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Topic Review
Potential Treatments for Viral Diseases
The COVID-19 pandemic, as well as the more general global increase in viral diseases, has led researchers to look to the plant kingdom as a potential source for antiviral compounds. Since ancient times, herbal medicines have been extensively applied in the treatment and prevention of various infectious diseases in different traditional systems. The purpose of this review is to highlight the potential antiviral activity of plant compounds as effective and reliable agents against viral infections, especially by viruses from the coronavirus group.
  • 540
  • 26 Jul 2021
Topic Review
Magnetic Elements for Neuromorphic Computing
Neuromorphic computing is also called cognitive or adaptive computing. Brain-inspired computers could work like neuronal networks, be more energy-efficient, and could learn and solve special mathematical problems faster than recent computers. It is assumed to be significantly more energy efficient than, and at the same time expected to outperform, conventional computers in several applications, such as data classification, since it overcomes the so-called von Neumann bottleneck. Artificial synapses and neurons can be implemented into conventional hardware using new software, but also be created by diverse spintronic devices and other elements to completely avoid the disadvantages of recent hardware architecture.
  • 540
  • 01 Dec 2021
Topic Review
Mechanisms of Temperature-Responsive Polymer Brush Coatings
Modern biomedical technologies predict the application of materials and devices that not only can comply effectively with specific requirements, but also enable remote control of their functions. One of the most prospective materials for these advanced biomedical applications are materials based on temperature-responsive polymer brush coatings (TRPBCs). Despite progress in the development of such interesting materials, there are still some issues that need to be resolved, such as biocompatibility, high efficiency, selectivity of the action, stability, long-term and multiple-use, and the temperature of the transition close to physiological temperatures (appropriate transition temperature). The mechanisms of their temperature-induced reactions are one of the most crucial elements that affect the characteristics of temperature-sensitive grafted brush coatings. The TRPBCs exhibit the response to temperature governed by different mechanisms attributed to intermolecular interactions of the macromolecular chains between themselves and with the environment. The mechanism responsible for the temperature-dependent properties of polymer brushes is strongly dependent on the chemical nature of the macromolecular chains.
  • 540
  • 20 Oct 2022
Topic Review
GO/TiO2-Related Nanocomposites as Photocatalysts in Wastewater Treatment
Photocatalysis is a more recently applied concept and is proven to be able to completely remove and degrade pollutants into simpler organic compounds. Titanium dioxide (TiO2) is a fine example of a photocatalyst owing to its cost-effectiveness and superb efficiency. However, issues such as the high recombination rate of photogenerated electrons along with positive holes while being only limited to UV irradiation need to be addressed. Carbonaceous materials such as graphene oxide (GO) can overcome such issues by reducing the recombination rate and providing a platform for adsorption accompanied by photocatalytic degradation of TiO2.
  • 540
  • 28 Nov 2022
Topic Review
Latex Allergy
Latex allergy is a medical term encompassing a range of allergic reactions to the proteins present in natural rubber latex. It generally develops after repeated exposure to products containing natural rubber latex. When latex-containing medical devices or supplies come in contact with mucous membranes, the membranes may absorb latex proteins. In some susceptible people, the immune system produces antibodies that react immunologically with these antigenic proteins. Many items contain or are made from natural rubber, including shoe soles, pen grips, hot water bottles, elastic bands, rubber gloves, condoms, baby-bottle nipples, and balloons; consequently, there are many possible routes of exposure that may trigger a reaction. People with latex allergies may also have or develop allergic reactions to some fruits, such as bananas.
  • 540
  • 28 Apr 2023
Topic Review
Boron Vehiculating Nanosystems in Cancer Treatment
Boron neutron capture therapy is a low-invasive cancer therapy based on the neutron fission process that occurs upon thermal neutron irradiation of 10B-containing compounds; this process causes the release of alpha particles that selectively damage cancer cells. Although several clinical studies involving mercaptoundecahydro-closo-dodecaborate and the boronophenylalanine–fructose complex are currently ongoing, the success of this promising anticancer therapy is hampered by the lack of appropriate drug delivery systems to selectively carry therapeutic concentrations of boron atoms to cancer tissues, allowing prolonged boron retention therein and avoiding the damage of healthy tissues. To achieve these goals, numerous research groups have explored the possibility to formulate nanoparticulate systems for boron delivery. Here the researchers report the newest developments on boron vehiculating drug delivery systems based on nanoparticles, distinguished on the basis of the type of carrier used, with a specific focus on the formulation aspects.
  • 540
  • 21 Dec 2022
Topic Review
Cyanomethylation Reaction
Cyanomethylation is very useful in organic synthesis because the cyano groups can be hydrolyzed to carboxylic acids and reduced to amines, from which other functional groups can be derived. In addition, the cyano group is the structural unit of many drugs, such as piritramide, diphenozlate, and gallopamil, while acetonitrile is an ideal source of the cyanomethyl functional group due to the difficulty in breaking the C-CN bond. 
  • 540
  • 08 May 2023
Topic Review
MOS Gas Sensor for Lung Cancer Diagnosis
Lung cancer is the most prevalent severe illness in both sexes and all ages and the leading cause of cancer-related deaths globally. Late-stage diagnosis is the primary cause of its high mortality rate. Therefore, the management of lung cancer needs early-stage screening. Breath analysis is a non-invasive, low-cost, and user-friendly approach to diagnosing lung cancer. Among the various types of breath sensors, metal oxide semiconductor (MOS) gas sensors are preferred due to their high gas responses, fast response times, robustness, and lower price.
  • 540
  • 06 May 2023
Topic Review
Bisphosphonate-Based Conjugates and Derivatives
Metastatic bone cancer occurs in every type of cancer but is prevalent in lung, breast, and prostate cancers. These metastases can cause extensive morbidity, including a range of skeletal-related events, often painful and linked with substantial hospital resource usage. The treatment used is a combination of chemotherapy and surgery. However, anticancer drugs are still limited because of severe side effects, drug resistance, poor blood supply, and non-specific drug uptake, necessitating high toxic doses. Bisphosphonates are the dominant class of drugs used to inhibit metastatic bone cancer. It is also used to treat osteoporosis and other bone diseases. However, bisphosphonate also suffers from serious side effects. Thus, there is a serious need to develop bisphosphonate conjugates with promising therapeutic outcomes for treating metastatic bone cancer and osteoporosis. This review article focuses on the biological outcomes of designed bisphosphonate-based conjugates for the treatment of metastatic bone cancer and osteoporosis. 
  • 539
  • 09 Jul 2021
Topic Review
Natural Polymer-Based Hydrogels for Glaucoma Therapy
Biopolymers have been extensively investigated in a number of medical fields, including tissue engineering and drug delivery. This is largely due to the fact that they are biodegradable within the body, and do not induce an inflammatory reaction. Polynucleotides such as nucleic acids (DNA and RNA), proteins such as polypeptides, and polyesters derived from both plants and animals are also used. When compared to synthetic polymers, naturally occurring biopolymers and their derivatives have acquired preference, and have a comprehensive range of applications in pharmaceutical as well as biomedical research. Natural biopolymers are preferred for medical applications due to their biodegradability, biostability, biocompatibility, and non-toxicity. Additionally, natural polymers have the advantage of being readily available, economically friendly, and ecofriendly. Hydrogels designed from natural polymers exhibit high potential as drug delivery systems for biomaterials to treat ocular impairments.
  • 539
  • 28 Jun 2022
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