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Topic Review
Chitosan and Fibroin
For the creation of tissue-engineered structures based on natural biopolymers with the necessary chemical, physical, adhesive, morphological, and regenerative properties, biocompatible materials based on polysaccharides and proteins are used.  This entry is devoted to a problem of the technology of polymeric materials for biomedical purposes: the creation of biopolymer tissue engineering matrix and the development of a methodology for studying morphology and functional properties of their surface to establish the prospects for using the material for contact with living objects.
  • 788
  • 12 Apr 2021
Topic Review
Chitosan and its Derivatives
Chitosan (CS) is a hemi-synthetic cationic linear polysaccharide produced by the deacetylation of chitin. CS is non-toxic, highly biocompatible, and biodegradable, and it has a low immunogenicity. Additionally, CS has inherent antibacterial properties and a mucoadhesive character and can disrupt epithelial tight junctions, thus acting as a permeability enhancer. As such, CS and its derivatives are well-suited for the challenging field of ocular drug delivery. In the present review article, we will discuss the properties of CS that contribute to its successful application in ocular delivery before reviewing the latest advances in the use of CS for the development of novel ophthalmic delivery systems. Colloidal nanocarriers (nanoparticles, micelles, liposomes) will be presented, followed by CS gels and lenses and ocular inserts. Finally, instances of CS coatings, aiming at conferring mucoadhesiveness to other matrixes, will be presented.
  • 1.0K
  • 31 Jul 2020
Topic Review
Chitosan and Its Derivatives in Promoting Drug Permeation
Chitosan is the product of N-deacetylation of chitin. Due to the simultaneous presence of amino, acetamido, and hydroxyl groups in the molecule, chitosan is quite active in nature and can be modified, activated, and coupled, showing rich functionality and modifiability in biological applications. As the only polycationic polymer of natural origin, chitosan is capable of interacting with negatively charged cell membranes to assist the loading of drugs across the cell membrane.
  • 550
  • 21 Apr 2022
Topic Review
Chitosan as a Biomaterial
Chitosan remarkable properties have aroused the interest of applying this material in several biomedical applications, such as tissue engineering, wound dressing, drug delivery, and cancer treatment, what has aroused the interest of this review to gather the state-of-the-art concerning this polysaccharide when used as a biomaterial, providing information about its characteristics, chemical modifications, and applications.
  • 655
  • 25 Nov 2020
Topic Review
Chitosan Films Barrier improvement
Chitosan is produced commercialy by deacetylation of chitin (a molecule derivative from glucose, and the second most plentiful natural polysaccharide found on our planet after cellulose) and chitosan films have been studied for food preservation, since they are biocompatible, biodegradable, and bioactive. However, their performance, in terms of water and gases barrier properties, needs to be improved.
  • 1.2K
  • 22 Apr 2021
Topic Review
Chitosan in Fish Biotechnology
Chitosan is increasingly used for safe drug and nucleic acid delivery due to well-known properties such as bioadhesion, low toxicity, biodegradability and biocompatibility. Furthermore, chitosan derivatization can be easily performed to improve solubility and stability of chitosan-nucleic acid polyplexes, and enhance efficient target cell drug delivery, cell uptake, intracellular endosomal escape, unpacking and nuclear import of expression plasmids. This review focus attention on recent advances in chitosan-mediated gene delivery for fish biotechnology applications such as fish vaccination against bacterial and viral infection, control of gonadal development, and gene overexpression and silencing for overcoming metabolic limitations such as dependence on protein-rich diets and low glucose tolerance of farmed fish.
  • 2.2K
  • 27 Oct 2020
Topic Review
Chitosan in Metal Nanoparticles Synthesis
Chitosan (CS) has been widely used as a surface coating for metal nanoparticles. CS can work as a reducing agent, a shape director, or a size-controllable agent in the synthesis of metal nanoparticles. The previous studies have shown that functionalizing the surface of metal nanoparticles by CS can offer many advantages, including improving physicochemical stability, a drug carrier, controlling drug release, promoting muco-adhesiveness and tissue penetration, encouraging cell interactions, and enhancing antimicrobial effects.
  • 717
  • 19 Feb 2021
Topic Review
Chitosan in Sustainable Development
The chitosan shows interesting and unique properties, thus it can be used for different purposes which contributes to the design and development of sustainable novel materials. This helps in promoting sustainability through the use of chitosan and diverse materials based on it. 
  • 479
  • 19 Apr 2022
Topic Review
Chitosan Nanocomposite Coatings
Functional nanocomposites with biopolymers and zinc oxide (ZnO) nanoparticles is an emerging application of photocatalysis in antifouling coatings. The reduced chemical stability of ZnO photocatalyst in the acidic media in which chitosan is soluble affects the performance of chitosan nanocomposites in antifouling applications. In this study, a thin shell of amorphous tin oxide (SnOx) was grown on the surface of ZnO to form ZnO–SnOx core–shell nanoparticles that improved the chemical stability of the photocatalyst, as examined at pH 3 and 6. The photocatalytic activity of ZnO–SnOx in the degradation of methylene blue (MB) dye under visible light showed a higher efficiency than that of ZnO nanoparticles due to improved electron-hole separation. Meanwhile, the incorporation of photocatalysts into the chitosan matrix enhanced the thermal stability of the coatings. Chitosan-based antifouling coatings with varying percentages of ZnO or ZnO–SnOx nanoparticles, with or without the glutaraldehyde (GA) crosslinking of chitosan, were developed and studied for the prevention of biofouling. 
  • 519
  • 19 May 2021
Topic Review
Chitosan Nanostructures
Chitosan (CS) is a natural polymer with a positive charge, a deacetylated derivative of chitin. Chitosan nanostructures (nano-CS) have received increasing interest due to their potential applications and remarkable properties. 
  • 576
  • 04 Nov 2021
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