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Topic Review
Algae Food Products as a Healthcare Solution
Diseases such as obesity; cardiovascular diseases such as high blood pressure, myocardial infarction and stroke; digestive diseases such as celiac disease; certain types of cancer and osteoporosis are related to food. On the other hand, as the world’s population increases, the ability of the current food production system to produce food consistently is at risk. As a result, intensive agriculture has contributed to climate change and a major environmental impact. Research is, therefore, needed to find new sustainable food sources. One of the most promising sources of sustainable food raw materials is macroalgae. Algae are crucial to solving this nutritional deficiency because they are abundant in bioactive substances that have been shown to combat diseases such as hyperglycemia, diabetes, obesity, metabolic disorders, neurodegenerative diseases and cardiovascular diseases. 
  • 335
  • 10 Nov 2023
Topic Review
Pain in Colorectal Surgery
Pain is a complex entity with deleterious effects on the entire organism. Poorly controlled postoperative pain impacts the patient outcome, being associated with increased morbidity, inadequate quality of life and functional recovery.
  • 187
  • 10 Nov 2023
Topic Review
Double J Stents and Reno–Ureteral Lithiasis during COVID-19
Urolithiasis, or kidney stone disease, is a common urological condition that often necessitates emergency medical attention. During the COVID-19 epidemic, significant shifts occurred in the available options for treating urinary stones. Obstructed reno–ureteral stones or infected ones should be treated as an emergency by decompression. Ureteral stents were a safe, efficient, and cost-effective procedure for urolithiasis during the COVID-19 pandemic. In addition, they reduce the risk of infection and hospital visits. Therefore, it was a valuable option in urolithiasis treatment during the pandemic.
  • 263
  • 10 Nov 2023
Topic Review
Dipeptidyl Amino-Peptidase 3 (DPP3) in Cardiogenic Shock
Dipeptidyl amino-peptidase 3 (DPP3) is an aminopeptidase that is released into circulation upon cell death. DPP3 is involved in the degradation of angiotensins, enkephalines, and endomorphines. It has been shown that circulating DPP3 (cDPP3) plasma concentration increases in cardiogenic shock (CS) patients and correlates with high mortality risk. Cardiogenic shock is a life-threatening syndrome associated with organ hypoperfusion. One of the common causes of CS is acute myocardial infarction (AMI).
  • 218
  • 10 Nov 2023
Topic Review
SRC-3 Has Multiple Roles in Breast Cancer Pathogenesis
Breast cancer (BCa) is the most frequently diagnosed malignant tumor in women and is also one of the leading causes of cancer-related death. Most breast tumors are hormone-dependent and estrogen signaling plays a critical role in promoting the survival and malignant behaviors of these cells. Estrogen signaling involves ligand-activated cytoplasmic estrogen receptors that translocate to the nucleus with various co-regulators, such as steroid receptor co-activator (SRC) family members, and bind to the promoters of target genes and regulate their expression. SRC-3 is a member of this family that interacts with, and enhances, the transcriptional activity of the ligand activated estrogen receptor. Although SRC-3 has important roles in normal homeostasis and developmental processes, it has been shown to be amplified and overexpressed in breast cancer and to promote malignancy.
  • 207
  • 09 Nov 2023
Topic Review
Dental Implants in Relation to Bone Density
Titanium has been the material of choice for dental implant fixtures due to its exceptional qualities, such as its excellent balance of rigidity and stiffness. Since zirconia is a soft-tissue-friendly material and caters to esthetic demands, it is an alternative to titanium for use in implants. Nevertheless, bone density plays a vital role in determining the material and design of implants. Compromised bone density leads to both early and late implant failures due to a lack of implant stability. 
  • 335
  • 09 Nov 2023
Topic Review
Risk of Adverse Drug Reactions in Elderly Population
The European Medicine Agency (EMA) has defined Adverse Drug Reactions (ADRs) as “a noxious and unintended response to a medicine”, not including poisoning, accidental, or intentional overdoses. The ADR occurrence differs based on the approach adopted for defining and detecting them, the characteristics of the population under study, and the research setting. ADRs have a significant impact on morbidity and mortality, particularly among older adults, and represent a financial burden for health services.
  • 304
  • 09 Nov 2023
Topic Review
Adverse Cardiovascular Effects of Radiation Therapy
Radiation therapy is a key part of treatment for many cancers. Vast advancements in the field of radiation oncology have led to a decrease in malignancy-related mortality, which has uncovered some of the long-term side effects of radiation therapy. Specifically, there has been an increase in research looking into the cardiovascular side effects of chest radiation therapy for cancers of the esophagus, breast, and lung tissue as well as lymphomas.
  • 155
  • 09 Nov 2023
Topic Review
Cryosurgery in Breast Cancer Management
Breast cancer is the most prevalent cancer and the second leading cause of death among women, primarily due to the development of deadly metastases in 25–50% of patients, resulting in an unfavorable prognosis. Consequently, there is growing interest in exploring innovative therapeutic approaches to improve clinical outcomes and enhance the quality of life for breast cancer patients.
  • 367
  • 09 Nov 2023
Topic Review
Targeted Therapies for Triple Negative Breast Cancer
Triple negative breast cancer (TNBC) is a heterogeneous group of breast cancers characterized by their lack of estrogen receptors, progesterone receptors, and the HER2 receptor. They are more aggressive than other breast cancer subtypes, with a higher mean tumor size, higher tumor grade, the worst five-year overall survival, and the highest rates of recurrence and metastasis.
  • 168
  • 09 Nov 2023
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