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Topic Review
Carbazoles Treatment for COVID-19 Infection
Several treatment approaches for COVID-19 were employed since the beginning of the pandemic, such as immunomodulatory, antiviral, anti-inflammatory, antimicrobial agents, and again corticosteroids, angiotensin II receptor blockers, and bradykinin B2 receptor antagonists, but many of them were proven ineffective in targeting the virus. So, the identification of drugs to be used effectively for treatment of COVID-19 is strongly needed. Carbazoles represent an interesting class of heterocycles known by their anticancer activity: antibacterial, anti-inflammatory, antifungal, antioxidant, antimicrobial, antiepileptic, antihistamine, antiviral. In addition, numerous carbazole derivatives have also been found to be useful for Alzheimer’s disease. 
  • 688
  • 21 Feb 2023
Topic Review
P-Glycoprotein Transporter Modelling
ATP-binding cassette (ABC) transporters play a critical role in both drug bioavailability and toxicity, and with the discovery of the P-glycoprotein (P-gp), this became even more evident, as it plays an important role in preventing intracellular accumulation of toxic compounds. Intensive studies have been conducted to find new therapeutic molecules to reverse the phenomenon of multidrug resistance (MDR), that research has found is often associated with overexpression of P-gp, the most extensively studied drug efflux transporter; in MDR, therapeutic drugs are prevented from reaching their targets due to active efflux from the cell. The development of P-gp inhibitors is recognized as a good way to reverse this type of MDR, which has been the subject of extensive studies over the past few decades. Despite the progress made, no effective P-gp inhibitors to reverse multidrug resistance are yet on the market, mainly because of their toxic effects. Computational studies can accelerate this process, and in silico models such as quantitative structure-activity relationship (QSAR) models that predict the activity of compounds associated with P-gp (or analogous transporters) are of great value in the early stages of drug development, along with molecular modelling methods, which provide a way to explain how these molecules interact with the ABC transporter. 
  • 448
  • 21 Feb 2023
Topic Review
Improvement of Antibacterial Properties of Wood Surfaces
Wood is a raw material that is renewable and has good mechanical properties, as well as being inexpensive and having abundant reserves. It has been extensively employed in furniture, construction, and other industries. In addition to being a material for furniture and interior decoration, it can have applications in high-tech sectors.
  • 284
  • 21 Feb 2023
Topic Review
Nanocarriers for Active Food Packaging
Active packaging improves a packaging system’s effectiveness by actively integrating additional components into the packaging material or the headspace around the packaging. Consumer demand and awareness have grown enough to replace chemical agents with natural active agents. Essential oils (EOs) are extensively distributed throughout nature but at low levels and sometimes with poor recovery yields, which poses an issue with their application in food.
  • 318
  • 21 Feb 2023
Topic Review
Nanostructure-Modified Electrodes tor Contaminants of Environmental Concern Detection
The contaminants of environmental concern (CECs) are found in substances people all use in the  daily lives such as pharmaceuticals, pesticides, flame retardants, personal care products, and so on. These contaminants pose a threat to human and environmental well being, hence the need for effective methods for the fast and sensitive detection of these contaminants in the ecosystems. The detection of these CECs can be achieved using electrodes modified with novel nanostructures that serve to increase the sensitivity and lower the detection limits.
  • 502
  • 21 Feb 2023
Topic Review
Metal–Organic Frameworks Based on Fe and Cu
Advanced oxidation processes (AOPs) have been postulated as viable, innovative, and efficient technologies for the removal of pollutants from water. Among AOPs, photo-Fenton processes have been shown to be effective for the degradation of various types of organic compounds in industrial wastewater.
  • 381
  • 21 Feb 2023
Topic Review
Development Aspects for Practical Non-aqueous Redox-Flow Batteries
Redox-flow cells can be divided into four basic types: all-liquid redox-flow batteries (ALRFBs), semi-solid redox-flow batteries (SSRFBs), hybrid redox-flow batteries (HRFBs), and single-flow batteries (SFB). These four basic types can be further classified by their cell separation techniques and membrane setups. They range from having no separation membrane to having up to three separation membranes in parallel.
  • 761
  • 20 Feb 2023
Topic Review
Surface-Enhanced Raman Spectroscopy Nanostructure in High-Temperature Processes
Surface-enhanced Raman spectroscopy (SERS) is a highly sensitive analytical technique based on Raman scatter and utilizes the nanostructures of active metals, such as gold and silver, with roughened surfaces as a signal amplifier. With its enhancement effect and “fingerprint” ability, in situ SERS is able to capture the dynamics of microstructure evolution and trace surface species in real time, which provides direct information for the analysis of a reaction mechanism in various surface processes, including heterogeneous catalysis, electrochemical reactions, etc. SERS has been widely used in operando analysis of surface processes under ordinary temperatures. For application in high-temperature processes, the harsh environment puts forward additional requirements in addition to high sensitivity for the SERS nanostructures, especially concerning thermal stability, chemical inertness, and surface universality. 
  • 398
  • 20 Feb 2023
Topic Review
Advanced Nanostructured Materials for Electrocatalysis in Lithium–Sulfur Batteries
Lithium–sulfur (Li-S) batteries are considered as among the most promising electrochemical energy storage devices due to their high theoretical energy density and low cost. However, the inherently complex electrochemical mechanism in Li-S batteries leads to problems such as slow internal reaction kinetics and a severe shuttle effect, which seriously affect the practical application of batteries. 
  • 486
  • 20 Feb 2023
Topic Review
Steroid Oximes
Steroids and their derivatives have been the subject of extensive research among investigators due to their wide range of pharmacological properties, in which steroidal oximes are included. Oximes are a chemical group with the general formula R1R2C=N−OH and they exist as colorless crystals and are poorly soluble in water. Oximes can be easily obtained through the condensation of aldehydes or ketones with various amine derivatives, making them a very interesting chemical group in medicinal chemistry for the design of drugs as potential treatments for several diseases. A large number of steroid oximes exhibit important biological activities, such as anticancer, anti-inflammatory, antibacterial, antifungal and antiviral, among others, through different mechanisms of action. Several steroid oximes are used clinically as drugs and many others are in clinical trials.
  • 707
  • 20 Feb 2023
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