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Topic Review
Cell Adhesion and Migration in Regenerative Medicine
Cell adhesion and migration is essential for cell survival, communication, and regulation, and it is of fundamental importance in the development and maintenance of tissues. Cell adhesion has been widely explored due to its many important roles in the fields of tissue regenerative engineering and cell biology. With this in mind, researchers are employing novel strategies to harness the utility of cell adhesion—including the use of small molecules to promote adhesion and migration for improved tissue regeneration.
  • 358
  • 05 Oct 2023
Topic Review
Latent Tuberculosis Infection
Latent tuberculosis infection (LTBI) represents a subclinical, asymptomatic mycobacterial state affecting approximately 25% of the global population. The substantial prevalence of LTBI, combined with the risk of progressing to active tuberculosis, underscores its central role in the increasing incidence of tuberculosis (TB). Accurate identification and timely treatment are vital to contain and reduce the spread of the disease, forming a critical component of the global strategy known as “End TB.”
  • 325
  • 04 Oct 2023
Topic Review
Cerebral Vasomotor Reactivity in COVID-19
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily affects the respiratory system but can also lead to neurological complications. Among COVID-19 patients, the endothelium is considered the Achilles heel. A variety of endothelial dysfunctions may result from SARS-CoV-2 infection and subsequent endotheliitis, such as altered vascular tone, oxidative stress, and cytokine storms. The cerebral hemodynamic impairment that is caused is associated with a higher probability of severe disease and poor outcomes in patients with COVID-19.
  • 306
  • 01 Oct 2023
Topic Review
Metastatic Spinal Cord Compression in Secondary Care
Metastatic spinal cord compression (MSCC) represents an oncological emergency and clinicians should be aware of the potential long-term neurological impact. Urgent diagnosis and treatment is still challenging. Magnetic resonance imaging (MRI) of the whole spine is the imaging method of choice that should be carried out within 24 h of clinical suspicion. Steroid therapy is administered immediately after the establishment of diagnosis, followed by definitive treatment, which may include any combination of surgery and/or radiotherapy (RT). Treatment should ideally be initiated within 24 h of the confirmed MSCC. Trainees require further teaching to improve their knowledge. Equally, oncological patients should be aware of the signs and symptoms of MSCC in order to optimise early detection.
  • 289
  • 30 Sep 2023
Topic Review
Infection of Childhood Mortality in Sickle Cell Disease
Sickle cell disease (SCD) is a complex genetic disorder associated with multiple clinical manifestations, including increased susceptibility to bacterial and viral infections. 
  • 144
  • 28 Sep 2023
Topic Review
Maternal Obesity: Shaping Future Generations' Well-Being
Maternal obesity (MO) results in short- and long-term adverse outcomes for the offspring, including an increased risk for cardiovascular disease (CVD) development. Maternal obesity can have profound implications for metabolic regulation during pregnancy due to changes in glucose metabolism to support fetal growth.
  • 866
  • 28 Sep 2023
Topic Review
Pathological Protein Aggregation Involved in ALS
Amyotrophic lateral sclerosis (ALS) is a devastating progressive neurodegenerative disorder characterized by selective loss of lower and upper motor neurons (MNs) in the brain and spinal cord, resulting in paralysis and eventually death due to respiratory insufficiency. Pathological protein aggregates are also a feature of ALS, and occur in the form of ubiquitinated inclusions in neurons and glia.
  • 399
  • 28 Sep 2023
Topic Review Peer Reviewed
Diabetic Kidney Disease: Goals for Management, Prevention, and Awareness
Diabetic kidney disease (DKD), which is diagnosed on the basis of reduced glomerular filtration rate (GFR), increased albuminuria, or both, is the leading cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide. Future projections anticipate a significant increase in diabetes cases, with close to 700 million diabetes patients internationally by the year 2045. Amidst ongoing research into novel biomarkers and therapeutic agents for DKD, the current clinical preventative strategy for DKD involves (1) intensive glycemic control, (2) treatment of associated co-morbidities (hypertension and hyperlipidemia), and (3) instruction on lifestyle modifications, including smoking cessation, exercise, and dietary habits. In addition to these three categories, patient education on renal injury, a fourth category, is equally important and necessary in the collaborative effort to reduce global rates of DKD. In this entry, authors highlight and discuss these four core categories for DKD prevention.
  • 474
  • 28 Sep 2023
Topic Review
Multimodal MRI in Autism Spectrum Disorders Early Diagnosis
Autism spectrum disorder (ASD) is a neurodevelopmental disorder in children. Early diagnosis and intervention can remodel the neural structure of the brain and improve quality of life but may be inaccurate if based solely on clinical symptoms and assessment scales. Functional MRI revealed disruption of functional networks, abnormal perfusion, and neurovascular decoupling associated with core ASD symptoms. Proton magnetic resonance spectroscopy revealed abnormal changes in the neuronal metabolites during different periods. Decreased diffusion tensor imaging signals along the perivascular space index reflected impaired glymphatic system function in children with ASD. Differences in age, subtype, degree of brain damage, and remodeling in children with ASD led to heterogeneity in research results.
  • 452
  • 28 Sep 2023
Topic Review
Optical Biosensors for COVID-19 and Other Viruses Diagnosis
The sudden outbreak of the COVID-19 pandemic led to a huge concern globally because of the astounding increase in mortality rates worldwide. The medical imaging computed tomography technique, whole-genome sequencing, and electron microscopy are the methods generally used for the screening and identification of the SARS-CoV-2 virus.
  • 217
  • 28 Sep 2023
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