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Topic Review
Natural and Synthetic Halogenated Amino Acids
The 3D structure and surface characteristics of proteins and peptides are crucial for interactions with receptors or ligands and can be modified to some extent to modulate their biological roles and pharmacological activities. The introduction of halogen atoms on the side-chains of amino acids is a powerful tool for effecting this type of tuning, influencing both the physico-chemical and structural properties of the modified polypeptides, helping to first dissect and then rationally modify features that affect their mode of action.
  • 838
  • 16 Dec 2021
Topic Review
Natural and Synthetic Biopolymer Scaffolds
In biomedical applications, scaffolds can be used ranging from regenerative engineering to controlled drug delivery and immunomodulation, and for this purpose, biomaterials have become an indispensable instrument as scaffold material. The materials used for scaffold manufacturing must satisfy some criteria such as intrinsic biofunctionality and appropriate chemistry to stimulate molecular biorecognition by cells to induce proliferation, cell adhesion, and activation. Many biodegradable polymers of natural and synthetic origin have been established for use as biomaterials and careful consideration of the cellular environment and interactions needed is required to select a polymer for a given application.
  • 3.4K
  • 13 Apr 2021
Topic Review
Natural and Synthetic Antifouling Flavonoids
Marine biofouling is a major concern for the maritime industry, environment, and human health. Considering that biocides currently used in marine coatings to prevent this phenomenon are toxic to the marine environment, the search for antifoulants with environmentally safe properties is needed. Some natural and synthetic flavonoids have been evaluated over the last few years for their potential to prevent the settlement and/or the growth of marine organisms on submerged structures, thereby preventing marine biofouling.
  • 238
  • 01 Mar 2024
Topic Review
Natural and Semi-Synthetic Compounds for Wound Healing
Skin wounds are injuries that compromise or damage the structural integrity and optimal functioning of the skin and can be grouped into acute and chronic depending on the skin repair and recovery time frame. Specific interest is given to Aloevera, curcumin, cinnamaldehyde, polyhexanide, retinoids, ascorbate, tocochromanols, and chitosan. These compounds (when alone or in formulation with other biologically active molecules) could be a dependable alternative in the management or prevention of chronic wounds.
  • 771
  • 27 Jun 2022
Topic Review
Natural and Modified Cyclodextrins as Packaging Additives
Cyclodextrins (CDs) have been used by the pharmaceutical and food industries since the 1970s. Their cavities allow the accommodation of several hydrophobic molecules, leading to the formation of inclusion complexes (ICs) increasing the guest molecules’ stability, allowing their controlled release, enhancing their water solubility and biodisponibility.
  • 651
  • 18 Nov 2021
Topic Review
Natural 4-Hydroxy-2-pyrones
4-Hydroxy-2-pyrones as polyketides are widespread in Nature and possess versatile bioactivity that makes them an attractive target for synthesis and modification. Also these pyrones bear several electrophilic and nucleophilic centers that determine their application in organic synthesis.
  • 394
  • 02 Jan 2024
Topic Review
Naringin
Polyphenols comprise a number of natural substances, such as flavonoids, that show interesting biological effects. Among these substances is naringin, a naturally occurring flavanone glycoside found in citrus fruits and Chinese medicinal herbs. Several studies have shown that naringin has numerous biological properties, including cardioprotective, cholesterol-lowering, anti-Alzheimer’s, nephroprotective, antiageing, antihyperglycemic, antiosteoporotic and gastroprotective, anti-inflammatory, antioxidant, antiapoptotic, anticancer and antiulcer effects. Despite its multiple benefits, the clinical application of naringin is severely restricted due to its susceptibility to oxidation, poor water solubility, and dissolution rate.
  • 1.2K
  • 24 Mar 2023
Topic Review
Naphthoquinones and Their Derivatives
In the current era, an ever-emerging threat of multidrug-resistant (MDR) pathogens pose serious health challenges to mankind. Researchers are uninterruptedly putting their efforts to design and develop alternative, innovative strategies to tackle the antibiotic resistance displayed by varied pathogens. Among several naturally derived and chemically synthesized compounds, quinones have achieved a distinct position to defeat microbial pathogens.
  • 837
  • 27 Apr 2021
Topic Review
Naphthoquinones and Parkinson’s Disease
Parkinson’s disease (PD) is a pathology of neurological origin, degenerative of the region present in the central nervous system known as substantia nigra. Naphthoquinones are the most common type of quinones and compose an important series of natural distribution metabolites of plants, animals, fungi and bacteria.
  • 308
  • 17 Nov 2023
Topic Review
Naphthoquinone and Anthraquinone
Naphthoquinone (NQ) and Anthraquinone (AQ) compounds have gained considerable interest from researchers in diverse pharmacological settings due to their biological activities, making them attractive building blocks for drug development. The literature contains many examples of NQ and AQ-based compounds, mainly derived from natural sources or synthetic, that also demonstrated promising properties against diverse AD targets. The NQ or AQ scaffolds may contribute to the biological effect against AD as main units or significant substructures. In particular, hybrid- and fragment-based drug design strategies allowed the identification of multifunctional NQ and AQ molecules, which displayed antioxidant activity and the ability to inhibit ChEs, BACE, Aβ and tau aggregation. 
  • 1.2K
  • 19 Jan 2021
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