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Topic Review
Biography
Topic Review
Zebrafish Models of Neuroblastoma
For nearly a decade, researchers in the field of pediatric oncology have been using zebrafish as a model for understanding the contributions of genetic alternations to the pathogenesis of neuroblastoma (NB), and exploring the molecular and cellular mechanisms that underlie neuroblastoma initiation and metastasis.
964
18 Mar 2021
Topic Review
CAR T-Cells
Chimeric Antigen Receptor (CAR) T-cells are T lymphocytes that have been specifically engineered to target malignant cells. CARs are synthetic molecules designed to activate T cells in response to a specific antigen, mimicking T cell activation through the T cell receptor (TCR) and associated costimulatory molecules.
524
18 Mar 2021
Topic Review
MicroRNA-Assisted Hormone Cell Signaling
miRNAs role in hormone signaling pathways in CRC drug resistance and their potential as future targets for overcoming resistance to treatment.
575
18 Mar 2021
Topic Review
Spondylocostal Dysostosis (SCDO)
Spondylocostal dysostosis (SCDO) is a rare heritable congenital condition, characterized by multiple severe malformations of the vertebrae and ribs.
1.4K
18 Mar 2021
Topic Review
Malarial Protozoan Parasites Infection
Malaria is an infectious disease caused by protozoan parasites of the Plasmodium genus through the bite of female Anopheles mosquitoes, affecting 228 million people and causing 415 thousand deaths in 2018. Artemisinin-based combination therapies (ACTs) are the most recommended treatment for malaria; however, the emergence of multidrug resistance has unfortunately limited their effects and challenged the field.
627
17 Mar 2021
Topic Review
Collagen Type XI Alpha 1
Collagen type XI alpha 1 (COL11A1) is one of the alpha chains of type XI collagen, which is important for bone development. Interestingly, COL11A1 levels are frequently upregulated in various cancers and high levels of COL11A1 are correlated with poor clinical outcome in many solid cancers. Increasing evidence shows that COL11A1 promotes tumor cell aggressiveness through multiple mechanisms.
768
15 Mar 2021
Topic Review
Perineuronal Nets
During restricted time windows of postnatal life, called critical periods, neural circuits are highly plastic and are shaped by environmental stimuli. In several mammalian brain areas, from the cerebral cortex to the hippocampus and amygdala, the closure of the critical period is dependent on the formation of perineuronal nets (PNNs). PNNs are condensed aggregates of an extracellular matrix (ECM) enwrapping the cell body, dendrites, and axon initial segments of several neurons in the adult central nervous system (CNS). They represent one form of an ECM in the CNS, together with the ECM that is loosely distributed in the parenchyma, the ECM that constitutes the basal lamina (which separates the CNS tissue from meningeal and vascular tissues), and the ECM that is located at the nodes of Ranvier.
865
11 Mar 2021
Topic Review
Intraoperative Flow Cytometry
Flow Cytometry is an analytical technique with the ability to quantify cell phenotype and to categorize cell populations on the basis of their characteristics. Intraoperative Flow Cytometry (iFC) is the use of flow cytometry during tumor excision for rapid diagnosis of cancer cells and determination of tumor margins.
383
11 Mar 2021
Topic Review
Hematopoietic Cell Transplant
Following primary infection, herpesviruses establish latency in infected individuals in the host cells and may reactivate upon external stimuli and during periods of immunosuppression.
356
10 Mar 2021
Topic Review
Tunneling Nanotubes
Tunneling nanotubes (TNTs) are recognized long membrane nanotubes connecting distance cells. In the last decade, growing evidence has shown that these subcellular structures mediate the specific transfer of cellular materials, pathogens, and electrical signals between cells. As intercellular bridges, they play a unique role in embryonic development, collective cell migration, injured cell recovery, cancer treatment resistance, and pathogen propagation. Although TNTs have been considered as potential drug targets for treatment, there is still a long way to go to translate the research findings into clinical practice.
640
10 Mar 2021
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