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Topic Review
Food Wastes as Packaging Materials
Packaging materials have to allow controlled respiration, maintain polymer structure against mechanical damage, prevent microbiological and chemical spoilage of food, and act as a selective gas and water vapor barrier. The most widely used materials in the food packaging industry are glass, plastics, metals, and paper. As mechanical properties of materials are important for food protection, mostly flexible and rigid synthetic packaging materials are preferred.
  • 3.2K
  • 19 Aug 2021
Topic Review
Significance of Glycerol in Biochemistry
Glycerol (C3H8O3), also known as propane-1,2,3-triol, is a significant biomolecule [1]. It is chemically classified as a ‘polyol with a molar mass of 92.09382 g/mol, a density of 1.26 g/cm3, and a boiling point of 554 °F (290 °C). In this section, we shall highlight some key roles this molecule plays in the biochemistry of life.
  • 3.1K
  • 26 Jan 2021
Topic Review
Protein Quality Control (PQC)
Eukaryotic cells have a well-organized, tightly regulated protein quality control (PQC) system. This quality control system includes the molecular chaperones, ubiquitin/proteasome-dependent protein degradation, and autophagy machinery (target and uptake of non-native conformer in the spatial compartments) that consistently monitors and maintains the conformational state of cellular proteins.
  • 3.1K
  • 18 Mar 2021
Topic Review
The Process of Wound Healing
Wound healing is a recovering process of damaged tissues by replacing dysfunctional injured cellular structures. Wounds occur as a result of accidental or surgical trauma and from a variety of medical conditions. This wound often causes pain, inflammation, and loss of function, which affects a patient’s life and financial costs.
  • 3.0K
  • 06 Sep 2022
Topic Review
The Epididymis
The epididymis is a convoluted, crescent-shaped structure that connects the testis to the vas deferens and has four main anatomical regions each with unique characteristics and functions: the initial segment, caput (head), corpus (body) and cauda (tail).
  • 2.8K
  • 05 Nov 2020
Topic Review
Matrix Metalloproteinases and Their Inhibitors
Matrix metalloproteinases (MMPs) are a family of zinc-dependent extracellular matrix (ECM) remodeling endopeptidases that have the capacity to degrade almost every component of the ECM. The degradation of the ECM is of great importance, since it is related to embryonic development and angiogenesis. It is also involved in cell repair and the remodeling of tissues. When the expression of MMPs is altered, it can generate the abnormal degradation of the ECM. This is the initial cause of the development of chronic degenerative diseases and vascular complications generated by diabetes. In addition, this process has an association with neurodegeneration and cancer progression. Within the ECM, the tissue inhibitors of MMPs (TIMPs) inhibit the proteolytic activity of MMPs. TIMPs are important regulators of ECM turnover, tissue remodeling, and cellular behavior. Therefore, TIMPs (similar to MMPs) modulate angiogenesis, cell proliferation, and apoptosis. An interruption in the balance between MMPs and TIMPs has been implicated in the pathophysiology and progression of several diseases.
  • 2.8K
  • 18 Sep 2021
Topic Review
Lipid Peroxidation
Lipid peroxidation refers to the process in which lipids are oxidized to generate lipid peroxides as a primary product. Cellular lipid peroxidation can occur through different reactions, but they can be categorized into enzyme and non-enzyme dependent reactions. The primary substrates in lipid peroxidation reactions are polyunsaturated lipids since carbon-carbon double bonds are susceptible to reactive oxygen species, such as the hydroxyl radical (HO•), which is a key radical that participates in peroxidation reactions.
  • 2.8K
  • 14 Dec 2020
Topic Review
Non-Enzymatic Antioxidants
Oxidative stress has long been considered one of the pathophysiological mechanisms involved in numerous diseases, which has led to the investigation of the antioxidant systems as a promising therapy more than two decades ago. A useful antioxidant must meet specific characteristics; it must be capable of interacting with biologically relevant oxidants and free radicals; its reaction by-products should be harmless; and finally, it must reach a sufficiently high concentration in the tissue and cell compartments to ensure its activity is quantitatively relevant.
  • 2.8K
  • 24 May 2022
Topic Review
Applications of Tannins
The origin of tannins, their historical evolution, their different types, and their applications are described. Old and established applications are described, as well as the future applications which are being developed at present and that promise to have an industrial impact in the future. The chemistry of some of these applications is discussed where it is essential to understand the tannins and their derivates role. The essential points of each application, their drawbacks, and their chance of industrial application are briefly discussed.
  • 2.7K
  • 29 Jul 2021
Topic Review
Lysyl oxidase like 2
LOXL2 is a key enzyme that catalyzes the cross-linking of collagen fibers and forms an integral part in collagen homeostasis. It is thus needed for normal functioning of the myocardium and is pertinent to cardiac remodeling [13]. Dysregulation of its expression is a major driver of muscle stiffness through induced cardiac fibrosis [24,25,43], which reduces cardiac output. In fact, it has been proposed that decreasing excessive collagen cross-linking would reduce myocardial fibrosis and stiffness and thereby improve heart function [44].
  • 2.7K
  • 20 Aug 2020
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