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Topic Review
Carbonation of Concrete
As one of the major causes of concrete deterioration, the carbonation of concrete has been widely investigated over recent decades. In recent years, the effect of mechanical load on carbonation has started to attract more attention. The load-induced variations in crack pattern and pore structure have a significant influence on CO2 transport which determines the carbonation rate. 
  • 1.3K
  • 07 Dec 2021
Topic Review
Carbonic Anhydrase in Cerebral Ischemia
Ischemic stroke is a leading cause of death and disability worldwide. The only pharmacological treatment available to date for cerebral ischemia is tissue plasminogen activator (t-PA) and the search for successful therapeutic strategies still remains a major challenge. The loss of cerebral blood flow leads to reduced oxygen supply and a subsequent switch to the glycolytic pathway, which leads to tissue acidification. Carbonic anhydrase (CA, EC 4.2.1.1) is the enzyme responsible for converting carbon dioxide into a protons and bicarbonate, thus contributing to pH regulation and metabolism, with many CA isoforms present in the brain. Recently, numerous studies have shed light on several classes of carbonic anhydrase inhibitor (CAI) as possible new pharmacological agents for the management of brain ischemia. 
  • 560
  • 21 May 2021
Topic Review
Carbonization Reactions in Biomass Pyrolysis Processes
Biochar is a carbon-rich solid produced during the thermochemical processes of various biomass feedstocks. Biomass pyrolysis is one of the most common processes to produce biochar.
  • 253
  • 29 Aug 2023
Topic Review
Cardiac Glycosides
Cardiac glycosides (CG’s) are naturally occurring biologically active small molecules, used to diagnose a diversity of heart diseases such as congestive heart failure and cardiac arrhythmia. The story of CG’s started over 100 years ago when Sir William Withering reported the use of foxglove plant for treating “dropsy” associated with congestive heart failure and the foxglove plant (Digitalis purpurea) was still in the use for the extraction of Digoxin, a cardiac glycoside used to treat congestive heart failures (Johnson., 2012). The core structure of CGs comprises a steroid nucleus attached to a five-membered lactone ring (cardenolide) or six-membered lactone rings (bufadienolides) along with sugar moieties. Major plant-derived CGs were obtained from plant families of Apocynaceae, Scrophulariaceae, and Asparagaceae (Thevitia neriifolia, Neerium oleander, Digitalis purpurea, Digitalis lanata, Urginea maritime, and Strophanthus kombe). Structurally, all these contain a core steroid nucleus connected with sugar moiety at C3 position and lactone moiety at C17 position (Figure 1.3). The pharmacological significance of all the CG’s lies in the core steroid confirmation that contains A/B and C/D cis- portions and the properties such as pharmacokinetics and pharmacodynamics lie between the confined sugars molecules (Pongrakhananon., 2013). Apart from the plant sources, CG’s were also isolated from several animal species such as bufadienolide was isolated from frogs, and also mammalian tissues contain a cardiac glycoside which is similar to endogenous digitalis (Melero et al., 2000). Quite a few studies have conveyed that the human body does contain a lot more CG’s in different parts. For example, the plasma membrane contains Ouabain and Proscillaridin A and human urine contains digoxin and marinobufagenin whereas human lenses consist of 19-norbufalin (Schoner and Scheiner-Bobis., 2007). In the year 1785, William Withering was the first person to use a digitalis compound from Digitalis purpurea to treat congestive heart failures. Currently, Digoxin is used for treating congestive heart failures. The mechanism of action of Digoxin is that it can inhibit the sodium-potassium pump (Na+/K+-ATPase). Living organisms maintain more percentage of K+ within the cell and less percentage of Na+. However, the scenario at the outside of the cell is quite opposite to the intracellular conditions where a high percentage of Na+ and less percentage of K+ will be maintained. Hence, there is a concentration incline that exists between the outside and inside cellular environments, which will be maintained by sodium-potassium pump. The Na+/K+-ATPase is recognized as a transmembrane protein whose functions are to maintain ionic balance in the heart tissue. Na+/K+-ATPase utilizes ATP as the whole energy source, to exchange two K+ ions inside the cell and pushes three Na+ ions outside to maintain intra cellular homeostasis. Also, Na+/K+-ATPase transports glucose and amino acids by keeping less concentration of Na+ within the cell and helps in the maintenance of electrochemical incline. The increment of the Na+ level inside the cell retort to CGs fortifies the ion exchange mechanism. This leads to the expansion of intracellular Ca2+ percentage which therefore promotes organelle instances such as myocardial contractibility, and generates optimistic inotropic effects in the heart cell with CGs (Kaplan., 2002).  
  • 1.7K
  • 12 Aug 2020
Topic Review
Cardiomyocytes Contractile Activity on Poly(vinyl-alcohol)/Bioglass Electrospun Scaffolds
Tissue scaffolds are generally used as three-dimensional structural supports destined to mimic the morphological structure and function in regeneration processes. Still, beyond this, they are expected to perform the physiological functions for which each tissue or organ is intended. In the case of cardiac tissue, it brings oxygen through the blood to each part of the body through the contraction of the cardiac muscle cells (cardiomyocytes). This contraction is neurologically stimulated through a voltage and calcium-dependent process denominated excitation-contraction coupling, which is mediated by several factors. In this sense, the composition of the scaffold becomes relevant.
  • 142
  • 05 Mar 2024
Topic Review
Cardioprotective Activity of Polyphenols
Polyphenols have recently gained popularity among the general public as products and diets classified as healthy and containing naturally occurring phenols. Many polyphenolic extracts are available on the market as dietary supplements, functional foods, or cosmetics, taking advantage of clients' desire to live a healthier and longer life.   
  • 785
  • 29 Dec 2020
Topic Review
Carica papaya Leaf Extract
Carica papaya (papaya) leaf extract has been used for a long time in a traditional medicine to treat fever in some infectious diseases such as dengue, malaria, and chikungunya. The development of science and technology has subsequently made it possible to provide evidence that this plant is not only beneficial as an informal medication, but also that it has scientifically proven pharmacological and toxicological activities, which have led to its formal usage in professional health care systems.
  • 1.5K
  • 08 Dec 2021
Topic Review
Carotenoid-Loaded Nanocarriers for Alzheimer’s Disease Therapy
Natural bioactive compounds have emerged as a strategy for Alzheimer’s disease treatment. Carotenoids, including astaxanthin, lycopene, lutein, fucoxanthin, crocin and others are natural pigments and antioxidants, and can be used to treat a variety of diseases, including Alzheimer’s disease. However, carotenoids, as oil-soluble substances with additional unsaturated groups, suffer from low solubility, poor stability and poor bioavailability. Therefore, the preparation of various nano-drug delivery systems from carotenoids is a current measure to achieve efficient application of carotenoids. Different carotenoid delivery systems can improve the solubility, stability, permeability and bioavailability of carotenoids to a certain extent to achieve Alzheimer’s disease efficacy.
  • 377
  • 03 May 2023
Topic Review
Carrageenan-Based Hard Capsules: Review
Carrageenan is used as a gelling agent in products, such as frozen foods, jellies and yogurt. Commercially, carrageenan has been produced in six different types based on their structures. Among the six polymers, κ-carrageenan is the most produced due to its high gelling ability caused by the C4 conformation on the 3,6-anhydro-D-galactopyranosyl that forms a helix-like structure. The formation of the helix structure is supported by the enormous number of –OH groups that form many hydrogen bonds.
  • 630
  • 28 Sep 2021
Topic Review
Cartilage Lubrication in Osteoarthritis
The remarkable lubrication properties of normal articular cartilage play an essential role in daily life, providing almost frictionless movements of joints. Alterations of cartilage surface or degradation of biomacromolecules within synovial fluid increase the wear and tear of the cartilage and hence determining the onset of the most common joint disease, osteoarthritis (OA).
  • 637
  • 03 Nov 2021
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