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Topic Review
Therapeutic Approaches for Gastric Neuroendocrine Neoplasms
Gastric neuroendocrine neoplasms (gNENs) represent rare but increasingly recognized tumors. They are distinguished into three main clinical types (type-1, type-2, and type-3) according to gastrin level and at histological evaluation in well-differentiated G1, G2, or G3 lesions, as well as poorly-differentiated lesions.
  • 342
  • 13 Oct 2023
Topic Review
Aetiology of Bicuspid Aortic Valve
BAV (Bicuspid Aortic Valve) stands as the most prevalent congenital heart condition closely linked to critical and potentially life-threatening cardiac and aortic ailments, including aortic stenosis, aortic insufficiency, aortic aneurysms, and aortic dissection. It is believed that both genetic and epigenetic factors influence the etiology of BAV. Gaining insight into this underlying causative framework is paramount in guiding treatment strategies for BAV and its associated pathologies.
  • 426
  • 12 Oct 2023
Topic Review
Medication-Overuse Headache
Medication-overuse headache (MOH) is a secondary headache that is classified by the third edition of the International Classification of Headache Disorders as a group of headaches attributable to the administration or discontinuation of various substances. MOH occurs more than 15 days per month in patients with preexisting headaches. It occurs as a result of regular (at least 3 consecutive months) overuse (10 or 15 days, depending on the type of medication) of drugs used as acute or symptomatic headache therapy.
  • 281
  • 12 Oct 2023
Topic Review
Microplastics Effects on Kidney Tissues and Cells
Microplastics (MPs) have become ubiquitous and humans are exposed daily to inhalation or ingestion of plastic microparticles. Studies performed using mainly spectroscopy or spectrometry-based techniques have shown astounding evidence for the presence of MPs in human tissues, organs and fluids. The placenta, meconium, breast milk, lung, intestine, liver, heart and cardiovascular system, blood, urine and cerebrovascular liquid are afflicted by MPs’ presence and deposition. 
  • 351
  • 12 Oct 2023
Topic Review
Astrocyte Therapy in Parkinson’s Disease
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons. While neuronal dysfunction is central to PD, astrocytes also play important roles, both positive and negative, and such roles have not yet been fully explored. 
  • 268
  • 12 Oct 2023
Topic Review
Prebiotics and Probiotics in Non-Alcoholic Fatty Liver Disease
Alterations in the gut–liver axis and changes in the gut microbiome are among the risk factors for the pathogenesis of non-alcoholic fatty liver disease (NAFLD). These patients show increased bacterial overgrowth in the small intestine and impaired intestinal permeability. Therefore, therapeutic options such as probiotics or prebiotics have been investigated to modulate intestinal microbiota composition to improve NAFLD. Most in vivo and in vitro probiotic studies have focused on reducing hepatic fat accumulation. The beneficial effects of probiotics on NAFLD have been demonstrated in animal models, and the most widely used microorganisms are those of the Lactobacillus and Bifidobacterium genera. In animal models, probiotics help restore the intestinal microbiota and improve the integrity of the intestinal barrier. 
  • 280
  • 12 Oct 2023
Topic Review
Three-Dimensional Cultures in Fungal Pathogenesis
Three-dimensional (3D) cultures are pivotal in vitro studies as an alternative model that curtails research expenses. Three-dimensional (3D) cell cultures are extensively employed for novel drug screening of antifungals. Several advantages are tied to obtaining more precise toxicity and efficacy results than in vivo models, along with host–pathogen interactions closely mimicking reality.
  • 262
  • 12 Oct 2023
Topic Review
Risk Factors of Bladder Cancer
Bladder cancer is one of the most financially burdensome cancers globally, from its diagnostic to its terminal stages. The impact it imposes on patients and the medical community is substantial, exacerbated by the absence of disease-specific characteristics and limited disease-free spans.
  • 281
  • 12 Oct 2023
Topic Review
COVID-19 and the Nervous System
Neuropsychiatric manifestations of viral infections (both per se and secondary to the neuroinflammatory reaction of the host) are mainly attributed to immunological reactions, so many aspects of their pathogenesis are still nuclear. Some novel therapeutic strategies are progressively emerging in which a vaccination may be having a particular impact on recovery and reduction of death. In this context, it is accepted that the SARS-CoV-2 virus is profoundly neurotropic and neuroinvasive, with various effects on the nervous system, although there is no complete understanding of the mechanism of neuroinvasion, brain injury, or short- or long-term neuropsychiatric sequelae.
  • 163
  • 12 Oct 2023
Topic Review
Multi-Omics in Inflammatory Bowel Disease
The notion and importance of omes, omics and multi-omics in both health and complex diseases like inflammatory bowel disease (IBD) is introduced, followed by a discussion of the various omics believed to be relevant to IBD pathogenesis, and how multi-omics “big data” can generate new insights translatable into useful clinical tools in IBD such as biomarker identification, prediction of remission and relapse, response to therapy, and precision medicine.
  • 221
  • 12 Oct 2023
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