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Topic Review
HMG-CoA-Reductase
3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoAR) is an enzyme involved in the biosynthesis of cholesterol and an important target in the treatment of hypercholesterolemia.
  • 4.7K
  • 29 Oct 2020
Topic Review
Collagen
Collagen is the major fibrillar protein in most living organisms. Among the different types of collagen, type I collagen is the most abundant one in the tissues of marine invertebrates. The present overview has focused on a brief history of collagen, basic structure and synthesis, nomenclature, types, and classifications, sources of collagen with the emphasis on sea cucumber collagen, and related functional properties.
  • 4.7K
  • 13 Oct 2020
Topic Review
Hyaluronic Acid
Hyaluronic acid, as a natural linear polysaccharide, has attracted researchers’ attention from its initial detection and isolation from tissues in 1934 until the present day. Due to biocompatibility and a high biodegradation of hyaluronic acid, it finds wide application in bioengineering and biomedicine: from biorevitalizing skin cosmetics and endoprostheses of joint fluid to polymeric scaffolds and wound dressings. However, the main properties of aqueous polysaccharide solutions with different molecular weights are different. Moreover, the therapeutic effect of hyaluronic acid-based preparations directly depends on the molecular weight of the biopolymer. The present entry collects the information about hyaluronic acid and its original properties. Particular emphasis is placed on the structural, physical and physico-chemical properties of hyaluronic acid in water solutions, as well as their degradability.
  • 4.5K
  • 31 Aug 2020
Topic Review
Enzymatic Reactions in Honey
Honey is known for its content of biomolecules, such as enzymes. The enzymes of honey originate from bees, plant nectars, secretions or excretions of plant-sucking insects, or microorganisms such as yeasts. Honey can be characterized by enzyme-catalyzed and non-enzymatic reactions. Notable examples of enzyme-catalyzed reactions are the production of hydrogen peroxide through glucose oxidase activity and the conversion of hydrogen peroxide to water and oxygen by catalase enzymes. 
  • 4.4K
  • 19 Aug 2022
Topic Review
Genome-wide association studies (GWAS)
Genome-wide association studies (GWAS) are studies assessing and analyzing either differences or variations in DNA sequences across the human genome to detect genetic risk factors of diseases prevalent within a target population under study.
  • 4.3K
  • 24 Aug 2020
Topic Review
Fatty Acid Synthase
Fatty acid synthase is a multi-enzyme protein that involves in fatty acid synthesis. It's main function is to synthesise palmitate, a 16-carbon long chain saturated fatty acid from acetyl-CoA and malonyl-CoA, in the presence of NADPH.
  • 4.0K
  • 01 Sep 2020
Topic Review
Stilbene Biosynthesis
Stilbenes are a small family of polyphenolic secondary metabolites that can be found in several distantly related plant species. These compounds act as phytoalexins, playing a crucial role in plant defense against phytopathogens, as well as being involved in the adaptation of plants to abiotic environmental factors. Among stilbenes, trans-resveratrol is certainly the most popular and extensively studied for its health properties. However, many other stilbenes, both monomeric and oligomeric, are currently under intensive investigation due to their biological role and bioactivity.
  • 3.8K
  • 14 Jan 2021
Topic Review
Mango (Mangifera indica L.) Leaves
Mango (Mangifera indica L.) ascribed to the family Anacardiaceae has been adjudged as the vital traditionally significant and one of the most economically important tropical fruit crop globally.
  • 3.8K
  • 28 May 2021
Topic Review
Aquaporin Inhibitors
Aquaporins (AQPs) are water channel proteins that are essential to life, being expressed in all kingdoms. In humans, there are 13 AQPs, at least one of which is found in every organ system. The structural biology of the AQP family is well-established and many functions for AQPs have been reported in health and disease. AQP expression is linked to numerous pathologies including tumor metastasis, fluid dysregulation, and traumatic injury. The targeted modulation of AQPs therefore presents an opportunity to develop novel treatments for diverse conditions. Various techniques such as video microscopy, light scattering and fluorescence quenching have been used to test putative AQP inhibitors in both AQP-expressing mammalian cells and heterologous expression systems. The inherent variability within these methods has caused discrepancy and many molecules that are inhibitory in one experimental system (such as tetraethylammonium, acetazolamide, and anti-epileptic drugs) have no activity in others. Some heavy metal ions (that would not be suitable for therapeutic use) and the compound, TGN-020, have been shown to inhibit some AQPs. Clinical trials for neuromyelitis optica treatments using anti-AQP4 IgG are in progress. However, these antibodies have no effect on water transport. More research to standardize high-throughput assays is required to identify AQP modulators for which there is an urgent and unmet clinical need.
  • 3.7K
  • 06 Sep 2021
Topic Review
Sesquiterpene Lactones
Sesquiterpene lactones, a vast group of terpenoids isolated from Asteraceae family species, exhibit a wide variety of biological activities and several of them are already available on the medicines market, such as artemisinin. Here are presented and discussed the most recent and impactful results in vivo, preclinical and clinical studies, involving a selection of ten sesquiterpene lactones (alantolactone, arglabin, costunolide, cynaropicrin, helenalin, inuviscolide, lactucin, parthenolide, thapsigargin and tomentosin) and some of their derivatives.
  • 3.5K
  • 28 Oct 2020
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