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Topic Review
Reentry Arrhythmia in Cardiac Tissue Models
Cardiac arrhythmias are a major cause of cardiovascular mortality worldwide. Many arrhythmias are caused by reentry, a phenomenon where excitation waves circulate in the heart. Optical mapping techniques have revealed the role of reentry in arrhythmia initiation and fibrillation transition, but the underlying biophysical mechanisms are still difficult to investigate in intact hearts.
  • 316
  • 17 Oct 2023
Topic Review
Membrane Protein Preparation for Single-Particle Cryo-Electron Microscopy Analysis
Single-particle cryo-electron microscopy (cryo-EM SPA) has emerged as an exceptionally well-suited technique for determining the structure of membrane proteins (MPs). Indeed, huge increase in the number of MPs solved via cryo-EM SPA at a resolution better than 3.0 Å in the Protein Data Bank (PDB) has been observed. However, sample preparation remains a significant challenge in the field. 
  • 237
  • 13 Oct 2023
Topic Review
Necroptosis in Solid Organ Transplantation
Necroptosis is a type of programmed cell death involved in many diseases and has been studied in the setting of all major solid organ transplants, including the kidney, heart, liver, and lung. It is determined by the underlying donor organ conditions (e.g., age, alcohol consumption, fatty liver, hemorrhage shock, donation after circulatory death, etc.), preservation conditions and reperfusion, and allograft rejection. The specific molecular mechanisms of necroptosis have been uncovered in the organ transplantation setting, and potential targeting drugs have been identified.
  • 207
  • 11 Oct 2023
Topic Review
QED Coherence and Hormesis: Foundations of Quantum Biology
“Quantum biology” (QB) is a promising theoretical approach addressing questions about how living systems are able to unfold dynamics that cannot be solved on a chemical basis or seem to violate some fundamental laws (e.g., thermodynamic yield, morphogenesis, adaptation, autopoiesis, memory, teleology, biosemiotics). Current “quantum” approaches in biology are still very basic and “corpuscular”, as these rely on a semi-classical and approximated view. The important considerations of theory and experiments of the recent past in the field of condensed matter, water, physics of living systems, and biochemistry to join them by creating a consistent picture applicable for life sciences is summarized. Within quantum field theory (QFT), the field (also in the matter field) has the primacy whereby the particle, or “quantum”, is a derivative of it.
  • 246
  • 29 Sep 2023
Topic Review
Optical Biosensors for COVID-19 and Other Viruses Diagnosis
The sudden outbreak of the COVID-19 pandemic led to a huge concern globally because of the astounding increase in mortality rates worldwide. The medical imaging computed tomography technique, whole-genome sequencing, and electron microscopy are the methods generally used for the screening and identification of the SARS-CoV-2 virus.
  • 156
  • 28 Sep 2023
Topic Review
Nuclear Magnetic Resonance Applications on Bovine Milk
Nuclear magnetic resonance (NMR) spectroscopy is emerging as a promising technique for the analysis of bovine milk, primarily due to its non-destructive nature, minimal sample preparation requirements, and comprehensive approach to untargeted milk analysis. These inherent strengths of NMR make it a formidable complementary tool to mass spectrometry-based techniques in milk metabolomic studies.
  • 189
  • 15 Sep 2023
Topic Review
Artificial Intelligence-based Algorithms for Cryo-Electron Microscopy
Single particle cryo-electron microscopy (cryo-EM) has emerged as the prevailing method for near-atomic structure determination, shedding light on the important molecular mechanisms of biological macromolecules. However, the inherent dynamics and structural variability of biological complexes coupled with the large number of experimental images generated by a cryo-EM experiment make data processing nontrivial. In particular, ab initio reconstruction and atomic model building remain major bottlenecks that demand substantial computational resources and manual intervention. Approaches utilizing recent innovations in artificial intelligence (AI) technology, particularly deep learning, have the potential to overcome the limitations that cannot be adequately addressed by traditional image processing approaches.
  • 226
  • 08 Sep 2023
Topic Review
AFM Investigation of Protein Crystals Morphology
Atomic force microscopy (AFM) enables the visualization of soft samples over a wide size range, from hundreds of micrometers up to the molecular level. The nonperturbative nature, the ability to scan in a liquid environment, and the lack of need for freezing, fixing, or staining make AFM a well-suited tool for studying fragile samples such as macromolecular crystals. The achievements of AFM underlined start from the study of crystal growth processes studying the surface morphology of protein crystals, passes through the in-depth analysis of the S-layer systems, and arrive at the introduction of the high-speed atomic force microscopy (HS-AFM) that allows the observation of molecular dynamics adsorption.
  • 171
  • 06 Sep 2023
Topic Review
Human SRC Homology 3 Domains
SRC homology 3 (SH3) domains are fundamental modules that enable the assembly of protein complexes through physical interactions with a pool of proline-rich/noncanonical motifs from partner proteins. They are widely studied modular building blocks across all five kingdoms of life and viruses, mediating various biological processes. The SH3 domains are also implicated in the development of human diseases, such as cancer, leukemia, osteoporosis, Alzheimer’s disease, and various infections.
  • 317
  • 16 Aug 2023
Topic Review
Textile Electrodes for Wearable Biopotential Signal Monitoring
The technology of wearable medical equipment has advanced to the point where it is now possible to monitor the electrocardiogram and electromyogram comfortably at home. The transition from wet Ag/AgCl electrodes to various types of gel-free dry electrodes has made it possible to continuously and accurately monitor the biopotential signals. Fabrics or textiles, which were once meant to protect the human body, have undergone significant development and are now employed as intelligent textile materials for healthcare monitoring. The conductive textile electrodes provide the benefit of being breathable and comfortable.
  • 202
  • 11 Aug 2023
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