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Topic Review
Second Generation Antipsychotics
Orally administered antipsychotic drugs are the first-line treatment for psychotic disorders, such as schizophrenia and bipolar disorder. The most-used antipsychotic drugs include “atypical” or “second-generation” antipsychotics, such as quetiapine, risperidone, olanzapine, asenapine, lurasidone, zotepine, amisulpride or clozapine
  • 309
  • 01 Mar 2023
Topic Review
Organogermanium Analogues
One of the most fundamental topics in modern organogermanium chemistry is the study of low-coordinate species, and within this realm, the field of multiply bonded compounds is now one of the mainstreams. It therefore comes as no surprise that the literature covering the latter field is vast. Heteronuclear multiply bonded combinations of germanium with the Main Group elements of groups 13, 15, and 16, >Ge=E13–, >Ge=E15–, and >Ge=E16, respectively, are excluded from the consideration. Moreover, numerous compounds, in which the low-coordinate Ge center is intramolecularly (by n-donor substituents) or intermolecularly (through external donor ligands) coordinated, thus experiencing remarkable electronic perturbation, are also not considered, except for silagermenylidenes >Si=Ge(NHC): and digermanium(0) complexes :Ge0(NHC/or NHSi)=Ge0(NHC/or NHSi):, which otherwise cannot be stabilized for their isolation.
  • 401
  • 01 Mar 2023
Topic Review
Composite Formation for Dielectric Properties of Polymers
Polymer blend or composite, which is a combination of two or more polymers and fillers such as semiconductors, metals, metal oxides, salts and ceramics, are a synthesized product facilitating improved, augmented or customized properties, and have widespread applications for the achievement of functional materials. Polymer materials with embedded inorganic fillers are significantly appealing for challenging and outstanding electric, dielectric, optical and mechanical applications involving magnetic features. In particular, a polymer matrix exhibiting large values of dielectric constant (ε′) with suitable thermal stability and low dielectric constant values of polymer blend, having lesser thermal stability, together offer significant advantages in electronic packaging and other such applications in different fields.
  • 551
  • 01 Mar 2023
Topic Review
The Sensing Techniques for Formaldehyde Detection
Formaldehyde has been regarded as a common indoor pollutant and does great harm to human health, which has caused the relevant departments to pay attention to its accurate detection. Spectrophotometry, gas chromatography, liquid chromatography, and other methods have been proposed for formaldehyde detection. Among them, the gas sensor is especially suitable for common gaseous formaldehyde detection with the fastest response speed and the highest sensitivity. 
  • 472
  • 28 Feb 2023
Topic Review
Nanotechnology for Blood–Brain Barrier Crossing
Nanomedicine is currently focused on the design and development of nanocarriers that enhance drug delivery to the brain to address unmet clinical needs for treating neuropsychiatric disorders and neurological diseases. Polymer and lipid-based drug carriers are advantageous for delivery to the central nervous system (CNS) due to their safety profiles, drug-loading capacity, and controlled-release properties. Polymer and lipid-based nanoparticles (NPs) are reported to penetrate the blood–brain barrier (BBB) and have been extensively assessed in in vitro and animal models of glioblastoma, epilepsy, and neurodegenerative disease. Since approval by the Food and Drug Administration (FDA) of intranasal esketamine for treatment of major depressive disorder, intranasal administration has emerged as an attractive route to bypass the BBB for drug delivery to the CNS. NPs can be specifically designed for intranasal administration by tailoring their size and coating with mucoadhesive agents or other moieties that promote transport across the nasal mucosa.
  • 586
  • 28 Feb 2023
Topic Review
Polymers for Tissue Engineering
Tissue Engineering (TE) is an interdisciplinary field that encompasses materials science in combination with biological and engineering sciences. Polymeric porous scaffolds play a critical role in TE strategies for providing a favorable environment for tissue restoration and establishing the interaction of the biomaterial with cells and inducing substances.
  • 594
  • 28 Feb 2023
Topic Review
Synthesis of Porous Composite Metal Oxides
Porous transition-metal oxides with good intrinsic activities can be used to disperse and stabilize the active noble metal phases, thus promoting improvements in selectivity and activity of the supported noble metal catalysts and in the meanwhile reinforcing the optimized utilization of noble metals.
  • 723
  • 27 Feb 2023
Topic Review
Trabecular Tantalum
Tantalum has known ever wider applications for the production of endosseous implantable devices in the orthopedic and dental fields. Its excellent performances are due to its capacity to stimulate new bone formation, thus improving implant integration and stable fixation. Tantalum’s mechanical features can be mainly adjusted by controlling its porosity thanks to a number of versatile fabrication techniques, which allow obtaining an elastic modulus similar to that of bone tissue, thus limiting the stress-shielding effect.
  • 400
  • 27 Feb 2023
Topic Review
Drug Therapies for Alzheimer’s Disease
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by decreased synaptic transmission and cerebral atrophy with appearance of amyloid plaques and neurofibrillary tangles. Cognitive, functional, and behavioral alterations are commonly associated with the disease. Different pathophysiological pathways of AD have been proposed, some of which interact and influence one another. Treatment for AD mainly involves the use of therapeutic agents to alleviate the symptoms in AD patients. The conventional single-target treatment approaches do not often cause the desired effect in the disease due to its multifactorial origin. Thus, multi-target strategies have since been undertaken, which aim to simultaneously target multiple targets involved in the development of AD. 
  • 362
  • 27 Feb 2023
Topic Review
Bioplastics
Bioplastics are one of the possible alternative solutions to the polymers of petrochemical origins. Bioplastics have several advantages over traditional plastics in terms of low carbon footprint, energy efficiency, biodegradability and versatility.
  • 742
  • 27 Feb 2023
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