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Topic Review
Coumarin Derivatives from Marine World
Coumarin and its derivatives have significantly attracted the attention of medicinal chemists and chemical biologists due to their huge range of biological, and in particular, pharmacological properties. Interesting families of coumarins have been found from marine sources, which has accelerated the drug discovery process by inspiring innovation or even by the identification of analogues with remarkable biological properties.
  • 1.1K
  • 13 Jan 2023
Topic Review
Synthetic Biodegradable Polymers for Antibacterial Applications
Synthetic biodegradable polymers are considered biocompatible and highly safe and have found numerous applications in the biomedical field. Due to the degradable nature of polymer implants, they can be removed at the end of the functional life of the implant without surgical intervention. In tissue engineering, synthetic biodegradable polymers usually provide suitable mechanical properties and facilitate cell proliferation and differentiation, making it an excellent material for scaffolds. Synthetic polymers have the advantage of being easy to process and mold, so there are more possibilities in terms of usage properties. Synthetic biodegradable polymers usually have no inherent antimicrobial ability. Therefore, the antimicrobial activity of synthetic polymers can be effectively improved by mixing with antimicrobial substances. 
  • 612
  • 12 Jan 2023
Topic Review
Acridine as an Anti-Tumour Agent
Acridine derivatives are a class of compounds that are being extensively researched as potential anti-cancer drugs. Acridines are well-known for their high cytotoxic activity; however, their clinical application is restricted or even excluded as a result of side effects. The photocytotoxicity of propyl acridine acts against leukaemia cell lines, with C1748 being a promising anti-tumour drug against UDP-UGT’s. CK0403 is reported in breast cancer treatment and is more potent than CK0402 against estrogen receptor-negative HER2. Acridine platinum (Pt) complexes have shown specificity on the evaluated DNA sequences; 9-anilinoacridine core, which intercalates DNA, and a methyl triazene DNA-methylating moiety were also studied. Acridine thiourea gold and acridinone derivatives act against cell lines such as MDA-MB-231, SK-BR-3, and MCF-7. Benzimidazole acridine compounds demonstrated cytotoxic activity against Dual Topo and PARP-1. 
  • 780
  • 12 Jan 2023
Topic Review
General Methods of Pyruvic Acid Production
Pyruvic acid has numerous applications in the food, chemical, and pharmaceutical industries. General methods of pyruvic acid production include chemical method and biotechnological methods
  • 1.2K
  • 12 Jan 2023
Topic Review
Prominent Pharmacological Activities of Pistacia lentiscus Polyphenols
Pistacia lentiscus (lentisk) is a plant species of the Anacardiaceae family. It is a medicinal plant that grows wild in the Mediterranean region. The plant P. lentiscus, which is used in traditional medicine, possesses pharmacological attributes and may offer significant potential as a therapeutic agent. The biological and therapeutic potentials of lentisk extracts have been evaluated in terms of antioxidant, antimicrobial, and anti-inflammatory activities. Most of these activities are related to the phenolic composition of this plant. It has been used in traditional medicine for the treatment of several diseases, such as for gastrointestinal diseases, eczema, and throat infections, due to its potent antioxidant, anti-inflammatory, and antimicrobial effects.
  • 458
  • 12 Jan 2023
Topic Review
Fungi-Mediated Synthesis of Nanoparticles
Fungi are very promising biological objects for the green synthesis of nanoparticles. Biogenic synthesis of nanoparticles using different mycological cultures and substances obtained from them is a promising, easy and environmentally friendly method. By varying the synthesis conditions, the same culture can be used to produce nanoparticles with different sizes, shapes, stability in colloids and, therefore, different biological activity. Fungi are capable of producing a wide range of biologically active compounds and have a powerful enzymatic system that allows them to form nanoparticles of various chemical elements.
  • 474
  • 12 Jan 2023
Topic Review
Intervertebral Disc Tissue Engineering with Additive Manufacturing
Intervertebral disc (IVD) degeneration is one of the major causes of lower back pain, a common health condition that greatly affects the quality of life. With an increasing elderly population and changes in lifestyle, there exists a high demand for novel treatment strategies for damaged IVDs. Researchers have investigated IVD tissue engineering (TE) as a way to restore biological and mechanical functions by regenerating or replacing damaged discs using scaffolds with suitable cells. These scaffolds can be constructed using material extrusion additive manufacturing (AM), a technique used to build three-dimensional (3D), custom discs utilising computer-aided design (CAD). Structural geometry can be controlled via the manipulation of printing parameters, material selection, temperature, and various other processing parameters
  • 446
  • 12 Jan 2023
Topic Review
Cu-Based Catalysts in Nitrogen Oxides by CO
Selective catalytic reduction of nitrogen oxides (NOx) by CO (CO-SCR) to both N2 and CO2 is a promising way to simultaneously remove two harmful gases, CO and NOx, in automobile and factory exhaust gases. The development of efficient catalysts is the key challenge for the technology to be commercialized. The low-cost Cu-based catalysts have shown promising performance in CO-SCR, but there are some technical problems that obstruct their practical implementation, such as high reduction temperature and low O2, H2O, and SO2 resistance. An overview CO-SCR under O2-containing conditions over the Cu-based catalysts is discussed.
  • 390
  • 12 Jan 2023
Topic Review
Chitosan, Zein and Essential Oil as Bio-Based Coating
Modifications of the packaging paper surface play an important role in a variety of industries, especially in the food sector. Uncoated paper has poor water and oil barrier properties due to its porous structure. Packaging paper could be successfully coated with different coating solutions containing combinations of chitosan, zein and rosemary essential oil. The chitosan and zein were actually coated in two layers; the mixed chitosan–rosemary oil and the mixed zein–rosemary oil were each applied as one layer to the paper. The results showed increased oil barrier properties in the papers coated with mixed zein–rosemary oil and reduced water permeability in the papers coated with the chitosan–rosemary oil coating solution. The result of this two-layer coating showed excellent water and oil barrier properties. All the coated papers showed a high thermal stability, especially those coated with chitosan, zein and rosemary oil layer by layer. Scanning electron microscopy was used to verify the surface di erences of the coated papers, such as the closed structure, pores and smoother surface, especially in the layer-wise coated samples. Due to their good mechanical and chemical properties, coated papers with rosemary oil can be used in many applications, possibly also in the field of repellents.
  • 493
  • 12 Jan 2023
Topic Review
Classification and Applications of 2D Xenes
Single-element-based 2D materials (Xenes) have garnered tremendous interest. At present, 16 kinds of Xenes (silicene, borophene, germanene, phosphorene, tellurene, etc.) have been explored, mainly distributed in the third, fourth, fifth, and sixth main groups. Although two Xenes (aluminene and indiene) have not been synthesized due to the limitations of synthetic methods and the stability of Xenes, other Xenes have been successfully created via elaborate artificial design and synthesis. Elemental 2D materials show potential applications in various fields, including spintronics, electronics, optoelectronics, superconducting, photovoltaics, sensors, catalysis, and biomedicines.
  • 856
  • 12 Jan 2023
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