant contributions, enabling surgeons to create complex haptic models of the underlying anatomy. Direct infrared thermography provides a non-invasive, visual assessment of abdominal wall vascular physiology. Additionally, augmented reality technologies are poised to reshape surgical planning by providing an immersive and interactive environment for surgeons to visualize and manipulate 3D reconstructions. Still, the future of preoperative planning in breast reconstruction holds immense promise. 
  • 280
  • 17 Aug 2023
Topic Review
Temporomandibular Joint Disorder Epidemiology
Temporomandibular disorders of all varieties affect people in every culture on every continent, affecting up to 11% of children and even as high as 31% of adults.
  • 282
  • 17 Aug 2023
Topic Review
Applications of Nasal Nitric Oxide in Allergic Rhinitis
Allergic rhinitis, a common allergic disease affecting a significant number of individuals worldwide, is observed in 25% of children and 40% of adults, with its highest occurrence between the ages of 20 and 40. Its pathogenesis, like other allergic diseases, involves innate and adaptive immune responses, characterized by immunologic hypersensitivity to environmental substances.
  • 203
  • 17 Aug 2023
Topic Review
Ultrasound Assessment of Calcified Arteries for Arteriovenous Fistula
Arterial calcifications are present in about 20% of patients with end-stage kidney disease and they reduce the possibility of arterio-venous fistula (AVF) formation and maturation and increase the likelihood of distal ischemia. Arterial assessment is of utmost importance if researchers are to create distal radiocephalic AVFs in the elderly patients whenever possible without burdening them with futile surgical attempts. A grading system is proposed for quantifying the severity of calcifications in the arteries of the arm with ultrasound exam.
  • 325
  • 16 Aug 2023
Topic Review
The Pharmacological of Tectorigenin
Tectorigenin is a well-known natural flavonoid aglycone and an active component that exists in numerous plants. Growing evidence suggests that tectorigenin has multiple pharmacological effects, such as anticancer, antidiabetic, hepatoprotective, anti-inflammatory, antioxidative, antimicrobial, cardioprotective, and neuroprotective. These pharmacological properties provide the basis for the treatment of many kinds of illnesses, including several types of cancer, diabetes, hepatic fibrosis, osteoarthritis, Alzheimer’s disease, etc.
  • 241
  • 16 Aug 2023
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