Subject:
All Disciplines Arts & Humanities Biology & Life Sciences Business & Economics Chemistry & Materials Science Computer Science & Mathematics Engineering Environmental & Earth Sciences Medicine & Pharmacology Physical Sciences Public Health & Healthcare Social Sciences
Sort:
Hottest Latest Alphabetical (A-Z) Alphabetical (Z-A)
Type:
All Topic Review Biography
Topic Review
Platinum Based Cytostatic Drugs
Platinum based cytostatic drugs (Pt CDs) are among the most used drugs in cancer treatments which are administered via intravenous infusion and released partially intact or as transformation products. 
  • 653
  • 19 Apr 2022
Topic Review
Fluorescent Chemosensors Based on Polyamine Ligands
Polyamine ligands are water-soluble receptors that are able to coordinate, depending on their protonation degree, either metal ions, anionic, or neutral species. Furthermore, the presence of fluorescent signaling units allows an immediate visual response/signal. For these reasons, they can find applications in a wide variety of fields, mainly those where aqueous media is necessary, such as biological studies, wastewater analysis, soil contamination, etc.
  • 641
  • 29 Dec 2021
Topic Review
C,C- and C,N-Chelated Organocopper Compounds
Copper-catalyzed and organocopper-involved reactions are of great significance in organic synthesis. To have a deep understanding of the reaction mechanisms, the structural characterizations of organocopper intermediates become indispensable. Meanwhile, the structure-function relationship of organocopper compounds could advance the rational design and development of new Cu-based reactions and organocopper reagents. Compared to the mono-carbonic ligand, the C,N- and C,C-bidentate ligands better stabilize unstable organocopper compounds. Bidentate ligands can chelate to the same copper atom via η2-mode, forming a mono-cupra-cyclic compounds with at least one acute C-Cu-C angle. When the bidentate ligands bind to two copper atoms via η1-mode at each coordinating site, the bimetallic macrocyclic compounds will form nearly linear C-Cu-C angles. The anionic coordinating sites of the bidentate ligand can also bridge two metals via μ2-mode, forming organocopper aggregates with Cu-Cu interactions and organocuprates with contact ion pair structures. The reaction chemistry of some selected organocopper compounds is highlighted, showing their unique structure–reactivity relationships.
  • 621
  • 08 Oct 2021
Topic Review
Zn(II) AIEgens: “Clip Approach”
 Aggregation-induced emission (AIE) compounds display a photophysical phenomenon inwhich the aggregate state exhibits stronger emission than the isolated units. The common term of“AIEgens” was coined to describe compounds undergoing the AIE effect. Due to the recent interestin AIEgens, the search for novel hybrid organic–inorganic compounds with unique luminescenceproperties in the aggregate phase is a relevant goal. In this perspective, the abundant, inexpensive,and nontoxic d10 zinc cation offers unique opportunities for building AIE active fluorophores, sensingprobes, and bioimaging tools. Considering the novelty of the topic, relevant examples collected inthe last 5 years (2016–2021) through scientific production can be considered fully representative ofthe state-of-the-art. Starting from the simple phenomenological approach and considering differenttypological and chemical units and structures, we focused on zinc-based AIEgens offering syntheticnovelty, research completeness, and relevant applications. A special section was devoted to Zn(II)-based AIEgens for living cell imaging as the novel technological frontier in biology and medicine.
  • 620
  • 22 Jul 2021
Topic Review
Journal Inorganics
Inorganics (ISSN 2304-6740; CODEN: INORCW) is an international, scientific, peer-reviewed, open access journal of inorganic chemistry published monthly online by MDPI.  It has been indexed in Chemical Abstracts, Scopus, and Web of Science.
  • 615
  • 26 Sep 2021
Topic Review
Metal-Based Chemotherapeutic Treatments
Herein we provides an overview of the various research approaches we have explored in recent years to improve metal-based agents for cancer or infection treatments. Although cisplatin, carboplatin, and oxaliplatin remain the cornerstones in tumor chemotherapy, the discovery and approval of novel inorganic anticancer drugs is a very slow process. Analogously, although a few promising inorganic drugs have found clinical application against parasitic or bacterial infections, their use remains relatively limited. Moreover, the discovery process is often affected by small therapeutic enhancements that are not attractive for the pharmaceutical industry. However, the availability of increasing mechanistic information for the modes of action of established inorganic drugs is fueling the exploration of various approaches for developing effective inorganic chemotherapy agents. Through a series of examples, some from our own research experience, we focus our attention on a number of promising strategies, including (1) drug repurposing, (2) the simple modification of the chemical structures of approved metal-based drugs, (3) testing novel drug combinations, and (4) newly synthesized complexes coupling different anticancer drugs. Accordingly, we aim to suggest and summarize a series of reliable approaches that are exploitable for the development of improved and innovative treatments.
  • 581
  • 25 May 2021
Topic Review
Catalysts for Glycerol Reforming
The valuable products produced from glycerol transformation have become a research route that attracted considerable benefits owing to their huge volumes as well as a myriad of chemical and biological techniques for transforming glycerol into high-value compounds, such as fuel additives, biofuels, precursors, and other useful chemicals, etc. Steam, aqueous, and autothermal reforming processes have been primarily investigated in glycerol reforming. An update on glycerol reforming is given, with an exclusive focus on the various catalyst's performance in designing reaction operation conditions.
  • 569
  • 25 Jul 2022
Topic Review
Structure and Functions of Aβ and Tau Proteins
The amyloid hypothesis, i.e., the abnormal accumulation of toxic Aβ assemblies in the brain, has been considered the mainstream concept sustaining research in Alzheimer’s Disease (AD). However, the course of cognitive decline and AD development better correlates with tau accumulation rather than amyloid peptide deposition. Moreover, all clinical trials of amyloid-targeting drug candidates have been unsuccessful, implicitly suggesting that the amyloid hypothesis needs significant amendments. Accumulating evidence supports the existence of a series of potentially dangerous relationships between Aβ oligomeric species and tau protein in AD.
  • 525
  • 29 Aug 2022
Topic Review
Uranium Sulfate
Uranium sulfate (U(SO4)2) is a water-soluble salt of uranium. It is a very toxic compound. Uranium sulfate minerals commonly are widespread around uranium bearing mine sites, where they usually form during the evaporation of acid sulfate-rich mine tailings which have been leached by oxygen-bearing waters. Uranium sulfate is a transitional compound in the production of Uranium hexafluoride. It was also used to fuel aqueous Homogeneous Reactors.
  • 509
  • 28 Oct 2022
Topic Review
Organometallic Chemistry of Guanidines
Guanidines, nitrogen-rich compounds, appear as one such potential alternatives as ligands or proligands. In addition to occurring in a plethora of natural compounds, and thus in compounds of pharmacological use, guanidines allow a wide variety of coordination modes to different metal centers along the periodic table, with their monoanionic chelate derivatives being the most common.
  • 504
  • 18 Oct 2022
  • Page
  • of
  • 9
Featured Entry Collections
>>

Featured Books

>>
Encyclopedia of Social Sciences
Encyclopedia of COVID-19
Encyclopedia of Fungi
Encyclopedia of Digital Society, Industry 5.0 and Smart City
Feedback