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Topic Review
Technical Lignins
Lignin is a complex, amorphous, natural polymer, and one of the most abundant in nature, only behind cellulose. Technical lignins are co-products of the manufacture of cellulose pulp for paper. Some examples of technical lignins that will be addressed in this study are lignosulphonates alongside kraft, soda and organosolv lignins.
  • 1.1K
  • 19 Dec 2021
Topic Review
Technical Features of Polysaccharide-Based Hydrogels in Drug Delivery
Hydrogels are a form of highly hydrophilic biomaterials with three-dimensional architecture that can retain a significant amount of water and swell without disintegrating. Hydrogels can be either synthetic, natural, or hybrid forms. Natural polymer hydrogels are those derived from naturally sourced polymers, including polysaccharides, polynucleotides, and proteins. Neutral, cationic, and anionic categories describe the chemical properties of natural sources of polymers. These polymers are easily accessible, ubiquitous, affordable, non-toxic, renewable, and have other appealing biological features.
  • 553
  • 22 Dec 2022
Topic Review
TBC-assisted Cooling Air System Simulation
Thermal barrier coating (TBC) and cooling air systems are among the technologies that have been introduced and applied in pursuing the extensive development of advanced gas turbine. TBC is used to protect the gas turbine components from the higher operating temperature of advanced gas turbine, whereas cooling air systems are applied to assist TBC in lowering the temperature exposure of protected surfaces. Generally, a gas turbine operates in three main operational modes, which are base load, peak load, and part peak load. TBC performance under these three operational modes has become essential to be studied, as it will provide the gas turbine owners not only with the behaviors and damage mechanism of TBC but also a TBC life prediction in a particular operating condition.
  • 1.6K
  • 23 Jun 2021
Topic Review
Taxol Biosynthetic Pathway
Taxol is one of the most effective anticancer drugs in the world that is widely used in the treatment of several cancers. The elucidation of the taxol biosynthetic pathway is the key to solve the problem of taxol supply. So far, the taxol biosynthetic pathway has been reported to require an estimated 20 steps of enzymatic reactions, and most of enzymes involved have been well characterized. In details, the source and formation of the taxane core and the process of the downstream synthetic pathway have been basically depicted, while the modification of the core taxane skeleton has not been fully reported, mainly concerning the developments from diol intermediates to 2-debenzoyltaxane. 
  • 1.7K
  • 01 Jun 2021
Topic Review Peer Reviewed
Tautomerism of β-Diketones and β-Thioxoketones
The present overview concentrates on recent developments of tautomerism of β-diketones and β-thioxoketones, both in solution and in the solid state. In particular, the latter has been a matter of debate and unresolved problems. Measurements of 13C, 17O, and 2H chemical shifts have been used. Deuterium isotope effects on chemical shifts are proposed as a tool in the study of this problem. Photoconversion of β-diketones and β-thioxoketones are discussed in detail, and the incorporation of β-diketones into molecules with fluorescent properties is assessed. Finally, docking studies of β-diketones are scrutinized with an emphasis on correct tautomeric structures and knowledge about barriers to interconversion of tautomers.
  • 1.5K
  • 10 Mar 2023
Topic Review
Tautomerism Detected by NMR
Tautomerism is typically the relocation of a light atom, often hydrogen, at the same time as a rearrangement of the electronic structure.  Typical examples are acetylacetone and acetone. This entry gives a short introduction to how to detect and describe a tautomeric equilibrium using Nuclear Magnetic Resonance (NMR). Typical parameters used are chemical shifts (1H,13C,15N,19F and 17O) one-bond coupling constants and isotope effects on chemical shifts.
  • 9.7K
  • 29 Oct 2020
Topic Review
Targeting Nrf2 and NF-κB Signaling Pathways in Cancer
Plant secondary metabolites, known as phytochemicals, have gained much attention in light of the “circular economy”, to reutilize waste products deriving from agriculture and food industry. Phytochemicals are known for their onco-preventive and chemoprotective effects, among several other beneficial properties. Apple phytochemicals have been extensively studied for their effectiveness in a wide range of diseases, cancer included.
  • 336
  • 15 Feb 2023
Topic Review
Targeted Microbubbles for Immunotherapy Applications
Microbubbles are 1–10 μm diameter gas-filled acoustically-active particles, typically stabilized by a phospholipid monolayer shell. In cancer immunotherapy, the microbubble shell can be engineered through the bioconjugation of molecular ligands to facilitate the delivery and uptake of drugs, genes, or cells. This approach allows for precise control of immune stimulation and improves the delivery and pharmacokinetics of immunomodulatory agents at the target site. It has emerged as an attractive strategy for treating various cancer immunotherapy modalities, including monoclonal antibodies, immune checkpoint inhibitors, adoptive cell transfer, cytokine therapy, and vaccines.
  • 337
  • 20 Jun 2023
Topic Review
Targeted Metabolomics Induced by Microplastics
It has been reported that microplastics (MPs)  are present in several organs in different species, including the liver, intestines, kidney, and other organs, where they have the potential to cause detrimental effects such as disrupting endocrine regulation, neurotoxicity, and reproductive toxicity. Therefore, metabolomics studies have attracted considerable attention from researchers who are eager to reveal the mechanism behind the biomarkers that have been discovered by serum chemistry tests, histological tests, or polymerase chain reaction (PCR) analyses. Metabolomics studies can be achieved in two ways, namely targeted and untargeted. Targeted metabolomics detects defined groups of metabolites, providing quantitative results with a high degree of sensitivity and data quality. The advantage of targeted metabolomics is that a complicated data process is not required, but that relatively limited information can be obtained in a single analysis. 
  • 323
  • 05 May 2023
Topic Review
Targeted Delivery of Exosomes to the Brain
Delivering therapeutics to the central nervous system (CNS) is difficult because of the blood–brain barrier (BBB). Therapeutic delivery across the tight junctions of the BBB can be achieved through various endogenous transportation mechanisms. Receptor-mediated transcytosis (RMT) is one of the most widely investigated and used methods. Drugs can hijack RMT by expressing specific ligands that bind to receptors mediating transcytosis, such as the transferrin receptor (TfR), low-density lipoprotein receptor (LDLR), and insulin receptor (INSR). Cell-penetrating peptides and viral components originating from neurotropic viruses can also be utilized for the efficient BBB crossing of therapeutics. Exosomes, or small extracellular vesicles, have gained attention as natural nanoparticles for treating CNS diseases, owing to their potential for natural BBB crossing and broad surface engineering capability. RMT-mediated transport of exosomes expressing ligands such as LDLR-targeting apolipoprotein B has shown promising results.
  • 801
  • 13 May 2022
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